Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Marc A. Gavin"'
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Hemophilia A is a genetic disorder that results in the deficiency of functional factor VIII protein, which plays a key role in blood coagulation. Currently, the majority of hemophilia A patients are treated with repeated infusions of factor VIII prot
Externí odkaz:
https://doaj.org/article/976afe11dda64acca341ca8c2ea41dc0
Publikováno v:
J Immunol
IL-2 is a critical regulator of immune homeostasis through its impact on both regulatory T (Treg) and effector T cells. However, the precise role of IL-2 in the maintenance and function of Treg cells in the adult peripheral immune system remains uncl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d8c15a81c5fa4aac37fb361114574c
https://doi.org/10.4049/jimmunol.1901520
https://doi.org/10.4049/jimmunol.1901520
Autor:
Liliane Khoryati, Jenna M. Sullivan, Braxton L. Jamison, Erika Hayes, Minh Nguyet Pham, Daniel J. Campbell, Marc A. Gavin
Publikováno v:
ImmunoHorizons. 5(9)
In mice, Ag administration in the absence of adjuvant typically elicits tolerogenic immune responses through the deletion or inactivation of conventional CD4 T cells and the formation or expansion of regulatory CD4 T cells (Treg). Although these “A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e3b3decc08c4f8a609b3e3d713a6d9
https://pubmed.ncbi.nlm.nih.gov/34583939
https://pubmed.ncbi.nlm.nih.gov/34583939
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
Hemophilia A is a genetic disorder that results in the deficiency of functional factor VIII protein, which plays a key role in blood coagulation. Currently, the majority of hemophilia A patients are treated with repeated infusions of factor VIII prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82019b9dc3e5c33b962d852952aae91
https://www.frontiersin.org/article/10.3389/fimmu.2020.00638/full
https://www.frontiersin.org/article/10.3389/fimmu.2020.00638/full
Autor:
McKenna Sherve, Marc A. Gavin, Daniel J. Campbell, Liliane Khoryati, Kevin Cook, Josh T. Pearson, Marika Bogdani, Minh Nguyet Pham, Swarnima Kumari
Publikováno v:
Sci Immunol
Interleukin-2 (IL-2) controls the homeostasis and function of regulatory T (Treg) cells, and defects in the IL-2 pathway contribute to multiple autoimmune diseases. Although recombinant IL-2 therapy has been efficacious in certain inflammatory condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366c92c1e5819e9cb98d5013d0e86939
https://pubmed.ncbi.nlm.nih.gov/32817295
https://pubmed.ncbi.nlm.nih.gov/32817295
Autor:
Josh T. Pearson, Minh Nguyet Pham, Sherve M, Marika Bogdani, Swarnima Kumari, Daniel J. Campbell, Marc A. Gavin, Kevin Cook, Liliane Khoryati
Interleukin-2 (IL-2) controls the homeostasis and function of regulatory T cells (Tregs) and defects in the IL-2 pathway contribute to multiple autoimmune diseases. Although recombinant IL-2 therapy has been efficacious in certain inflammatory condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c48381109ed19d8db5511566c1f3b8c
Autor:
Alex Rohde, Tim Sexton, Erik Espling, George A. Gaitanaris, Christiana Doulami, Alexander Gragerov, Marc A. Gavin
Publikováno v:
Cancer Immunology Research. 8:B45-B45
Extracellular phosphatidylserine (PS) is a potent modulator of immune responses. Various phospholipid scramblases respond to different cellular processes to expose PS either during apoptosis or during activation of multiple cell types, including plat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88d6c7453d2d3fd77199c33e18c202ce
https://doi.org/10.1158/2326-6074.tumimm19-b45
https://doi.org/10.1158/2326-6074.tumimm19-b45
Publikováno v:
Diabetes. 67
Regulatory T cells (Treg) play a pivotal role in maintaining self-tolerance. For their development and function, Treg rely on interleukin-2 (IL-2) and efficiently compete with other immune cells for IL-2 by expressing the highest levels of the IL-2 r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d34907ba00263edfd76a7b793b14c21d
https://doi.org/10.2337/db18-314-or
https://doi.org/10.2337/db18-314-or
Autor:
Gang Yu, Ming Zhang, John Babcook, Joshua T. Pearson, John M. Delaney, Ai Ching Lim, Brian Mingtung Chan, Marc A. Gavin, Palaniswami Rathanaswami, Hailing Hsu
Publikováno v:
Arthritis & Rheumatology. 67:2723-2731
Objective Systemic lupus erythematosus (SLE) is a complex autoimmune disease that is driven in part by chronic B and T lymphocyte hyperresponsiveness to self antigens. A deficiency of interleukin-21 (IL-21) or IL-21 receptor (IL-21R) in mice dramatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::919f0a82967717b17d0feea9b50bbf75
https://doi.org/10.1002/art.39233
https://doi.org/10.1002/art.39233
Autor:
Katharine Schwedhelm, Jane H. Buckner, Marc A. Gavin, Karen Cerosaletti, Jerill Thorpe, Cate Speake, S. Alice Long, Sara A. Murray, Carla J. Greenbaum
Publikováno v:
Clinical immunology (Orlando, Fla.). 181
The IL-2/IL-2R pathway is implicated in type 1 diabetes (T1D). While its role in regulatory T cell (Treg) biology is well characterized, mechanisms that influence IL-2 responses in effector T cells (Teff) are less well understood. We compared IL-2 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05f6d8e4e2e919b0bd963b002e37361
https://pubmed.ncbi.nlm.nih.gov/28645874
https://pubmed.ncbi.nlm.nih.gov/28645874