The level of Ets-1 protein is regulated by poly(ADP-ribose) polymerase-1 (PARP-1) in cancer cells to prevent DNA damage.

Autor: Arnaud J Legrand, Souhaila Choul-Li, Corentin Spriet, Thierry Idziorek, Dorothée Vicogne, Hervé Drobecq, Françoise Dantzer, Vincent Villeret, Marc Aumercier

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e55883 (2013)

Ets-1 is a transcription factor that regulates many genes involved in cancer progression and in tumour invasion. It is a poor prognostic marker for breast, lung, colorectal and ovary carcinomas. Here, we identified poly(ADP-ribose) polymerase-1 (PARP

Externí odkaz: https://doaj.org/article/269959ef26424e268abc49222b335294

Ets-1 interacts through a similar binding interface with Ku70 and Poly (ADP-Ribose) Polymerase-1

Autor: Dorothée Vicogne, Marc Aumercier, Arnaud J. Legrand, Souhaila Choul-Li, Baptiste Bidon, Vincent Villeret

Publikováno v: Bioscience, Biotechnology and Biochemistry
Bioscience, Biotechnology and Biochemistry, Taylor & Francis, 2018, 82 (10), pp.1753-1759. ⟨10.1080/09168451.2018.1484276⟩
Bioscience, Biotechnology and Biochemistry, 2018, 82 (10), pp.1753-1759. ⟨10.1080/09168451.2018.1484276⟩

The Ets-1 transcription factor plays an important role in various physiological and pathological processes. These diverse roles of Ets-1 are likely to depend on its interaction proteins. We have previously showed that Ets-1 interacted with DNA-depend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19447ceff49d9f974d9fadd30930f620
https://hal.archives-ouvertes.fr/hal-02327208

Ets-1 p27: a novel Ets-1 isoform with dominant-negative effects on the transcriptional properties and the subcellular localization of Ets-1 p51

Autor: Denis Larsimont, Gabriel Leprivier, Agnès Begue, Martine Duterque-Coquillaud, Didier Monté, Clélia Laitem, Souhaila Choul-Li, Patrick Dumont, Marc Aumercier

The transcription factor Ets-1 is implicated in various physiological processes and invasive pathologies. We identified a novel variant of ets-1, ets-1Delta(III-VI), resulting from the alternative splicing of exons III to VI. This variant encodes a 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3da32f78e3c307ae44cb23b0b30dc03
https://ora.ox.ac.uk/objects/uuid:dc07b221-c647-48be-97c9-2ad44715c6d4

The caspase-generated cleavage product of Ets-1 p51 and Ets-1 p27, Cp17, induces apoptosis

Autor: Marc Aumercier, David Tulasne, Souhaila Choul-Li

Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2016, 480 (1), pp.1-7. ⟨10.1016/j.bbrc.2016.10.020⟩
Biochemical and Biophysical Research Communications, 2016, 480 (1), pp.1-7. ⟨10.1016/j.bbrc.2016.10.020⟩

The transcription factor Ets-1 is involved in various physiological processes and invasive pathologies. Human Ets-1 exists under three isoforms: p51, the predominant full-length isoform, p42 and p27, shorter alternatively spliced isoforms. We have pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ce965c2099511ec34c7c9f2368aa08
https://hal.archives-ouvertes.fr/hal-01604176

Caspase cleavage of Ets-1 p51 generates fragments with transcriptional dominant-negative function

Autor: Clélia Laitem, Gabriel Leprivier, Catherine Leroy, Souhaila Choul-Li, Marc Aumercier, David Tulasne

Publikováno v: Biochemical Journal
Biochemical Journal, Portland Press, 2010, 426 (2), pp.229-241. ⟨10.1042/BJ20090877⟩

Ets-1 is a transcription factor that plays an important role in various physiological and pathological processes, such as development, angiogenesis, apoptosis and tumour invasion. In the present study, we have demonstrated that Ets-1 p51, but not the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f96a194ee8197649f24dc4c095b8fa4
https://doi.org/10.1042/bj20090877