Natural killer cells and dendritic epidermal γδ T cells orchestrate type 1 conventional DC spatiotemporal repositioning toward CD8+ T cells

Autor: Sonia Ghilas, Marc Ambrosini, Jean-Charles Cancel, Carine Brousse, Marion Massé, Hugues Lelouard, Marc Dalod, Karine Crozat

Publikováno v: iScience, Vol 24, Iss 9, Pp 103059- (2021)

Summary: Successful immune responses rely on a regulated delivery of the right signals to the right cells at the right time. Here we show that natural killer (NK) and dendritic epidermal γδ T cells (DETCs) use similar mechanisms to spatiotemporally

Externí odkaz: https://doaj.org/article/d54b1b8a1b4c4075baf41ba89bea284f

Novel Cre-Expressing Mouse Strains Permitting to Selectively Track and Edit Type 1 Conventional Dendritic Cells Facilitate Disentangling Their Complexity in vivo

Autor: Raphaël Mattiuz, Christian Wohn, Sonia Ghilas, Marc Ambrosini, Yannick O. Alexandre, Cindy Sanchez, Anissa Fries, Thien-Phong Vu Manh, Bernard Malissen, Marc Dalod, Karine Crozat

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Type 1 conventional DCs (cDC1) excel in the cross-priming of CD8+ T cells, which is crucial for orchestrating efficient immune responses against viruses or tumors. However, our understanding of their physiological functions and molecular regulation h

Externí odkaz: https://doaj.org/article/b273b8922beb47cebccd18fc34d7b35e

Type 1 conventional dendritic cells and interferons are required for spontaneous CD4+ and CD8+ T‐cell protective responses to breast cancer

Autor: Karine Crozat, Christophe Caux, Marc Dalod, Marc Ambrosini, Carine Brousse, Jenny Valladeau-Guilemond, Gilles Bessou, Raphaël Mattiuz, Julie Mussard, Amélien Sanlaville, Nathalie Bendriss-Vermare, Jean-Charles Cancel

Publikováno v: Clinical & Translational Immunology, Vol 10, Iss 7, Pp n/a-n/a (2021)
Clinical and Translational Immunology
Clinical and Translational Immunology, 2021, 10, ⟨10.1002/cti2.1305⟩
Clinical and Translational Immunology, Nature Publishing Group, 2021, 10, ⟨10.1002/cti2.1305⟩

International audience; Objectives. To better understand how immune responses may be harnessed against breast cancer, we investigated which immune cell types and signalling pathways are required for spontaneous control of a mouse model of mammary ade

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1861702ca953e294eb42ad4c00831862
https://doaj.org/article/46b93295952c43ec864f593fc141e98b

NK cells orchestrate splenic cDC1 migration to potentiate antiviral protective CD8+ T cell responses

Autor: Karine Crozat, Marc Dalod, Jean-Charles Cancel, Marc Ambrosini, Sonia Ghilas, Marion Massé, Hugues Lelouard

SummaryA successful immune response relies on a tightly regulated delivery of the right signals to the right cells at the right time. Here we show that innate and innate-like lymphocytes use two mechanisms to orchestrate in time and space the functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a38d6bafaa229bb99bd4a62837f055e
https://hal.archives-ouvertes.fr/hal-02992494/file/2020.04.23.057463v1_for_CRAC.full.pdf

A PDGFRα-Mediated Switch toward CD9high Adipocyte Progenitors Controls Obesity-Induced Adipose Tissue Fibrosis

Autor: Judith Aron-Wisnewsky, Marc Ambrosini, Véronique Pelloux, Magali Fradet, Corneliu Henegar, Jean-Sébastien Hulot, Geneviève Marcelin, Raphael Nail-Barthelemy, Adaliene Versiani Matos Ferreira, Christine Rouault, Jean Christophe Bichet, Yuejun Liu, Christine Poitou, Yair Botbol, Karine Clément, Michael Atlan, Emmanuel L. Gautier, Adriana Torcivia

Publikováno v: Cell Metabolism. 25:673-685

Obesity-induced white adipose tissue (WAT) fibrosis is believed to accelerate WAT dysfunction. However, the cellular origin of WAT fibrosis remains unclear. Here, we show that adipocyte platelet-derived growth factor receptor-α-positive (PDGFRα+) p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e04338d8dcba8a17b295f43b339c070a
https://doi.org/10.1016/j.cmet.2017.01.010