Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Marc, Liesa"'
Autor:
Vincent Gutierrez, Doyeon Kim-Vasquez, Michael Shum, Qihong Yang, Dante Dikeman, Stan G. Louie, Orian S. Shirihai, Hidekazu Tsukamoto, Marc Liesa
Publikováno v:
Redox Biology, Vol 70, Iss , Pp 103052- (2024)
Acute liver failure caused by alcoholic hepatitis (AH) is only effectively treated with liver transplantation. Livers of patients with AH show a unique molecular signature characterized by defective hepatocellular redox metabolism, concurrent to hepa
Externí odkaz:
https://doaj.org/article/f50c083d6e6d4eaebcac3b870c9ad34e
Autor:
Jialiu Zeng, Rebeca Acin-Perez, Essam A. Assali, Andrew Martin, Alexandra J. Brownstein, Anton Petcherski, Lucía Fernández-del-Rio, Ruiqing Xiao, Chih Hung Lo, Michaël Shum, Marc Liesa, Xue Han, Orian S. Shirihai, Mark W. Grinstaff
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. High levels of free fatty acids in the liver impair hepatic lysosomal acidification and reduce autophagic flux. We investigate whether restoration of ly
Externí odkaz:
https://doaj.org/article/7d8571474b5446d88e1e67b698c99e4f
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102408- (2023)
Summary: Assessing the physiological role of H2O2 requires sensitive techniques to quantify H2O2 and antioxidants in live cells. Here, we present a protocol to assess the mitochondrial redox state and unconjugated bilirubin levels in intact live prim
Externí odkaz:
https://doaj.org/article/e588d9c066024a38be8b1851f11cce6a
Autor:
Manuel Albert, Jesús Vázquez, Juan M. Falcón-Pérez, María A. Balboa, Marc Liesa, Jesús Balsinde, Susana Guerra
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT Interferon-stimulated gene 15 (ISG15) is a 15-kDa ubiquitin-like modifier that binds to target proteins in a process termed ISGylation. ISG15, first described as an antiviral molecule against many viruses, participates in numerous cellular p
Externí odkaz:
https://doaj.org/article/c4616c3569d74d538924f381120bf40c
Autor:
Janos Steffen, Jennifer Ngo, Sheng-Ping Wang, Kevin Williams, Henning F. Kramer, George Ho, Carlos Rodriguez, Krishna Yekkala, Chidozie Amuzie, Russell Bialecki, Lisa Norquay, Andrea R. Nawrocki, Mark Erion, Alessandro Pocai, Orian S. Shirihai, Marc Liesa
Publikováno v:
Molecular Metabolism, Vol 64, Iss , Pp 101566- (2022)
Objective: The mitochondrial fission protein Drp1 was proposed to promote NAFLD, as inhibition of hepatocyte Drp1 early in life prevents liver steatosis induced by high-fat diet in mice. However, whether Drp1-knockdown in older mice can reverse estab
Externí odkaz:
https://doaj.org/article/d293ec682a224eca81d3a4cb964a7253
Autor:
Zhi Zhang, Fernando M. C. V. Reis, Yanlin He, Jae W. Park, Johnathon R. DiVittorio, Nilla Sivakumar, J. Edward van Veen, Sandra Maesta-Pereira, Michael Shum, India Nichols, Megan G. Massa, Shawn Anderson, Ketema Paul, Marc Liesa, Olujimi A. Ajijola, Yong Xu, Avishek Adhikari, Stephanie M. Correa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Torpor is a state of reduced metabolism and body temperature that conserves energy when food is scarce. Here the authors show that estrogen-sensitive neurons in the hypothalamus regulate torpor in mice, maintaining torpor in both sexes but initiating
Externí odkaz:
https://doaj.org/article/7b9ecf04f1a846dda1413b72774ce3f8
Autor:
Essam A. Assali, Anthony E. Jones, Michaela Veliova, Rebeca Acín-Pérez, Mahmoud Taha, Nathanael Miller, Michaël Shum, Marcus F. Oliveira, Guy Las, Marc Liesa, Israel Sekler, Orian S. Shirihai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Brown adipose tissue activation of thermogenesis is accompanied by a sequence of events commonly associated with apoptosis, however they evade cell death. Assali et al. show that NCLX prevents mitochondrial calcium overload and apoptosis. Deletion of
Externí odkaz:
https://doaj.org/article/b7d8f16459e24177b94890292b6533d2
Autor:
Michael Shum, Mayuko Segawa, Raffi Gharakhanian, Ana Viñuela, Matthew Wortham, Siyouneh Baghdasarian, Dane M. Wolf, Samuel B. Sereda, Laura Nocito, Linsey Stiles, Zhiqiang Zhou, Vincent Gutierrez, Maike Sander, Orian S. Shirihai, Marc Liesa
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101403- (2022)
Objective: The contribution of beta-cell dysfunction to type 2 diabetes (T2D) is not restricted to insulinopenia in the late stages of the disease. Elevated fasting insulinemia in normoglycemic humans is a major factor predicting the onset of insulin
Externí odkaz:
https://doaj.org/article/9dc2c70f85334be6a42fd766bfb0b160
Autor:
Rebeca Acín-Perez, Anton Petcherski, Michaela Veliova, Ilan Y. Benador, Essam A. Assali, Georgia Colleluori, Saverio Cinti, Alexandra J. Brownstein, Siyouneh Baghdasarian, Masha J. Livhits, Michael W. Yeh, Karthickeyan Chella Krishnan, Laurent Vergnes, Nathan C. Winn, Jaume Padilla, Marc Liesa, Harold S. Sacks, Orian S. Shirihai
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102087- (2021)
Beige adipocyte mitochondria contribute to thermogenesis by uncoupling and by ATP-consuming futile cycles. Since uncoupling may inhibit ATP synthesis, it is expected that expenditure through ATP synthesis is segregated to a disparate population of mi
Externí odkaz:
https://doaj.org/article/4b8e9dfe1be44446bb4a1b85629f27e1
Publikováno v:
Molecular Metabolism, Vol 50, Iss , Pp 101134- (2021)
Background: Mitochondrial oxidative function plays a key role in the development of non-alcoholic fatty liver disease (NAFLD) and insulin resistance (IR). Recent studies reported that fatty liver might not be a result of decreased mitochondrial fat o
Externí odkaz:
https://doaj.org/article/1809f2243fc9453f819fcd059882a14d