Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Marc Bockx"'
Autor:
Ellen Scheers, Juthamas Sukbuntherng, Nini Bode, Joseph Murphy, Jan de Jong, Donna Skee, Geert Mannens, Filip Cuyckens, Marc Bockx, Aline Laenen, Laurent Leclercq
Publikováno v:
Drug Metabolism and Disposition. 43:289-297
The absorption, metabolism, and excretion of ibrutinib were investigated in healthy men after administration of a single oral dose of 140 mg of ¹⁴C-labeled ibrutinib. The mean (S.D.) cumulative excretion of radioactivity of the dose was 7.8% (1.4%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ea02f160f6da77e3d84d958cd71c33a
https://doi.org/10.1124/dmd.114.060061
https://doi.org/10.1124/dmd.114.060061
Publikováno v:
Journal of Chromatography A. 1372:102-109
An online preconcentration approach was developed allowing the injection of very high volumes of biological samples, thereby greatly increasing sensitivity while maintaining LC resolution. The approach was applied to the analysis of radioactive sampl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59a1a1e5c2a5c0dada0555ef12c5112
https://doi.org/10.1016/j.chroma.2014.10.087
https://doi.org/10.1016/j.chroma.2014.10.087
Publikováno v:
Metabolite Safety in Drug Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16330e8bbd51d117463c7169d0670781
https://doi.org/10.1002/9781118949689.ch13
https://doi.org/10.1002/9781118949689.ch13
Autor:
Ronald de Vries, Lieve Dillen, Russell J. Mortishire-Smith, Liesbeth Vereyken, W. Cools, Filip Cuyckens, Marc Bockx
Publikováno v:
Bioanalysis. 4:595-604
Background: Peptides represent a growing class of potential drugs. Information on metabolic clearance can be valuable for peptide drug development but different challenges are encountered with the identification of peptide metabolites in comparison t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8725245c13826db1f9998952d9bfe0bf
https://doi.org/10.4155/bio.11.333
https://doi.org/10.4155/bio.11.333
Publikováno v:
Analytical and Bioanalytical Chemistry. 402:439-448
The aim of this work was speciation analysis of metabolites in feces samples collected within a clinical study during which a bromine-containing anti-tuberculosis drug (TMC207) was administered to patients with multi-drug resistant tuberculosis infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9988f903a5c11e3be3bdf275bb8dd3a2
https://doi.org/10.1007/s00216-011-5339-y
https://doi.org/10.1007/s00216-011-5339-y
Autor:
Filip Cuyckens, Geert Mannens, Andrés Francesch, Kathleen Steemans, Pablo Aviles, Jos M. Van Houdt, Alex Hemeryck, Roland De Coster, Marc Bockx, Marc Vermeir
Publikováno v:
Biochemical Pharmacology. 77:1642-1654
Trabectedin (YONDELIS ® ) is a potent anticancer agent which was recently approved in Europe for the treatment of soft tissue sarcoma. The drug is currently also in clinical development for the treatment of ovarian carcinoma. In vitro experiments we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac38beac9c9f173290be9c67dc6da9bd
https://doi.org/10.1016/j.bcp.2009.02.020
https://doi.org/10.1016/j.bcp.2009.02.020
Autor:
Ellen, Scheers, Laurent, Leclercq, Jan, de Jong, Nini, Bode, Marc, Bockx, Aline, Laenen, Filip, Cuyckens, Donna, Skee, Joe, Murphy, Juthamas, Sukbuntherng, Geert, Mannens
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 43(2)
The absorption, metabolism, and excretion of ibrutinib were investigated in healthy men after administration of a single oral dose of 140 mg of ¹⁴C-labeled ibrutinib. The mean (S.D.) cumulative excretion of radioactivity of the dose was 7.8% (1.4%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aad7c53b5e2b4abc196f57d90d83c0a2
https://pubmed.ncbi.nlm.nih.gov/25488930
https://pubmed.ncbi.nlm.nih.gov/25488930
Autor:
C. Borgmans, Marc Bockx, Willem Meuldermans, C. Zwijsen, Geert Mannens, J. Hendrickx, J. Heykants
Publikováno v:
Journal of Chromatography A. 729:341-354
Nebivolol hydrochloride (R067555), is a new antihypertensive drug. Aromatic and alicyclic hydroxylation at the benzopyran ring systems of nebivolol are important metabolic pathways. Generally, NMR is used to unambiguously assign the sites of hydroxyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5abe84263f01cf7e70e6becc7e1d39c
https://doi.org/10.1016/0021-9673(95)01114-5
https://doi.org/10.1016/0021-9673(95)01114-5
Autor:
Willem Meuldermans, Geert Mannens, B. Verreet, Marc Bockx, M. Bialer, B. Van Hoof, Tom Verhaeghe, Mark L. Kao, Michael F. Kelley, S. Chien, J. Hendrickx, Cor G. M. Janssen, I. Goris
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 35(4)
RWJ-333369 (1,2-ethanediol, [1-2-chlorophenyl]-, 2-carbamate, [S]-; CAS Registry Number 194085-75-1) is a novel neuromodulator in clinical development for the treatment of epilepsy. To study the disposition of RWJ-333369, eight healthy male subjects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72358f714432fbafa7650b88b20a8f03
https://pubmed.ncbi.nlm.nih.gov/16936066
https://pubmed.ncbi.nlm.nih.gov/16936066