Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Marc, Flajolet"'
Publikováno v:
ACS Omega, Vol 9, Iss 13, Pp 14771-14780 (2024)
Externí odkaz:
https://doaj.org/article/3d0068bc1c2c4655a026a7a956a01a1e
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107573- (2023)
Summary: High-power screening (HPS) technologies, such as DNA-encoded library (DEL) technology, could exponentially increase the dimensions of the chemical space accessible for drug discovery. The intrinsic fragile nature of DNA is associated with cu
Externí odkaz:
https://doaj.org/article/c856da44681843088a9e7a037d3b4e9f
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Protein kinases play a vital role in biology and deregulation of kinases is implicated in numerous diseases ranging from cancer to neurodegenerative diseases, making them a major target class for the pharmaceutical industry. However, the high degree
Externí odkaz:
https://doaj.org/article/96df9329ac934c1c9b5378a916639675
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
An efficient method for the C-C bond formation via water soluble Na2PdCl4/sSPhos mediated Suzuki-Miyaura cross-coupling reaction of DNA-conjugated aryl iodide with (het)aryl boronic acids has been developed. This reaction proceeds at 37°C in water a
Externí odkaz:
https://doaj.org/article/ae2b244cf16645f7897b576de4c6104c
Autor:
Thomas Liebmann, Nicolas Renier, Karima Bettayeb, Paul Greengard, Marc Tessier-Lavigne, Marc Flajolet
Publikováno v:
Cell Reports, Vol 16, Iss 4, Pp 1138-1152 (2016)
Amyloidosis is a major problem in over one hundred diseases, including Alzheimer’s disease (AD). Using the iDISCO visualization method involving targeted molecular labeling, tissue clearing, and light-sheet microscopy, we studied plaque formation i
Externí odkaz:
https://doaj.org/article/81cb50cfb7834fee86952e0d56ff1f3f
Autor:
Victor Hugo Bustos, Yashoda Krishna Sunkari, Anjana Sinha, Maria Pulina, Ashley Bispo, Maya Hopkins, Alison Lam, Sydney F. Kriegsman, Emily Mui, Emily Chang, Ana Jedlicki, Hannah Rosenthal, Marc Flajolet, Paul Greengard, Subhash C. Sinha
Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder characterized by the accumulation of beta-amyloid (Aβ), C99, and Tau in vulnerable areas of the brain. Despite extensive research, current strategies to lower Aβ levels have sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b996c2596047e1f36028280741db2409
https://doi.org/10.1101/2023.04.28.538773
https://doi.org/10.1101/2023.04.28.538773
Autor:
Enrica Montalban, Albert Giralt, Lieng Taing, Yuki Nakamura, Assunta Pelosi, Mallory Brown, Benoit de Pins, Emmanuel Valjent, Miquel Martin, Angus C. Nairn, Paul Greengard, Marc Flajolet, Denis Hervé, Nicolas Gambardella, Jean-Pierre Roussarie, Jean-Antoine Girault
Publikováno v:
bioRxiv
BACKGROUNDHighly palatable food triggers behavioral alterations reminiscent of those induced by addictive drugs. These effects involve the reward system and dopamine neurons, which modulate neurons in the nucleus accumbens (NAc). The molecular mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b0a4054ca07d7ddb52d40f19f36456
https://doi.org/10.1101/2023.03.07.531496
https://doi.org/10.1101/2023.03.07.531496
Publikováno v:
Chemistry – A European Journal. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07045680f2511277443f3ceb08567b4d
https://doi.org/10.1002/chem.202203037
https://doi.org/10.1002/chem.202203037
Autor:
Patricia Rodriguez-Rodriguez, Luis Enrique Arroyo-Garcia, Lechuan Li, Christina Tsagkogianni, Wei Wang, Isabella Salas-Allende, Zakary Plautz, Angel Cedazo-Minguez, Subhash Sinha, Olga Troyanskaya, Marc Flajolet, Vicky Yao, Jean-Pierre Roussarie
SUMMARYNeurons from layer II of the entorhinal cortex (ECII) are the first to accumulate tau protein aggregates and degenerate during prodromal Alzheimer’s disease. Here, we use a data-driven functional genomics approach to model ECII neuronsin sil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0888f740a9e42fe61780d38536b53083
https://doi.org/10.1101/2022.05.14.491965
https://doi.org/10.1101/2022.05.14.491965
Publikováno v:
Communicative & Integrative Biology, Vol 3, Iss 6, Pp 487-490 (2010)
Norbin, a neurite-outgrowth promoting protein, has been found to interact with and regulate several membrane proteins, including metabotropic glutamate receptor 5 (mGluR5). The disruption of both Norbin alleles leads to early embryonic death between
Externí odkaz:
https://doaj.org/article/d7784a97fd3f4928ae7f9b82dc0d6b22