Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Marc, Freichel"'
Autor:
Sarah Krukenberg, Franziska Möckl, Mariella Weiß, Patrick Dekiert, Melanie Hofmann, Fynn Gerlach, Kai J. Winterberg, Dejan Kovacevic, Imrankhan Khansahib, Berit Troost, Macarena Hinrichs, Viviana Granato, Mikolaj Nawrocki, Tobis Hub, Volodymyr Tsvilovskyy, Rebekka Medert, Lena-Marie Woelk, Fritz Förster, Huan Li, René Werner, Marcus Altfeld, Samuel Huber, Oliver Biggs Clarke, Marc Freichel, Björn-Philipp Diercks, Chris Meier, Andreas H. Guse
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Upon stimulation of membrane receptors, nicotinic acid adenine dinucleotide phosphate (NAADP) is formed as second messenger within seconds and evokes Ca2+ signaling in many different cell types. Here, to directly stimulate NAADP signaling, M
Externí odkaz:
https://doaj.org/article/fcb6cf2df7404754829e9ef6c09deac4
Autor:
Ulrike Weiss, Eleonora Mungo, Michelle Haß, Denis Benning, Robert Gurke, Lisa Hahnefeld, Erika Dorochow, Jessica Schlaudraff, Tobias Schmid, Silvia Kuntschar, Sofie Meyer, Rebekka Medert, Marc Freichel, Gerd Geisslinger, Ellen Niederberger
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10721 (2024)
The inhibitor-kappaB kinase epsilon (IKKε) represents a non-canonical IκB kinase that modulates NF-κB activity and interferon I responses. Inhibition of this pathway has been linked with atherosclerosis and metabolic dysfunction-associated steatot
Externí odkaz:
https://doaj.org/article/3bb92ad8f76046c9baeff8ad45b0548a
Autor:
Christina Maeder, Thimoteus Speer, Angela Wirth, Jes-Niels Boeckel, Sameen Fatima, Khurrum Shahzad, Marc Freichel, Ulrich Laufs, Susanne Gaul
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe interleukin-1 (IL-1) family and the NLR family pyrin domain-containing 3 (NLRP3) inflammasome contribute to atherogenesis but the underlying mechanisms are incompletely understood. Unlike IL-1β, IL-1α is not dependent on the NLRP3 i
Externí odkaz:
https://doaj.org/article/0e4caefebaa74f0bb994632b3edb5f26
Autor:
Alexander Becker, Stefanie Mannebach, Ilka Mathar, Petra Weissgerber, Marc Freichel, Asia Perveen Loodin, Claudia Fecher-Trost, Anouar Belkacemi, Andreas Beck, Stephan Ernst Philipp
Publikováno v:
Cellular Physiology and Biochemistry, Vol 54, Iss 6, Pp 1115-1131 (2020)
Externí odkaz:
https://doaj.org/article/ee784ceec11543c29fe46d1719b91d69
Autor:
Hagen M. Gegner, Nils Mechtel, Elena Heidenreich, Angela Wirth, Fabiola Garcia Cortizo, Katrin Bennewitz, Thomas Fleming, Carolin Andresen, Marc Freichel, Aurelio A. Teleman, Jens Kroll, Rüdiger Hell, Gernot Poschet
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Metabolic profiling harbors the potential to better understand various disease entities such as cancer, diabetes, Alzheimer’s, Parkinson’s disease or COVID-19. To better understand such diseases and their intricate metabolic pathways in human stu
Externí odkaz:
https://doaj.org/article/1071d247f0c043dca734c40fef308b52
Autor:
Susanne Gaul, Khurrum Shahzad, Rebekka Medert, Ihsan Gadi, Christina Mäder, Dagmar Schumacher, Angela Wirth, Saira Ambreen, Sameen Fatima, Jes-Niels Boeckel, Hamzah Khawaja, Jan Haas, Maik Brune, Peter P. Nawroth, Berend Isermann, Ulrich Laufs, Marc Freichel
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
ObjectiveAtherosclerosis, the main pathology underlying cardiovascular diseases is accelerated in diabetic patients. Genetic mouse models require breeding efforts which are time-consuming and costly. Our aim was to establish a new nongenetic model of
Externí odkaz:
https://doaj.org/article/56c5ef21b0ed4df3b798f8eedcf9f944
Autor:
Oleg Yarishkin, Tam T. T. Phuong, Felix Vazquez-Chona, Jacques Bertrand, Joseph van Battenburg-Sherwood, Sarah N. Redmon, Christopher N. Rudzitis, Monika Lakk, Jackson M. Baumann, Marc Freichel, Eun-Mi Hwang, Darryl Overby, David Križaj
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Trabecular meshwork (TM) cells are phagocytic cells that employ mechanotransduction to actively regulate intraocular pressure. Similar to macrophages, they express scavenger receptors and participate in antigen presentation within the immunosuppressi
Externí odkaz:
https://doaj.org/article/e878d86628904c698824107f4feebaa7
Autor:
Thomas Thumberger, Tinatini Tavhelidse-Suck, Jose Arturo Gutierrez-Triana, Alex Cornean, Rebekka Medert, Bettina Welz, Marc Freichel, Joachim Wittbrodt
Publikováno v:
eLife, Vol 11 (2022)
Precise, targeted genome editing by CRISPR/Cas9 is key for basic research and translational approaches in model and non-model systems. While active in all species tested so far, editing efficiencies still leave room for improvement. The bacterial Cas
Externí odkaz:
https://doaj.org/article/1c7a9b7dea744d699a3a177f618c4dd4
Autor:
Fabiola Garcia Cortizo, Daniel Pfaff, Angela Wirth, Andrea Schlotterer, Rebekka Medert, Jakob Morgenstern, Tobias Weber, Hans-Peter Hammes, Thomas Fleming, Peter Paul Nawroth, Marc Freichel, Aurelio A. Teleman
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101406- (2022)
Objective: Methylglyoxal (MG) is a highly reactive α-oxoaldehyde that glycates proteins. MG has been linked to the development of diabetic complications: MG is the major precursor of advanced glycation end products (AGEs), a risk marker for diabetic
Externí odkaz:
https://doaj.org/article/6586086fec034e6e93d18634639a1dce
Autor:
Aline Schütz, Christin Richter, Petra Weissgerber, Volodymyr Tsvilovskyy, Michael Hesse, Roger Ottenheijm, Frank Zimmermann, Stefanie Buchholz, Rebekka Medert, Sascha Dlugosz, Vladimir Kuryshev, Vladimir Benes, Veit Flockerzi, Bernd K. Fleischmann, Adolfo Cavalié, Marc Freichel
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109851- (2021)
Summary: Early embryogenesis depends on proper control of intracellular homeostasis of ions including Ca2+ and Mg2+. Deletion of the Ca2+ and Mg2+ conducting the TRPM7 channel is embryonically lethal in mice but leaves compaction, blastomere polariza
Externí odkaz:
https://doaj.org/article/11c9f14b7e7c47029d5b6520406b6f06