Semisynthetic Di- and Tri-Functionalized Non-Immunosuppressive Cyclosporin A Derivatives as Potential Anti-HIV 1 Drugs

Autor: Georges Bashiardes, Jean-Christophe Gueguen, Bruno Filoche, Jean-Christophe Carry, Marc Vuilhorgne, Serge Mignani, Jean-Claude Barriere, Claude Bensoussan, Serge Sablé, Norbert Dereu, Michel Evers

Publikováno v: Scopus-Elsevier

A regio- and stereoselective synthesis of original semisynthetic di- and tri-functionalized non-immunosuppressive cyclosporins by way of a Barton ester decarboxylation and a C-thioalkylation starting from cyclosporin A (CsA) and [4'-hydroxy-MeLeu] 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867678b00bab387e791d0b4f13a1e4ab
https://doi.org/10.1055/s-2004-815405

Solid phase β-lactams synthesis using the Staudinger reaction, monitored by 19F NMR spectroscopy

Autor: Serge Mignani, Dominique Mouysset, Lucien Stella, Marc Vuilhorgne, Isabelle Le Roy

Publikováno v: Tetrahedron. 59:3719-3727

We report the use of 19 F NMR as a simple means to monitor reactions on a solid phase. Multi-step sequences including protection, coupling, deprotection, condensation, cycloaddition and cleavage steps are described in the case of multicomponent react

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17410460383c8964e2f10af3ccbcc3af
https://doi.org/10.1016/s0040-4020(03)00553-2

Regiospecific Inverse-Electron-Demand Diels-Alder Reaction of Simultaneously Electrogenerated Diene and Dienophile: An Expeditious Route to Polyfunctionalized 1,4-Benzoxazine Derivatives

Autor: Marc Vuilhorgne, Anne Neudorffer, Martine Largeron, Maurice-Bernard Fleury, Estelle Blattes

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2002, 41 (5), pp.824. ⟨10.1002/1521-3773(20020301)41:53.0.co;2-z⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5053225561a958ce4760c33461751f29
https://doi.org/10.1002/1521-3757(20020301)114:5<852::aid-ange852>3.0.co

Bioisosteres of 9-Carboxymethyl-4-oxo-imidazo[1,2- a ]indeno[1,2- e ]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent In Vivo AMPA antagonists with longer durations of action

Autor: Arielle Genevois-Borella, Georg Andrees Bohme, Franco Manfre, Alain Boireau, Yves Ribeill, Marc Williams Debono, Patrick Jimonet, Jean-Marie Stutzmann, Jeremy Pratt, Dominique Damour, Jean Bouquerel, Philippe Hubert, Marc Vuilhorgne, John Randle, Patrick Nemecek, Jean-Claude Hardy, Serge Mignani

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 11:127-132

A novel series of 2- and 9-disubstituted heterocyclic-fused 4-oxo-indeno[1,2- e ]pyrazin derivatives was synthesized. One of them, the 9-(1 H -tetrazol-5-ylmethyl)-4-oxo-5,10-dihydroimidazo[1,2- a ]indeno[1,2- e ]pyrazin-2-yl phosphonic acid 4i exhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ac0e92b179b6bdf461d575d0a942d3
https://doi.org/10.1016/s0960-894x(00)00592-8

8-Methylureido-10-amino-10-methyl-imidazo[1,2- a ]indeno[1,2- e ]pyrazine-4-ones: Highly In vivo Potent and Selective AMPA Receptor Antagonists

Autor: Jean-Marie Stutzmann, Marc Williams Debono, Alain Boireau, Arielle Genevois-Borella, Michel Cheve, Dominique Damour, Assunta Imperato, John Randle, Yves Ribeill, Jeremy Pratt, Serge Mignani, Patrick Jimonet, Marc Vuilhorgne, Georg Andrees Bohme

Publikováno v: Bioorganic & Medicinal Chemistry. 8:2211-2217

Water soluble 8-methylureido-10-amino-10-methyl-imidazo[1,2-a]indeno[1,2-e]pyraz ine-4-one 4 represents a novel class of highly potent and selective AMPA receptors antagonists with in vivo activity. The dextrorotatory isomer (+)-4 was found to displa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675b2882dda673cbc94a2c3686682c41
https://doi.org/10.1016/s0968-0896(00)00161-9