Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Marc Biran"'
Autor:
Gergana Taleva, Michaela Husová, Brian Panicucci, Carolina Hierro-Yap, Erika Pineda, Marc Biran, Martin Moos, Petr Šimek, Falk Butter, Frédéric Bringaud, Alena Zíková
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011699 (2023)
The long slender bloodstream form Trypanosoma brucei maintains its essential mitochondrial membrane potential (ΔΨm) through the proton-pumping activity of the FoF1-ATP synthase operating in the reverse mode. The ATP that drives this hydrolytic reac
Externí odkaz:
https://doaj.org/article/4dc3c4c623334b23bad5e9817194ed8a
Autor:
Stefan Allmann, Marion Wargnies, Nicolas Plazolles, Edern Cahoreau, Marc Biran, Pauline Morand, Erika Pineda, Hanna Kulyk, Corinne Asencio, Oriana Villafraz, Loïc Rivière, Emmanuel Tetaud, Brice Rotureau, Arnaud Mourier, Jean-Charles Portais, Frédéric Bringaud
Publikováno v:
PLoS Biology, Vol 19, Iss 8, p e3001359 (2021)
Microorganisms must make the right choice for nutrient consumption to adapt to their changing environment. As a consequence, bacteria and yeasts have developed regulatory mechanisms involving nutrient sensing and signaling, known as "catabolite repre
Externí odkaz:
https://doaj.org/article/9f4cf4efa05d45079da2a16ebf1a090b
Autor:
Rodolpho Ornitz Oliveira Souza, Flávia Silva Damasceno, Sabrina Marsiccobetre, Marc Biran, Gilson Murata, Rui Curi, Frédéric Bringaud, Ariel Mariano Silber
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009495 (2021)
Trypanosoma cruzi, the parasite causing Chagas disease, is a digenetic flagellated protist that infects mammals (including humans) and reduviid insect vectors. Therefore, T. cruzi must colonize different niches in order to complete its life cycle in
Externí odkaz:
https://doaj.org/article/cd55392578814552820dabed62e9d822
Autor:
Oriana Villafraz, Marc Biran, Erika Pineda, Nicolas Plazolles, Edern Cahoreau, Rodolpho Ornitz Oliveira Souza, Magali Thonnus, Stefan Allmann, Emmanuel Tetaud, Loïc Rivière, Ariel M Silber, Michael P Barrett, Alena Zíková, Michael Boshart, Jean-Charles Portais, Frédéric Bringaud
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009204 (2021)
Trypanosoma brucei, a protist responsible for human African trypanosomiasis (sleeping sickness), is transmitted by the tsetse fly where the procyclic forms of the parasite develop in the proline-rich (1-2 mM) and glucose-depleted digestive tract. Pro
Externí odkaz:
https://doaj.org/article/1885a736cc92490ba8841d001d3da10c
Autor:
Marion Wargnies, Eloïse Bertiaux, Edern Cahoreau, Nicole Ziebart, Aline Crouzols, Pauline Morand, Marc Biran, Stefan Allmann, Jane Hubert, Oriana Villafraz, Yoann Millerioux, Nicolas Plazolles, Corinne Asencio, Loïc Rivière, Brice Rotureau, Michael Boshart, Jean-Charles Portais, Frédéric Bringaud
Publikováno v:
PLoS Pathogens, Vol 14, Iss 12, p e1007502 (2018)
In the glucose-free environment that is the midgut of the tsetse fly vector, the procyclic form of Trypanosoma brucei primarily uses proline to feed its central carbon and energy metabolism. In these conditions, the parasite needs to produce glucose
Externí odkaz:
https://doaj.org/article/60552535c32246a7a65a3248f93a9af3
Autor:
Erika Pineda, Magali Thonnus, Muriel Mazet, Arnaud Mourier, Edern Cahoreau, Hanna Kulyk, Jean-William Dupuy, Marc Biran, Cyril Masante, Stefan Allmann, Loïc Rivière, Brice Rotureau, Jean-Charles Portais, Frédéric Bringaud
Publikováno v:
PLoS Pathogens, Vol 14, Iss 11, p e1007412 (2018)
The bloodstream forms of Trypanosoma brucei (BSF), the parasite protist causing sleeping sickness, primarily proliferate in the blood of their mammalian hosts. The skin and adipose tissues were recently identified as additional major sites for parasi
Externí odkaz:
https://doaj.org/article/62070a37071f4a23bf79a14ce1ae0583
Autor:
Yoann Millerioux, Muriel Mazet, Guillaume Bouyssou, Stefan Allmann, Tiila-Riikka Kiema, Eloïse Bertiaux, Laetitia Fouillen, Chandan Thapa, Marc Biran, Nicolas Plazolles, Franziska Dittrich-Domergue, Aline Crouzols, Rik K Wierenga, Brice Rotureau, Patrick Moreau, Frédéric Bringaud
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1007116 (2018)
De novo biosynthesis of lipids is essential for Trypanosoma brucei, a protist responsible for the sleeping sickness. Here, we demonstrate that the ketogenic carbon sources, threonine, acetate and glucose, are precursors for both fatty acid and sterol
Externí odkaz:
https://doaj.org/article/9b8c7166f68b4ddd91c300754abc93b5
Autor:
Brian S Mantilla, Letícia Marchese, Aitor Casas-Sánchez, Naomi A Dyer, Nicholas Ejeh, Marc Biran, Frédéric Bringaud, Michael J Lehane, Alvaro Acosta-Serrano, Ariel M Silber
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006158 (2017)
Adaptation to different nutritional environments is essential for life cycle completion by all Trypanosoma brucei sub-species. In the tsetse fly vector, L-proline is among the most abundant amino acids and is mainly used by the fly for lactation and
Externí odkaz:
https://doaj.org/article/b3c6cd45955e4fbeb69fe74e831ff464
Autor:
Darren J Creek, Muriel Mazet, Fiona Achcar, Jana Anderson, Dong-Hyun Kim, Ruwida Kamour, Pauline Morand, Yoann Millerioux, Marc Biran, Eduard J Kerkhoven, Achuthanunni Chokkathukalam, Stefan K Weidt, Karl E V Burgess, Rainer Breitling, David G Watson, Frédéric Bringaud, Michael P Barrett
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004689 (2015)
Metabolomics coupled with heavy-atom isotope-labelled glucose has been used to probe the metabolic pathways active in cultured bloodstream form trypomastigotes of Trypanosoma brucei, a parasite responsible for human African trypanosomiasis. Glucose e
Externí odkaz:
https://doaj.org/article/6f5a415b91f34ce6b29b7e4fca138d7b
Autor:
Muriel Mazet, Pauline Morand, Marc Biran, Guillaume Bouyssou, Pierrette Courtois, Sylvie Daulouède, Yoann Millerioux, Jean-Michel Franconi, Philippe Vincendeau, Patrick Moreau, Frédéric Bringaud
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 12, p e2587 (2013)
BACKGROUND: The bloodstream forms of Trypanosoma brucei, the causative agent of sleeping sickness, rely solely on glycolysis for ATP production. It is generally accepted that pyruvate is the major end-product excreted from glucose metabolism by the p
Externí odkaz:
https://doaj.org/article/d64332a40ccc4dbeb5a11d3150ce32eb