Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Marc, Nazaré"'
Autor:
Shixian Yan, Paul Curtis Schöpe, Joe Lewis, Kerstin Putzker, Ulrike Uhrig, Edgar Specker, Jens Peter von Kries, Peter Lindemann, Anahid Omran, Hector E. Sanchez-Ibarra, Anke Unger, Mia-Lisa Zischinsky, Bert Klebl, Wolfgang Walther, Marc Nazaré, Dennis Kobelt, Ulrike Stein
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115698- (2023)
Metastasis is directly linked to poor prognosis of cancer patients and warrants search for effective anti-metastatic drugs. MACC1 is a causal key molecule for metastasis. High MACC1 expression is prognostic for metastasis and poor survival. Here, we
Externí odkaz:
https://doaj.org/article/6858c7b995054e39a758cb5c3e16c24a
Autor:
Jacqueline Langedijk, Erika Ivanna Araya, Amanda Ribeiro Barroso, Dagmar Tolenaars, Marc Nazaré, Hassane Belabed, Jens Schoene, Juliana Geremias Chichorro, Ronald Oude Elferink
Publikováno v:
Frontiers in Pain Research, Vol 3 (2022)
IntroductionThe G-protein coupled receptor LPAR5 plays a prominent role in LPA-mediated pain and itch signaling. In this study we focus on the LPAR5-antagonist compound 3 (cpd3) and its ability to affect pain and itch signaling, both in vitro and in
Externí odkaz:
https://doaj.org/article/b57a9af173bd488d918cfb9ed75bd1f1
Autor:
Lucia Scipioni, Daniel Tortolani, Francesca Ciaramellano, Federico Fanti, Thais Gazzi, Manuel Sergi, Marc Nazaré, Sergio Oddi, Mauro Maccarrone
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6684 (2023)
Dysfunctional phenotype of microglia, the primary brain immune cells, may aggravate Alzheimer’s disease (AD) pathogenesis by releasing proinflammatory factors, such as nitric oxide (NO). The endocannabinoids N-arachidonoylethanolamine (AEA) and 2-a
Externí odkaz:
https://doaj.org/article/0ce4902011074c74bfd0b87d428c79fa
Publikováno v:
CHIMIA, Vol 76, Iss 5 (2022)
Labeled chemical probes are of utmost importance to bring drugs from the laboratory through the clinic and ultimately to market. They support and impact all research and discovery phases: target verification and validation; assay development; lead op
Externí odkaz:
https://doaj.org/article/87148a88a32e4d5494fdf2a1768e93c1
Autor:
Hanna Bonnekoh, Carolina Vera, Angela Abad‐Perez, Silke Radetzki, Martin Neuenschwander, Edgar Specker, Niklas Amadeus Mahnke, Stefan Frischbutter, Eicke Latz, Marc Nazaré, Jens v. Kries, Marcus Maurer, Jörg Scheffel, Karoline Krause
Publikováno v:
Clinical and Translational Allergy, Vol 11, Iss 5, Pp n/a-n/a (2021)
Abstract Background The pathogenesis of contact dermatitis, a common inflammatory skin disease with limited treatment options, is held to be driven by inflammasome activation induced by allergens and irritants. We here aim to identify inflammasome‐
Externí odkaz:
https://doaj.org/article/471c47aa46c6442598d54381170bf9f1
Autor:
María Isabel Fernández-Bachiller, Songhwan Hwang, María Elena Schembri, Peter Lindemann, Mónica Guberman, Svenja Herziger, Edgar Specker, Hans Matter, David W. Will, Jörg Czech, Michael Wagner, Armin Bauer, Herman Schreuder, Kurt Ritter, Matthias Urmann, Volkmar Wehner, Han Sun, Marc Nazaré
Publikováno v:
Journal of Medicinal Chemistry. 65:13013-13028
The accurate prediction of protein-ligand binding affinity belongs to one of the central goals in computer-based drug design. Molecular dynamics (MD)-based free energy calculations have become increasingly popular in this respect due to their accurac
Autor:
Xiao-Lu Li, Tong Ru, Armando Navarro-Vázquez, Peter Lindemann, Marc Nazaré, Xu-Wen Li, Yue-Wei Guo, Han Sun
Publikováno v:
Journal of Natural Products. 85:1730-1737
Natural product dimers have intriguing structural features and often have remarkable pharmacological activities. We report here two uncommon marine gorgonian-derived symmetric dimers, weizhouochrones A (
Autor:
Ludger Starke, Jason M. Millward, Christian Prinz, Fatima Sherazi, Helmar Waiczies, Christoph Lippert, Marc Nazaré, Friedemann Paul, Thoralf Niendorf, Sonia Waiczies
Theranostic imaging methods could greatly enhance our understanding of the distribution of CNS-acting drugs in individual patients. Fluorine-19 magnetic resonance imaging ((19)F MRI) offers the opportunity to localize and quantify fluorinated drugs n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a40af07fd8fa9f77e8f276c63ba9b41
http://edoc.mdc-berlin.de/23050/1/23050oa.pdf
http://edoc.mdc-berlin.de/23050/1/23050oa.pdf
Autor:
Wen-Ting Lo, Hassane Belabed, Murat Kücükdisli, Juliane Metag, Yvette Roske, Polina Prokofeva, Yohei Ohashi, André Horatscheck, Davide Cirillo, Michael Krauss, Christopher Schmied, Martin Neuenschwander, Jens Peter von Kries, Guillaume Médard, Bernhard Kuster, Olga Perisic, Roger L. Williams, Oliver Daumke, Bernard Payrastre, Sonia Severin, Marc Nazaré, Volker Haucke
Phosphatidylinositol 3-kinase type 2α (PI3KC2α) and related class II PI3K isoforms are of increasing biomedical interest because of their crucial roles in endocytic membrane dynamics, cell division and signaling, angiogenesis, and platelet morpholo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e2f007efebfff9a9b182e223cbec7b
http://edoc.mdc-berlin.de/22106/7/22106suppl.zip
http://edoc.mdc-berlin.de/22106/7/22106suppl.zip
Autor:
Marc Nazaré, Uwe Grether
Publikováno v:
Open Access Government. 38:30-31
Visualizing the anti-inflammatory cannabinoid Type-2 receptor Medicinal chemists describe how small molecule probes allow for the detection of CB2R, and thereby enable the discovery of novel anti-inflammatory treatments. The G-protein-coupled recepto