Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Marc, Ruff"'
Autor:
José Rivera Alvarez, Laure Asselin, Peggy Tilly, Roxane Benoit, Claire Batisse, Ludovic Richert, Julien Batisse, Bastien Morlet, Florian Levet, Noémie Schwaller, Yves Mély, Marc Ruff, Anne-Cécile Reymann, Juliette D. Godin
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112744- (2023)
Summary: Completion of neuronal migration is critical for brain development. Kif21b is a plus-end-directed kinesin motor protein that promotes intracellular transport and controls microtubule dynamics in neurons. Here we report a physiological functi
Externí odkaz:
https://doaj.org/article/b4ba44d3e5c544848a643fbb11dedca7
Autor:
Robert Drillien, Karine Pradeau-Aubreton, Julien Batisse, Joëlle Mezher, Emma Schenckbecher, Justine Marguin, Eric Ennifar, Marc Ruff
Publikováno v:
PLoS ONE, Vol 17, Iss 12 (2022)
The production of full length, biologically active proteins in mammalian cells is critical for a wide variety of purposes ranging from structural studies to preparation of subunit vaccines. Prior research has shown that Modified vaccinia virus Ankara
Externí odkaz:
https://doaj.org/article/4bffa090bb394c638e1fc7682e2c2baa
Autor:
Cecilia Rocchi, Camille Louvat, Adriana Erica Miele, Julien Batisse, Christophe Guillon, Lionel Ballut, Daniela Lener, Matteo Negroni, Marc Ruff, Patrice Gouet, Francesca Fiorini
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 13742 (2022)
Recent evidence indicates that the HIV-1 Integrase (IN) binds the viral genomic RNA (gRNA), playing a critical role in the morphogenesis of the viral particle and in the stability of the gRNA once in the host cell. By combining biophysical, molecular
Externí odkaz:
https://doaj.org/article/314b0e7facb3448facc43c04b309fd42
Autor:
Céline Amadori, Yme Ubeles van der Velden, Damien Bonnard, Igor Orlov, Nikki van Bel, Erwann Le Rouzic, Laia Miralles, Julie Brias, Francis Chevreuil, Daniele Spehner, Sophie Chasset, Benoit Ledoussal, Luzia Mayr, François Moreau, Felipe García, José Gatell, Alessia Zamborlini, Stéphane Emiliani, Marc Ruff, Bruno P. Klaholz, Christiane Moog, Ben Berkhout, Montserrat Plana, Richard Benarous
Publikováno v:
Retrovirology, Vol 14, Iss 1, Pp 1-17 (2017)
Abstract Background HIV-1 Integrase (IN) interacts with the cellular co-factor LEDGF/p75 and tethers the HIV preintegration complex to the host genome enabling integration. Recently a new class of IN inhibitors was described, the IN-LEDGF allosteric
Externí odkaz:
https://doaj.org/article/117a4c221a9c47cda76a3b1cf36e763b
Autor:
Mohamed S. Benleulmi, Julien Matysiak, Xavier Robert, Csaba Miskey, Eric Mauro, Delphine Lapaillerie, Paul Lesbats, Stéphane Chaignepain, Daniel R. Henriquez, Christina Calmels, Oyindamola Oladosu, Eloïse Thierry, Oscar Leon, Marc Lavigne, Marie-Line Andreola, Olivier Delelis, Zoltán Ivics, Marc Ruff, Patrice Gouet, Vincent Parissi
Publikováno v:
Retrovirology, Vol 14, Iss 1, Pp 1-16 (2017)
Abstract Background Stable insertion of the retroviral DNA genome into host chromatin requires the functional association between the intasome (integrase·viral DNA complex) and the nucleosome. The data from the literature suggest that direct protein
Externí odkaz:
https://doaj.org/article/62671881f03f4030ac954009c672ddde
Autor:
Julien Matysiak, Paul Lesbats, Eric Mauro, Delphine Lapaillerie, Jean-William Dupuy, Angelica P. Lopez, Mohamed Salah Benleulmi, Christina Calmels, Marie-Line Andreola, Marc Ruff, Manuel Llano, Olivier Delelis, Marc Lavigne, Vincent Parissi
Publikováno v:
Retrovirology, Vol 14, Iss 1, Pp 1-20 (2017)
Abstract Background Insertion of retroviral genome DNA occurs in the chromatin of the host cell. This step is modulated by chromatin structure as nucleosomes compaction was shown to prevent HIV-1 integration and chromatin remodeling has been reported
Externí odkaz:
https://doaj.org/article/f1a02097fd57468eb90eecfd6d8494e1
Autor:
Erwann Le Rouzic, Damien Bonnard, Frédéric Le Strat, Claire Batisse, Julien Batisse, Céline Amadori, Sophie Chasset, Stéphane Emiliani, Benoit Ledoussal, Marc Ruff, François Moreau, Richard Benarous
LEDGF/p75 (LEDGF) main cellular cofactor of HIV-1 integrase (IN), acts as tethering factor to target integration of HIV in actively transcribed genes. Recently a class of IN inhibitors based on inhibition of LEDGF-IN interaction has been developed. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25c46ee39aebce405fdf8a25d57b6cdf
https://doi.org/10.1101/2023.01.28.523533
https://doi.org/10.1101/2023.01.28.523533
Autor:
Nicolas Levy, Sylvia Eiler, Karine Pradeau-Aubreton, Benoit Maillot, François Stricher, Marc Ruff
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Flexible or disordered domains often hinder the purification of proteins involved in functional interactions. Here the authors describe an approach that enables the production of stable and functional complexes of otherwise unstable proteins in quant
Externí odkaz:
https://doaj.org/article/9ef95dc3bce44f668e21a106a000cf31
Publikováno v:
Cells, Vol 8, Iss 8, p 849 (2019)
HSPA8/HSC70 is a molecular chaperone involved in a wide variety of cellular processes. It plays a crucial role in protein quality control, ensuring the correct folding and re-folding of selected proteins, and controlling the elimination of abnormally
Externí odkaz:
https://doaj.org/article/b6b14acd7a0e4abd855c888367ba45a2
Autor:
Stefano, Ciaco, Krishna, Gavvala, Vanille, Greiner, Viola, Mazzoleni, Pascal, Didier, Marc, Ruff, Lara, Martinez-Fernandez, Roberto, Improta, Yves, Mély
Publikováno v:
Methods and applications in fluorescence. 10(3)
Thienoguanosine (thG) is an isomorphic fluorescent guanosine (G) surrogate, which almost perfectly mimics the natural G in DNA duplexes and may therefore be used to sensitively investigate for example protein-induced local conformational changes. To