Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Marc, Fahrner"'
Autor:
Lena Maltan, Sarah Weiß, Hadil Najjar, Melanie Leopold, Sonja Lindinger, Carmen Höglinger, Lorenz Höbarth, Matthias Sallinger, Herwig Grabmayr, Sascha Berlansky, Denis Krivic, Valentina Hopl, Anna Blaimschein, Marc Fahrner, Irene Frischauf, Adéla Tiffner, Isabella Derler
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
The Ca2+ ion channel Orai1 is crucial in immune cells. Here, the authors applied genetic code expansion to transfer light-sensitivity to the Orai1 channel and achieved precise control over its function.
Externí odkaz:
https://doaj.org/article/bee2dd102ac04d1e8838711cbc3c5162
Autor:
Marc Fahrner, Christoph Romanin
Publikováno v:
eLife, Vol 10 (2021)
Harnessing single-molecule FRET illuminates the structural changes necessary for a protein to fine-tune the influx of calcium when reserves inside a cell run low.
Externí odkaz:
https://doaj.org/article/07e83ab1d5d8445b91c194a677a4f65b
Autor:
Christina Humer, Sascha Berlansky, Herwig Grabmayr, Matthias Sallinger, Andreas Bernhard, Marc Fahrner, Irene Frischauf
Publikováno v:
Cells, Vol 11, Iss 11, p 1849 (2022)
All human life starts with a calcium (Ca2+) wave. This ion regulates a plethora of cellular functions ranging from fertilisation and birth to development and cell death. A sophisticated system is responsible for maintaining the essential, tight conce
Externí odkaz:
https://doaj.org/article/7b9a58a4060b4721b2b301708a5df281
Autor:
Adéla Tiffner, Lena Maltan, Marc Fahrner, Matthias Sallinger, Sarah Weiß, Herwig Grabmayr, Carmen Höglinger, Isabella Derler
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
STIM1-mediated activation of calcium selective Orai channels is fundamental for life. The three Orai channel isoforms, Orai1-3, together with their multiple ways of interplay, ensure their highly versatile role in a variety of cellular functions and
Externí odkaz:
https://doaj.org/article/32d3b31dd9ba4d7482c14a4837ec3a62
Autor:
Christine Silvia Gibhardt, Sabrina Cappello, Rajesh Bhardwaj, Romana Schober, Sonja Agnes Kirsch, Zuriñe Bonilla del Rio, Stefan Gahbauer, Anna Bochicchio, Magdalena Sumanska, Christian Ickes, Ioana Stejerean-Todoran, Miso Mitkovski, Dalia Alansary, Xin Zhang, Aram Revazian, Marc Fahrner, Victoria Lunz, Irene Frischauf, Ting Luo, Daria Ezerina, Joris Messens, Vsevolod Vadimovich Belousov, Markus Hoth, Rainer Arnold Böckmann, Matthias Albrecht Hediger, Rainer Schindl, Ivan Bogeski
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108292- (2020)
Summary: Store-operated calcium entry (SOCE) through STIM-gated ORAI channels governs vital cellular functions. In this context, SOCE controls cellular redox signaling and is itself regulated by redox modifications. However, the molecular mechanisms
Externí odkaz:
https://doaj.org/article/9aa210ab347a4829a53ce714c6a1e9f1
Autor:
Sascha Berlansky, Matthias Sallinger, Herwig Grabmayr, Christina Humer, Andreas Bernhard, Marc Fahrner, Irene Frischauf
Publikováno v:
Cells, Vol 11, Iss 2, p 253 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). This respiratory illness was declared a pandemic by the world health organization (WHO) in Mar
Externí odkaz:
https://doaj.org/article/9cb5b9e2caf74f139eef58007c82bbc5
Autor:
Marc Fahrner, Michael Stadlbauer, Martin Muik, Petr Rathner, Peter Stathopulos, Mitsu Ikura, Norbert Müller, Christoph Romanin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Stormorken syndrome is associated with the R304W mutation in STIM1, which is a Calcium sensor in the endoplasmic reticulum. Here authors use FRET and electrophysiology to show that R304W induces STIM1 conformational extension by a dual mechanism resu
Externí odkaz:
https://doaj.org/article/f3d205c02ef7403b8fda99785e3df276
Autor:
Adéla Tiffner, Valentina Hopl, Romana Schober, Matthias Sallinger, Herwig Grabmayr, Carmen Höglinger, Marc Fahrner, Victoria Lunz, Lena Maltan, Irene Frischauf, Denis Krivic, Rajesh Bhardwaj, Rainer Schindl, Matthias A. Hediger, Isabella Derler
Publikováno v:
Cancers, Vol 13, Iss 24, p 6357 (2021)
The interplay of SK3, a Ca2+ sensitive K+ ion channel, with Orai1, a Ca2+ ion channel, has been reported to increase cytosolic Ca2+ levels, thereby triggering proliferation of breast and colon cancer cells, although a molecular mechanism has remained
Externí odkaz:
https://doaj.org/article/66683336ac42453dbca136ac9d665771
Autor:
Ferdinand Horvath, Sascha Berlansky, Lena Maltan, Herwig Grabmayr, Marc Fahrner, Isabella Derler, Christoph Romanin, Thomas Renger, Heinrich Krobath
Publikováno v:
Protein Science. 32
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 378 (2020)
Stromal interaction molecules (STIM) are a distinct class of ubiquitously expressed single-pass transmembrane proteins in the endoplasmic reticulum (ER) membrane. Together with Orai ion channels in the plasma membrane (PM), they form the molecular ba
Externí odkaz:
https://doaj.org/article/dfde9a8357d347838ee3c8ecb253b932