Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Marc A Beal"'
Autor:
Marc A. Beal, Matthew J. Meier, Angela Dykes, Carole L. Yauk, Iain B. Lambert, Francesco Marchetti
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108407- (2023)
Summary: The lacZ gene of Escherichia coli encodes β-galactosidase (β-gal), a lactose metabolism enzyme of the lactose operon. Previous chemical modification or site-directed mutagenesis experiments have identified 21 amino acids that are essential
Externí odkaz:
https://doaj.org/article/82d55d46550040ffb5076b89459ea282
Autor:
Marc A. Beal, Logan J. Everett
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
Externí odkaz:
https://doaj.org/article/bf1b3d8bbed9496a89b5981bcf13482c
Autor:
Byron Kuo, Marc A. Beal, John W. Wills, Paul A. White, Francesco Marchetti, Andy Nong, Tara S. Barton-Maclaren, Keith Houck, Carole L. Yauk
Publikováno v:
Archives of Toxicology. 96:2067-2085
Funder: Canada Research Chairs; doi: http://dx.doi.org/10.13039/501100001804
Risk assessments are increasingly reliant on information from in vitro assays. The in vitro micronucleus test (MNvit) is a genotoxicity test that detects chromosomal ab
Risk assessments are increasingly reliant on information from in vitro assays. The in vitro micronucleus test (MNvit) is a genotoxicity test that detects chromosomal ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6a452403e942c033b914391c3e0fdc
https://doi.org/10.1007/s00204-022-03286-2
https://doi.org/10.1007/s00204-022-03286-2
Autor:
Geronimo Matteo, Karen Leingartner, Andrea Rowan-Carroll, Matthew Meier, Andrew Williams, Marc A Beal, Matthew Gagné, Reza Farmahin, Shamika Wickramasuriya, Anthony J F Reardon, Tara Barton-Maclaren, J Christopher Corton, Carole L Yauk, Ella Atlas
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology.
Since initial regulatory action in 2010 in Canada, bisphenol A (BPA) has been progressively replaced by structurally related alternative chemicals. Unfortunately, many of these chemicals are data-poor, limiting toxicological risk assessment. We used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49bb89ddb4c821bed7af8bacb09441a
https://pubmed.ncbi.nlm.nih.gov/36534918
https://pubmed.ncbi.nlm.nih.gov/36534918
Autor:
Marc A. Beal, Marc Audebert, Tara Barton‐Maclaren, Hannah Battaion, Jeffrey C. Bemis, Xuefei Cao, Connie Chen, Stephen D. Dertinger, Roland Froetschl, Xiaoqing Guo, George Johnson, Giel Hendriks, Laure Khoury, Alexandra S. Long, Stefan Pfuhler, Raja S. Settivari, Shamika Wickramasuriya, Paul White
Publikováno v:
Environmental and molecular mutagenesis, Early View
Genotoxicity assessment is a critical component in the development and evaluation of chemicals. Traditional genotoxicity assays (i.e., mutagenicity, clastogenicity, aneugenicity) have been limited to dichotomous hazard classification, while other tox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a6d59ccfacfcd3ddb681a0a6174ca8
https://pubmed.ncbi.nlm.nih.gov/36495195
https://pubmed.ncbi.nlm.nih.gov/36495195
Autor:
Carole L. Yauk, Francesco Marchetti, Danielle P. LeBlanc, Clotilde Maurice, Jason M. O'Brien, Matthew J. Meier, Marc A. Beal
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Communications Biology
Communications Biology
Transgenic rodent (TGR) models use bacterial reporter genes to quantify in vivo mutagenesis. Pairing TGR assays with next-generation sequencing (NGS) enables comprehensive mutation pattern analysis to inform mutational mechanisms. We used this approa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8e7c5302f256366ffd5c3bb8508f62
http://link.springer.com/article/10.1038/s42003-020-01174-y
http://link.springer.com/article/10.1038/s42003-020-01174-y
Autor:
Xiaotong Wang, Trang Luu, Marc A Beal, Tara S Barton-Maclaren, Bernard Robaire, Barbara F Hales
Publikováno v:
Toxicol Sci
The replacement of regulated brominated flame retardants and plasticizers with organophosphate esters (OPEs) has led to their pervasive presence in the environment and in biological matrices. Further, there is evidence that exposure to some of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c55406e49f8c5097aa3fbb119f28a7
https://europepmc.org/articles/PMC8963303/
https://europepmc.org/articles/PMC8963303/
Autor:
Byron, Kuo, Marc A, Beal, John W, Wills, Paul A, White, Francesco, Marchetti, Andy, Nong, Tara S, Barton-Maclaren, Keith, Houck, Carole L, Yauk
Publikováno v:
Archives of toxicology. 96(7)
Risk assessments are increasingly reliant on information from in vitro assays. The in vitro micronucleus test (MNvit) is a genotoxicity test that detects chromosomal abnormalities, including chromosome breakage (clastogenicity) and/or whole chromosom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4dda6f097926ea86511c21ba0029e64a
https://pubmed.ncbi.nlm.nih.gov/35445829
https://pubmed.ncbi.nlm.nih.gov/35445829
Autor:
Sunil Kulkarni, Matthew Gagne, Deborah Ramsingh, Tara S. Barton-Maclaren, Yadvinder Bhuller, Marc A. Beal
Publikováno v:
Frontiers in Toxicology, Vol 3 (2021)
In 2012, the Council of Canadian Academies published the expert panel on integrated testing of pesticide’s report titled: Integrating emerging technologies into chemical safety assessment. This report was prepared for the Government of Canada in re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e2492bbbf20e5b24a6f71ec79c723b
https://www.frontiersin.org/articles/10.3389/ftox.2021.748406/full
https://www.frontiersin.org/articles/10.3389/ftox.2021.748406/full
Autor:
Frank Bringezu, Phillip Bellion, Alexander Amberg, Jeffrey M. Birmingham, Alejandra Trejo-Martin, Glenn J. Myatt, Amy L. Mihalchik-Burhans, Amarjit Luniwal, Naomi L. Kruhlak, Rosalie K. Elespuru, Karen H. Watanabe-Sailor, Louise Neilson, Lidia Ceriani, Markus Frericks, Alessandro Brigo, John P. Rooney, Arun R. Pandiri, Helga Gerets, Alice Luu, Arianna Bassan, Angela White, Marc A. Beal, Federica Madia, Manuela Pavan, David Faulkner, Lennart T. Anger, Elena Lo Piparo, Marie C. Fortin, Jordi Mestres, Ian Crooks, David Woolley, Raymond R. Tice, Paul Fowler, Balasubramanian Manickam, David R. Jones, Cynthia V. Rider, Serena Manganelli, Juan Lopez-Belmonte, Gloria D. Jahnke, Kevin P. Cross, Romualdo Benigni
Publikováno v:
Comput Toxicol
Historically, identifying carcinogens has relied primarily on tumor studies in rodents, which require enormous resources in both money and time. In silico models have been developed for predicting rodent carcinogens but have not yet found general reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de085dd3094d276c69682e6dfe5bb402
https://europepmc.org/articles/PMC8967183/
https://europepmc.org/articles/PMC8967183/