Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Marc A. Longino"'
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Akademický článek
Effect of Polar Head Group Modifications on the Tumor Retention of Phospholipid Ether Analogs: Role of the Quaternary Nitrogen
Autor: Anatoly N. Pinchuk, Mark A. Rampy, Marc A. Longino, Ben Y. Durkee, Raymond E. Counsell, Jamey P. Weichert
Publikováno v: Pharmaceutics, Vol 15, Iss 1, p 171 (2023)
We have previously described the remarkable capacity of radioiodinated alkyl phospholipids to be sequestered and retained by a variety of tumors in vivo. We have already established the influence of certain structural parameters of iodinated alkyl ph
Externí odkaz: https://doaj.org/article/3e141f81514940b6a70570fd671b817b
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Quantification of CLR1401, a novel alkylphosphocholine anticancer agent, in rat plasma by hydrophilic interaction liquid chromatography–tandem mass spectrometric detection
Autor: Jamey P. Weichert, Maria Banach, Richard Tollefson, Qin C. Ji, Giangthy N. Ton, Michelle J. Cannon, Christie Scheuerell, Xiangyu Jiang, William R. Clarke, Hongliang Jiang, Anatoly Pinchuk, Marc A. Longino
Publikováno v: Journal of Chromatography B. 878:1513-1518
A rapid and specific LC-MS/MS based bioanalytical method was developed and validated for the determination of 18-(p-iodophenyl)octadecyl phosphocholine (CLR1401), a novel phosphocholine drug candidate, in rat plasma. The optimal chromatographic behav
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7cdaf33a731f5d1790f5ae39afa169
https://doi.org/10.1016/j.jchromb.2010.04.002
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Lipid-based blood-pool CT imaging of the liver
Autor: Jamey P. Weichert, Fred T. Lee, Marc A. Longino, Raymond E. Counsell, Susan G. Chosy
Publikováno v: Academic Radiology. 5:S16-S19
Rationale and Objectives. We have recently developed an iodinated lipid-based contrast agent capable of residing in the blood pool for extended periods of time relative to conventional water-soluble contrast agents. The purpose of this study was to e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d3c480d8daf6c78526362e742d8172
https://doi.org/10.1016/s1076-6332(98)80047-0
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4
Computed tomography scanning of morris hepatomas with liver-specific polyiodinated triglycerides
Autor: Fred T. Lee, Jamey P. Weichert, Marc A. Longino, Raymond E. Counsell, Michael G. Spigarelli, Susan W. Schwendner
Publikováno v: Academic Radiology. 3:412-417
Rationale and Objectives. We compared the computed tomography (CT) scanning characteristics of a polyiodinated triglyceride analog with those of a urographic agent to distinguish Morris-7777 hepatoma (MH) cells from normal hepatocytes in rats. Method
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc10696c6f287b94fd65feacf1d5ca2
https://doi.org/10.1016/s1076-6332(05)80676-2
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6
Potential organ or tumor imaging agents. 32. A triglyceride ester of P-Iodophenyl pentadecanoic acid as a potential hepatic imaging agent
Autor: Jamey P. Weichert, Susan W. Schwendner, Milton D. Gross, Marc A. Longino, Raymond E. Counsell
Publikováno v: International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology. 19:639-650
A triglyceride analog, glycerol-2-palmitoyl-1,3-di-15-(p-iodophenyl)pentadecanoate (DPPG) was synthesized and radiolabeled for evaluation as a potential functional liver scintigraphic agent. Uptake of DPPG was compared in normal, diabetic, tumor-bear
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5e29b42415be35e6e1a103f04a9b03
https://doi.org/10.1016/0883-2897(92)90098-j
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Biotinylated granulocyte/macrophage colony-stimulating factor analogs: effect of linkage chemistry on activity and binding
Autor: Marc A. Longino, Michael F. Clarke, Timothy Angelotti, Stephen G. Emerson
Publikováno v: Bioconjugate Chemistry. 2:466-474
Biotinylated granulocyte/macrophage colony-stimulating factor (GM-CSF) analogues with different linkage chemistries and levels of conjugated biotin were synthesized by reacting recombinant human GM-CSF with sulfosuccinimidyl 6-biotinamidohexanoate or
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e61cffe267d29cb488918ff2f011b3d
https://doi.org/10.1021/bc00012a016
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8
Abberations in Phospholipase D Activity‐A Pharmacological Target for Cancer Detection
Autor: Jamey P. Weichert, Marc A. Longino, Poh Hui Chia, Sharon M. Weber, Patrick J. Kenney
Publikováno v: The FASEB Journal. 20
Understanding molecular targets and developing novel molecular imaging agents can improve early cancer detection. Radioiodinated NM404, a phospholipid ether analog in clinical trials, displays sele...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92ac1b49191f9243c8d6adbbc40ec31e
https://doi.org/10.1096/fasebj.20.4.a488
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9
Methoxypoly(ethylene glycol)-conjugated carboxypeptidase A for solid tumor targeting: part II: pharmacokinetics and biodistribution in normal and tumor-bearing rodents
Autor: Giangthy N, Ton, Jamey P, Weichert, Marc A, Longino, Jason P, Fine, Glen S, Kwon
Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 104(1)
We have evaluated effects of mPEG modification on pharmacokinetic properties of carboxypeptidase A (CPA) in normal rats. Attachment of two or three mPEG chains to CPA resulted in the generation of mPEG2-CPA and mPEG3-CPA analogs with significantly en
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::366dddb4cb0b163028274ef32501dfa9
https://pubmed.ncbi.nlm.nih.gov/15866342
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