Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Marc A. Terranova"'
Autor:
Brenda Martino, Diana L. Donnelly-Roberts, Jill M. Wetter, Marie E. Uchic, Kennan C. Marsh, Ahmed A. Hakeem, Sherry Nelson, Teodozyj Kolasa, Gin C. Hsieh, Odile F. El-Kouhen, Kathleen H. Mortell, Rohde Jeffrey J, Meena V. Patel, Ruth L. Martin, Marlon D. Cowart, Peter R. Hollingsworth, Marc A. Terranova, Andrew O. Stewart, Robert B. Moreland, and Jorge D. Brioni, Mark A. Matulenko, Loan N. Miller, Gary A. Gintant, James P. Sullivan, Marian T. Namovic, John F. Darbyshire, Renjie Chang, Masaki Nakane
Publikováno v:
Journal of Medicinal Chemistry. 49:7450-7465
The goal of this study was to identify a structurally distinct D(4)-selective agonist with superior oral bioavailability to our first-generation clinical candidate 1a (ABT-724) for the potential treatment of erectile dysfunction. Arylpiperazines such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f481cffca5c5c281238800552907e71e
https://doi.org/10.1021/jm060662k
https://doi.org/10.1021/jm060662k
Autor:
Renjie Chang, Marc A. Terranova, Masaki Nakane, Andrew O. Stewart, Leimin Fan, Marian T. Namovic, Loan N. Miller, Robert B. Moreland, Teodozyi Kolasa, Diana L. Donnelly-Roberts, Bruce Surber, Marie E. Uchic, Jorge D. Brioni, Mark A. Matulenko
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:5095-5098
The first selective dopamine D4 agonist radioligand is described. The synthesis of these piperazine radioligands relied on the transformation of brominated precursors 4a and 4b with tritium gas in the presence of a sensitive cyano functional group. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c470e316da91603cb5ee93a2ac2d76
https://doi.org/10.1016/j.bmcl.2004.07.068
https://doi.org/10.1016/j.bmcl.2004.07.068
Autor:
Earl J. Gubbins, Loan N. Miller, Marc A. Terranova, Robert B. Moreland, Jeffrey N. Masters, Odile F. El-Kouhen, Diana L. Donnelly-Roberts, Marie E. Uchic, Jorge D. Brioni, Marian T. Namovic, Rosalind J. Helfrich, Renjie Chang, Masaki Nakane
Publikováno v:
Biochemical Pharmacology. 68:761-772
The goal of this study was to develop a new approach to study the pharmacology of the dopamine D 4 receptor that could be used in comparative studies with dopamine D 2 and D 3 receptors. Stable HEK-293 cell lines co-expressing recombinant human D 2L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818abcb51ef171c8a2755e5167e2b4e7
https://doi.org/10.1016/j.bcp.2004.05.019
https://doi.org/10.1016/j.bcp.2004.05.019
Autor:
Renjie Chang, Marie E. Uchic, Jorge D. Brioni, Bruce W. Surber, Andrew O. Stewart, Marc A. Terranova, Robert B. Moreland, Mark A. Matulenko
Publikováno v:
European Journal of Pharmacology. 497:147-154
Tritiation of the dopamine D(4) receptor selective agonist A-369508 ([2-[4-(2-cyanophenyl)-1-piperazinyl]-N-(3-methylphenyl) acetamide) has provided a radioligand for the characterization of dopamine D(4) receptors. [(3)H] A-369508 binds with high af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716d5dee7fd2e0a3c36e3dc66e69293e
https://doi.org/10.1016/j.ejphar.2004.06.049
https://doi.org/10.1016/j.ejphar.2004.06.049
Autor:
Teodozyj Kolasa, Kathleen Mortell, Renje Chang, Jorge D. Brioni, Meena V. Patel, Marc A. Terranova, Brenda Martino, Masaki Nakane, Robert B. Moreland, Odile F. El Kouhen, Andrew O. Stewart, Marian T. Namovic, Pramila Bhatia, Mark A. Matulenko, Diana L. Donnelly-Roberts, Peter R. Hollingsworth, Marie E. Uchic, Loan N. Miller, Kennan C. Marsh, Gin C. Hsieh, Rodger F. Henry, Ahmed A. Hakeem, Jill M. Wetter
Publikováno v:
Journal of medicinal chemistry. 49(17)
A new series of dopamine D4 receptor agonists, 1-aryl-3-(4-pyridinepiperazin-1-yl)propanone oximes, was designed through the modification of known dopamine D4 receptor agonist PD 168077. Replacement of the amide group with a methylene-oxime moiety pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e50ed5e8c7b8542a2808ed29eccec91
https://pubmed.ncbi.nlm.nih.gov/16913699
https://pubmed.ncbi.nlm.nih.gov/16913699
Autor:
Marc A. Terranova, Kennan C. Marsh, Diana L. Donnelly-Roberts, Gin C. Hsieh, Robert B. Moreland, Marie E. Uchic, Marlon D. Cowart, Jill M. Wetter, Andrew O. Stewart, Loan N. Miller, Thomas R. Miller, Marian T. Namovic, Jorge D. Brioni, Renjie Chang, Masaki Nakane
Publikováno v:
Neuropharmacology. 49(1)
2-[4-(3,4-Dimethylphenlyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393) was identified as a potent dopamine D4 receptor antagonist with excellent receptor selectivity. [3H]-spiperone competition binding assays showed that A-381393 potently bound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3938cda40cac3506b3f44158272419c4
https://pubmed.ncbi.nlm.nih.gov/15992586
https://pubmed.ncbi.nlm.nih.gov/15992586
Autor:
Diana L. Donnelly-Roberts, Marlon D. Cowart, Marie E. Uchic, Peter R. Hollingsworth, Pramila Bhatia, Meena V. Patel, Renjie Chang, Rohde Jeffrey J, Sherry L. Nelson, Marc A. Terranova, Masaki Nakane, Brenda R. Martino, James P. Sullivan, Loan N. Miller, Steven P. Latshaw, Andrew O. Stewart, Jorge D. Brioni, Robert B. Moreland, Marian T. Namovic, Teodozyi Kolasa, James J. Lynch, Jerome F. Daanen, Gin C. Hsieh
Publikováno v:
Journal of medicinal chemistry. 47(15)
A new class of agents with potential utility for the treatment of erectile dysfunction has been discovered, guided by the hypothesis that selective D4 agonists are erectogenic but devoid of the side effects typically associated with dopaminergic agen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7920690f9690b69b428e2fdb87bd5883
https://pubmed.ncbi.nlm.nih.gov/15239663
https://pubmed.ncbi.nlm.nih.gov/15239663
Autor:
Diana L. Donnelly-Roberts, Jerome F. Daanen, Robert B. Moreland, Marlon D. Cowart, Marc A. Terranova, Jorge D. Brioni, Masaki Nakane, Pramila Bhatia, Sherry L. Nelson, Marian T. Namovic, Mark A. Matulenko, and James P. Sullivan, Xueqing Wang, Latshaw Steve, Loan N. Miller, Andrew O. Stewart
Publikováno v:
Journal of medicinal chemistry. 47(9)
A series of subtype selective dopamine D(4) receptor ligands from the hetroarylmethylphenylpiperazine class have been discovered that exhibit a remarkable structure-activity relationship (SAR), revealing a substituent effect in which regiosubstitutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29a5392461527d7a44b020120756ece
https://pubmed.ncbi.nlm.nih.gov/15084133
https://pubmed.ncbi.nlm.nih.gov/15084133
Autor:
Ahmed A. Hakeem, Marc A. Terranova, Masaki Nakane, Diana L. Donnelly-Roberts, Mark A. Matulenko, Jorge D. Brioni, Marie E. Uchic, Andrew O. Stewart, Renjie Chang, Teodozyi Kolasa, Marian T. Namovic, Loan N. Miller, Robert B. Moreland
Publikováno v:
Bioorganicmedicinal chemistry. 12(13)
Diaryl piperazine acetamides were identified as potent and selective dopamine D(4) receptor agonists. Our strategy is based on an amide bond reversal of an acid sensitive, dopamine D(4) receptor partial agonist, PD 168077. This reversal provided comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0fd32e864d9ee769a43035aef8655e3
https://pubmed.ncbi.nlm.nih.gov/15186832
https://pubmed.ncbi.nlm.nih.gov/15186832
Autor:
James J. Lynch, Renjie Chang, Peter R. Hollingsworth, Joseph P. Mikusa, Kennan C. Marsh, Gin C. Hsieh, Jill M. McVey, Alyssa B. O'Neill, Teodozyi Kolasa, Diana L. Donnelly-Roberts, Marc A. Terranova, Brenda R. Martino, James P. Sullivan, Jorge D. Brioni, Robert B. Moreland
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 308(1)
Apomorphine has been used as a pharmacological probe of dopaminergic receptors in a variety of central nervous system disorders. The utility of apomorphine as an agent for the treatment of erectile dysfunction has also been demonstrated clinically. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205fd3711bc6273364b309c7303538fa
https://pubmed.ncbi.nlm.nih.gov/14569075
https://pubmed.ncbi.nlm.nih.gov/14569075