Výsledky vyhledávání - "Marc A. Webster"

Elevated factor VIII is a risk factor for idiopathic venous thromboembolism in Canada – is it necessary to define a new upper reference range for factor VIII?

Autor: Nicole Langlois, Philip S. Wells, James Jaffey, Marc A. Webster, Josdalyne A. Anderson

Publikováno v: Thrombosis and Haemostasis. 93:842-846

SummaryPrevious studies suggest elevated factor VIII is a common, independent risk factor for venous thromboembolism (VTE); however, these studies included secondary and idiopathic VTE. We sought to explore the association between elevated factor VII

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be37791db218a03b7187357b94c1487
https://doi.org/10.1160/th05-01-0013

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pp60v- Induction of Cyclin D1 Requires Collaborative Interactions between the Extracellular Signal-regulated Kinase, p38, and Jun Kinase Pathways

Autor: Marc A. Webster, Giorgio Inghirami, Robert J. Stenger, Roger J. Davis, G K Haines, Genichi Watanabe, William J. Muller, Chris Albanese, Richard T. Lee, Richard G. Pestell, Joan S. Brugge

Publikováno v: Journal of Biological Chemistry. 274:7341-7350

The cyclin D1 gene is overexpressed in breast tumors and encodes a regulatory subunit of cyclin-dependent kinases that phosphorylate the retinoblastoma protein. pp60c-src activity is frequently increased in breast tumors; however, the mechanisms gove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb10290b636ec8a6b0748d89426a8331
https://doi.org/10.1074/jbc.274.11.7341

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Reciprocal Regulation of Neu Tyrosine Kinase Activity and Caveolin-1 Protein Expression in Vitro and in Vivo

Autor: Michael P. Lisanti, Jeffrey A. Engelman, Jolene J. Windle, Richard G. Pestell, David J. Bearss, William J. Muller, Anthony N. Karnezis, Richard T. Lee, Marc A. Webster, Peter M. Siegel

Publikováno v: Journal of Biological Chemistry. 273:20448-20455

Neu (c-erbB2) is a proto-oncogene product that encodes an epidermal growth factor-like receptor tyrosine kinase. Amplification of wild-type c-Neu and mutational activation of Neu (Neu T) have been implicated in oncogenic transformation of cultured fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cce4728c4b011cf8c10e8424aec4c5f3
https://doi.org/10.1074/jbc.273.32.20448

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Induction of mammary epithelial hyperplasias and mammary tumors in transgenic mice expressing a murine mammary tumor virus/activated c-src fusion gene

Autor: Robert D. Cardiff, Marc A. Webster, William J. Muller

Publikováno v: Proceedings of the National Academy of Sciences. 92:7849-7853

Activation of the c-Src tyrosine kinase has been implicated as an important step in the induction of mammary tumors in both mice and humans. To directly assess the effect of mammary gland-specific expression of activated c-Src, we established transge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68fd8921bab66426214639b9285def67
https://doi.org/10.1073/pnas.92.17.7849

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Histopathology of transgenic mouse mammary tumors (a short atlas)

Autor: William J. Muller, Marc A. Webster, Robert J. Munn, Robert D. Cardiff

Publikováno v: Seminars in Cancer Biology. 6:153-158

Mammary hyperplasias, dysplasias and tumors have been described in many strains of transgenic mice. Many of the transgenes produce characteristic disturbances of growth, development and neoplasia. The disturbances can now be classified into groups. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f83e6781e994c15ca2044176aec36e8
https://doi.org/10.1006/scbi.1995.0020

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Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity

Autor: Marc A. Webster, David Dankort, Senthil K. Muthuswamy, William J. Muller, Peter M. Siegel

Publikováno v: Molecular and Cellular Biology. 14:735-743

Amplification and overexpression of the neu (c-erbB2) proto-oncogene has been implicated in the pathogenesis of 20 to 30% of human breast cancers. Although the activation of Neu receptor tyrosine kinase appears to be a pivotal step during mammary tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd4ce1628757126cb224d748a811e4ab
https://doi.org/10.1128/mcb.14.1.735

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Classified Advertising Rates That Vary by Category

Autor: Marc P. Webster, James G. Mulligan

Publikováno v: International Journal of Advertising. 13:185-193

This article considers the profit potential of exploiting the differences in demand for separate categories of classified advertisements. We report results of an empirical study of the pricing behaviour of a random sample of US newspapers. We find th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74f726a7dd7e458f6cf0075604dfd0b2
https://doi.org/10.1080/02650487.1994.11104571

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The induction of uterine leiomyomas and mammary tumors in transgenic mice expressing polyomavirus (PyV) large T (LT) antigen is associated with the ability of PyV LT antigen to form specific complexes with retinoblastoma and CUTL1 family members

Autor: William J. Muller, Nathalie Martin-Soudant, Alain Nepveu, Robert D. Cardiff, Marc A. Webster

Publikováno v: Oncogene. 16(15)

The inactivation of certain tumor suppressor genes is thought to play an important role in the genesis of a number of tumor types. For example, inactivation of the Retinoblastoma (Rb) tumor suppressor is frequently observed in a proportion of sporadi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff29125039d4e56f4f86d5de5ece0a3
https://pubmed.ncbi.nlm.nih.gov/9591780

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Requirement for Both Shc and Phosphatidylinositol 3′ Kinase Signaling Pathways in Polyomavirus Middle T-Mediated Mammary Tumorigenesis

Autor: Michael J. Rauh, Christopher G. Tortorice, Frank L. Graham, Martina Anton, William J. Muller, John N. Hutchinson, Robert D. Cardiff, Marc A. Webster, John A. Hassell, Senthil K. Muthuswamy

Transgenic mice expressing the polyomavirus (PyV) middle T antigen (MT) develop multifocal mammary tumors which frequently metastasize to the lung. The potent transforming activity of PyV MT is correlated with its capacity to activate and associate w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e07cd9178fb8482a9b37eed1f3007c3
https://europepmc.org/articles/PMC121489/

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