Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Marc BENHAMOU"'
Autor:
John TCHEN, Quentin SIMON, Léa CHAPART, Morgane K. THAMINY, Shamila VIBHUSHAN, Loredana SAVEANU, Yasmine LAMRI, Fanny SAIDOUNE, Emeline PACREAU, Christophe PELLEFIGUES, Julie BEX-COUDRAT, Hajime KARASUYAMA, Kensuke MIYAKE, Juan HIDALGO, Padraic G. FALLON, Thomas PAPO, Ulrich BLANK, Marc BENHAMOU, Guillaume HANOUNA, Karim SACRE, Eric DAUGAS, Nicolas CHARLES
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by anti-nuclear autoantibodies whose production is promoted by autoreactive T follicular helper (TFH) cells. During SLE pathogenesis, basophils accumulate in secondary
Externí odkaz:
https://doaj.org/article/2b261c12033c4401a2b53ad4f143bfa7
Autor:
Manuela Bratti, Shamila Vibhushan, Cyril Longé, Despoina Koumantou, Gaël Ménasché, Marc Benhamou, Nadine Varin-Blank, Ulrich Blank, Loredana Saveanu, Sanae Ben Mkaddem
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The function of intracellular trafficking in immune-complex triggered inflammation remains poorly understood. Here, we investigated the role of Insulin-Regulated Amino Peptidase (IRAP)-positive endosomal compartments in Fc receptor (FcR)-induced infl
Externí odkaz:
https://doaj.org/article/3faaf41d039145589aa4626bfa0fc628
Autor:
John Tchen, Quentin Simon, Léa Chapart, Christophe Pellefigues, Hajime Karasuyama, Kensuke Miyake, Ulrich Blank, Marc Benhamou, Eric Daugas, Nicolas Charles
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Tissue-specific mouse models are essential tools to decipher the role of each cell compartment and/or their expressed genes in the pathophysiology of diseases. Here, we describe a new knock-in mouse model allowing expression of both the fluorescent p
Externí odkaz:
https://doaj.org/article/6d84a6fd725646d891b31d23a059b29f
Autor:
Camille Cohen, Séverine Coulon, Kanit Bhukhai, Antoine Neuraz, Michael Dussiot, Guillemette Fouquet, Marie-Bénédicte Le Stang, Martin Flamant, François Vrtovsnik, Aurélie Hummel, Bertrand Knebelmann, Laurent Mesnard, Eric Rondeau, Thiago T. Maciel, Fabrizia Favale, Nicole Casadevall, Thao Nguyen-Khoa, Stéphane Moutereau, Christophe Legendre, Marc Benhamou, Renato C. Monteiro, Olivier Hermine, Khalil El Karoui, Ivan C. Moura
Publikováno v:
EBioMedicine, Vol 75, Iss , Pp 103785- (2022)
Summary: Background: Erythrocytosis is a hematological disorder usually related to hematopoietic stem cell somatic mutations. However, unexplained erythrocytosis remains frequent. In this study, we evaluated the involvement of IgA1, a regulator of er
Externí odkaz:
https://doaj.org/article/736d119de1ba4bb9b49d07811c31cf55
Autor:
Etienne Paubelle, Florence Zylbersztejn, Thiago Trovati Maciel, Caroline Carvalho, Annalisa Mupo, Meyling Cheok, Liesbet Lieben, Pierre Sujobert, Justine Decroocq, Akihiko Yokoyama, Vahid Asnafi, Elizabeth Macintyre, Jérôme Tamburini, Valérie Bardet, Sylvie Castaigne, Claude Preudhomme, Hervé Dombret, Geert Carmeliet, Didier Bouscary, Yelena Z. Ginzburg, Hughes de Thé, Marc Benhamou, Renato C. Monteiro, George S. Vassiliou, Olivier Hermine, Ivan C. Moura
Publikováno v:
Cell Reports, Vol 30, Iss 3, Pp 739-754.e4 (2020)
Summary: Vitamin D (VD) is a known differentiating agent, but the role of VD receptor (VDR) is still incompletely described in acute myeloid leukemia (AML), whose treatment is based mostly on antimitotic chemotherapy. Here, we present an unexpected r
Externí odkaz:
https://doaj.org/article/53df66dd75014af1bb8489c5bd9cd832
Autor:
Sanae Ben Mkaddem, Amaya Murua, Héloise Flament, Dimitri Titeca-Beauport, Carine Bounaix, Luca Danelli, Pierre Launay, Marc Benhamou, Ulrich Blank, Eric Daugas, Nicolas Charles, Renato C. Monteiro
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Src-family kinases Fyn and Lyn are signaling components downstream of ITAM-bearing antigen receptors. Here the authors show that by phosphorylating SHP-1 at different residues, Lyn and Fyn can have opposing regulatory effects on ITAM receptors.
Externí odkaz:
https://doaj.org/article/018c8dd96b534ef981f995c3443a4374
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Fc receptors (FcRs) belong to the ITAM-associated receptor family. FcRs control the humoral and innate immunity which are essential for appropriate responses to infections and prevention of chronic inflammation or auto-immune diseases. Following thei
Externí odkaz:
https://doaj.org/article/85f30c7dd76b4fbba7c40f345dab70bf
Autor:
Christian de Tymowski, Nicholas Heming, Mario D.T. Correia, Lilia Abbad, Nathalie Chavarot, Marie-Bénédicte Le Stang, Heloise Flament, Julie Bex, Erwan Boedec, Carine Bounaix, Rafael Soler-Torronteras, Erick Denamur, Lionel Galicier, Eric Oksenhendler, Hans Joerg Fehling, Fabiano Pinheiro da Silva, Marc Benhamou, Renato C. Monteiro, Sanae Ben Mkaddem
Publikováno v:
Cell Reports, Vol 27, Iss 3, Pp 762-775.e5 (2019)
Summary: Direct bacterial recognition by innate receptors is crucial for bacterial clearance. Here, we show that the IgA receptor CD89 is a major innate receptor that directly binds bacteria independently of its cognate ligands IgA and c-reactive pro
Externí odkaz:
https://doaj.org/article/bf089cfc5d0a43ffab945593bfe779d3
Autor:
Flavie Ngo Nyekel, Emeline Pacreau, Samira Benadda, Rasha Msallam, Magnus Åbrink, Gunnar Pejler, Jean Davoust, Marc Benhamou, Nicolas Charles, Pierre Launay, Ulrich Blank, Gregory Gautier
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Recent evidences indicate an important role of tissue inflammatory responses by innate immune cells in allograft acceptance and survival. Here we investigated the role of mast cells (MC) in an acute male to female skin allograft rejection model using
Externí odkaz:
https://doaj.org/article/19eba69396d14f69908173f038c7f8cf
Autor:
Asma Kassas-Guediri, Julie Coudrat, Emeline Pacreau, Pierre Launay, Renato C Monteiro, Ulrich Blank, Nicolas Charles, Marc Benhamou
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173815 (2017)
Mast cells are critical actors of hypersensitivity type I (allergic) reactions by the release of vasoactive and proinflammatory mediators following their activation by aggregation of the high-affinity receptor for immunoglobulin E (FcεRI). We have p
Externí odkaz:
https://doaj.org/article/31ea533ec4b947b98ac4065826e33043