Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Marc B, Skaddan"'
Autor:
Lindsey R. Drake, Allen F. Brooks, Jenelle Stauff, Phillip S. Sherman, Janna Arteaga, Robert A. Koeppe, Aimee Reed, Timothy J. Montavon, Marc B. Skaddan, Peter J.H. Scott
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 10, Iss 5, Pp 452-465 (2020)
The implication of the receptor for advanced glycation end-products (RAGE) in numerous diseases and neurodegenerative disorders makes it interesting both as a therapeutic target and as an inflammatory biomarker. In the context of investigating RAGE a
Externí odkaz:
https://doaj.org/article/7cc4d8c7511c42c49f3782ccdbc29d6c
Autor:
Marc B. Skaddan, Dustin W. Wooten, Kyle C. Wilcox, Martin J. Voorbach, David R. Reuter, Zhaozhong J. Jia, Kelly D. Foster-Duke, Jonathan A. Hickson, Srirajan Vaidyanathan, Aimee D. Reed, Ann E. Tovcimak, Qi Guo, Robert A. Comley, Lance Lee, Sjoerd J. Finnema, Sarah R. Mudd
Publikováno v:
Molecular Imaging and Biology. 24:830-841
Autor:
Paul Tempest, Chin‐Yin Tai, Maiko Ono, Marc B Skaddan, Kyle C Wilcox, Aimee Reed, Srirajan Vaidyanathan, Claus T Christoffersen, Pekka Kallunki, Benny Bang‐Andersen, Richard A Margolin, Tzu‐Huei Kao, Makoto Higuchi, Ming‐Kuei Jang
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Thomas Erhard, Melanie S. Sanford, Christian Bruetting, Sean S. Tanzey, Bradford D. Henderson, Andrew V. Mossine, Jason Miller, Naoko Ichiishi, Peter J. H. Scott, Allen F. Brooks, Marc B. Skaddan, Katarina J. Makaravage
Publikováno v:
Nature Protocols. 15:1742-1759
[18F]6-fluoro-L-DOPA ([18F]FDOPA) is a diagnostic radiopharmaceutical for positron emission tomography (PET) imaging that is used to image Parkinson's disease, brain tumors, and focal hyperinsulinism of infancy. Despite these important applications,
Autor:
Nandini Chaturbhai Patel, Richard V. Coelho, Christopher John Helal, Chewah Lee, Anabella Villalobos, Shawn D. Doran, Joseph Michael Young, Robert J. Mather, Simone Sciabola, Erik Alphie Lachapelle, John T. Lazzaro, Thomas Allen Chappie, Patrick Robert Verhoest, Zoë A. Hughes, Marc B. Skaddan, Elizabeth Mary Beck, John M. Humphrey, Kyle Kuszpit, Laigao Chen, Lei Zhang, Kenneth R. Zasadny, Kuo-Hsien Fan
Publikováno v:
Journal of Medicinal Chemistry. 60:8538-8551
As part of our effort in identifying phosphodiesterase (PDE) 4B-preferring inhibitors for the treatment of central nervous system (CNS) disorders, we sought to identify a positron emission tomography (PET) ligand to enable target occupancy measuremen
Autor:
Daniel P. Walker, Antonia F. Stepan, Mark A. Moen, Gregg D. Cappon, Christopher Houle, Annie C Won, Joshua R. Dunetz, Michael John Bohanon, Lei Zhang, Marc B. Skaddan, Patrick Robert Verhoest, Susan E. Drozda, Xinjun Hou, Kenneth R. Zasadny, Julie Cianfrogna, Deborah L. Smith, Ann S. Wright, John T. Lazzaro, Steven Victor O'neil, Patrick Trapa, Emily Miller, Somraj Ghosh, Gabriela Barreiro, John M. Marcek, Margaret M. Zaleska, Jason Barricklow, Michelle Marie Claffey, Lois K. Chenard, Jessica Mancuso, Christopher L. Shaffer, Jessica Whritenour, Gayatri Balan, Brian P. Boscoe, Vinod D. Parikh, Karen J. Coffman, Laigao Chen, Isao Sakurada, Jamison B. Tuttle, Matthew R. Reese, Karki Kapil Kumar
Publikováno v:
Journal of Medicinal Chemistry. 60:7764-7780
We previously observed a cutaneous type IV immune response in nonhuman primates (NHP) with the mGlu5 negative allosteric modulator (NAM) 7. To determine if this adverse event was chemotype- or mechanism-based, we evaluated a distinct series of mGlu5
Autor:
Andrew V, Mossine, Sean S, Tanzey, Allen F, Brooks, Katarina J, Makaravage, Naoko, Ichiishi, Jason M, Miller, Bradford D, Henderson, Marc B, Skaddan, Melanie S, Sanford, Peter J H, Scott
Publikováno v:
Org Biomol Chem
A one-pot two-step synthesis of 6-[(18)F]fluoro-L-DOPA ([(18)F]FDOPA) has been developed involving Cu-mediated radiofluorination of a pinacol boronate ester precursor. The method is fully automated, provides [(18)F]FDOPA in good activity yield (104
Autor:
Andrew V, Mossine, Sean S, Tanzey, Allen F, Brooks, Katarina J, Makaravage, Naoko, Ichiishi, Jason M, Miller, Bradford D, Henderson, Thomas, Erhard, Christian, Bruetting, Marc B, Skaddan, Melanie S, Sanford, Peter J H, Scott
Publikováno v:
Nat Protoc
[(18)F]6-Fluoro-L-DOPA ([(18)F]FDOPA), is used for diagnostic PET imaging. Using this protocol, radiofluorination of the electron-rich catechol ring can be achieved in the presence of the amino acid group by Cu-mediated fluorination of a pinacol boro
Autor:
Nabeel Nabulsi, Soheila Najafzadeh, Tracey Boyden, Christopher John Helal, Cheng Chang, Jim Ropchan, Shu Fei Lin, Marc B. Skaddan, Anabella Villalobos, Lei Zhang, Yiyun Huang, Kenneth R. Zasadny, Laigao Chen, Richard E. Carson, Mika Naganawa
Publikováno v:
Journal of Nuclear Medicine. 57:1448-1453
The enzyme phosphodiesterase 2A (PF-05270430) is a potential target for development of novel therapeutic agents for the treatment of cognitive impairments. The goal of the present study was to evaluate the PDE2A ligand 18F-PF-05270430, 4-(3-fluoroaze
Autor:
Patrick Robert Verhoest, Susan E. Drozda, Kenneth R. Zasadny, Emily Miller, Lei Zhang, Kari R. Fonseca, Gabriela Barreiro, Patrick Trapa, Michelle Marie Claffey, Julie Cianfrogna, Marc B. Skaddan, Deborah L. Smith, Margaret M. Zaleska, Joshua R. Dunetz, Christopher L. Shaffer, Jessica Mancuso, Isao Sakurada, Gayatri Balan, Jamison B. Tuttle, Lois K. Chenard, Bruce N. Rogers, Matthew R. Reese, Antonia F. Stepan, Paul Galatsis, Brian P. Boscoe, Daniel P. Walker, Sarah Grimwood, Ann S. Wright, John T. Lazzaro, Karen J. Coffman, Laigao Chen
Publikováno v:
Journal of Medicinal Chemistry. 57:861-877
A novel series of pyrazolopyrazines is herein disclosed as mGluR5 negative allosteric modulators (NAMs). Starting from a high-throughput screen (HTS) hit (1), a systematic structure-activity relationship (SAR) study was conducted with a specific focu