Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Marc Bühler"'
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Since the introduction of next generation sequencing technologies, the field of epigenomics has evolved rapidly. However, most commonly used assays are enrichment-based methods and thus only semi-quantitative. Nucleosome occupancy and methyl
Externí odkaz:
https://doaj.org/article/d24fbde6bfc84185b1006c146eb010a9
Autor:
Claudio Peter D’Incal, Elisa Cappuyns, Kaoutar Choukri, Kevin De Man, Kristy Szrama, Anthony Konings, Lina Bastini, Kim Van Meel, Amber Buys, Michele Gabriele, Ludovico Rizzuti, Alessandro Vitriolo, Giuseppe Testa, Fabio Mohn, Marc Bühler, Nathalie Van der Aa, Anke Van Dijck, R. Frank Kooy, Wim Vanden Berghe
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-23 (2024)
Abstract Heterozygous de novo mutations in the Activity-Dependent Neuroprotective Homeobox (ADNP) gene underlie Helsmoortel-Van der Aa syndrome (HVDAS). Most of these mutations are situated in the last exon and we previously demonstrated escape from
Externí odkaz:
https://doaj.org/article/f7c381ec5b634584bcd2d05f0e32ea1f
Autor:
Yukiko Shimada, Sarah H Carl, Merle Skribbe, Valentin Flury, Tahsin Kuzdere, Georg Kempf, Marc Bühler
Publikováno v:
PLoS Genetics, Vol 17, Iss 6, p e1009645 (2021)
Small non-protein coding RNAs are involved in pathways that control the genome at the level of chromatin. In Schizosaccharomyces pombe, small interfering RNAs (siRNAs) are required for the faithful propagation of heterochromatin that is found at peri
Externí odkaz:
https://doaj.org/article/03485bdb21044e4d8602dc98b3a87820
Publikováno v:
Biology Open, Vol 9, Iss 6 (2020)
Adenine auxotrophy is a commonly used non-selective genetic marker in yeast research. It allows investigators to easily visualize and quantify various genetic and epigenetic events by simply reading out colony color. However, manual counting of large
Externí odkaz:
https://doaj.org/article/4e994aace50441edb397c58bb3c414ed
Autor:
Matyas Flemr, Marc Bühler
Publikováno v:
Cell Reports, Vol 12, Iss 4, Pp 709-716 (2015)
Induction of double-strand DNA breaks (DSBs) by engineered nucleases, such as CRISPR/Cas9 or transcription activator-like effector nucleases (TALENs), stimulates knockin of exogenous DNA fragments via homologous recombination (HR). However, the knock
Externí odkaz:
https://doaj.org/article/2de1e6b051464f57ad31bfd682964841
Autor:
Daniele Oberti, Adriano Biasini, Moritz Alexander Kirschmann, Christel Genoud, Rieka Stunnenberg, Yukiko Shimada, Marc Bühler
Publikováno v:
Cell Reports, Vol 10, Iss 1, Pp 47-61 (2015)
Epigenetic mechanisms can be influenced by environmental cues and thus evoke phenotypic variation. This plasticity can be advantageous for adaptation but also detrimental if not tightly controlled. Although having attracted considerable interest, it
Externí odkaz:
https://doaj.org/article/5e4a3b266e2d4674a4937b488daa3fdd
Autor:
Tahsin, Kuzdere, Valentin, Flury, Thomas, Schalch, Vytautas, Iesmantavicius, Daniel, Hess, Marc, Bühler
Publikováno v:
EMBO reportsReferences. 24(1)
Methylation of histone H3 at lysine 9 (H3K9) is a hallmark of heterochromatin that plays crucial roles in gene silencing, genome stability, and chromosome segregation. In Schizosaccharomyces pombe, Clr4 mediates both di- and tri-methylation of H3K9.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3ae7bfc80ed9dcd58bec8bd6909e49e1
https://pubmed.ncbi.nlm.nih.gov/36408846
https://pubmed.ncbi.nlm.nih.gov/36408846
Publikováno v:
Cell Reports. 42:112569
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ff5ee169f34c8c640751b11fc858425
https://doi.org/10.1016/j.celrep.2023.112569
https://doi.org/10.1016/j.celrep.2023.112569
Autor:
Megumi Onishi-Seebacher, Galina Erikson, Katharina Fritz, Thomas Jenuwein, Philip Knuckles, Valentina Perrera, Mark Helm, Reagan W. Ching, Katarzyna J Duda, Marc Bühler, Gerhard Mittler, Bettina Engist, Florian Richter, Nicholas Shukeir, Lisa Jerabek
Publikováno v:
Nucleic Acids Research (London)
Nucleic Acids Research
Nucleic Acids Research
Heterochromatin has essential functions in maintaining chromosome structure, in protecting genome integrity and in stabilizing gene expression programs. Heterochromatin is often nucleated by underlying DNA repeat sequences, such as major satellite re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f42e7cd6ed63188ff81bb2e05227df
https://doi.org/10.1093/nar/gkab364
https://doi.org/10.1093/nar/gkab364
