Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Marc, Delarue"'
Autor:
Leonardo Betancurt-Anzola, Markel Martínez-Carranza, Marc Delarue, Kelly M. Zatopek, Andrew F. Gardner, Ludovic Sauguet
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Replicative DNA polymerases duplicate entire genomes at high fidelity. This feature is shared among the three domains of life and is facilitated by their dual polymerase and exonuclease activities. Family D replicative DNA polymerases (PolD)
Externí odkaz:
https://doaj.org/article/6fa735390f164ee1a07c249234ceecde
Autor:
Clément Madru, Markel Martínez-Carranza, Sébastien Laurent, Alessandra C. Alberti, Maelenn Chevreuil, Bertrand Raynal, Ahmed Haouz, Rémy A. Le Meur, Marc Delarue, Ghislaine Henneke, Didier Flament, Mart Krupovic, Pierre Legrand, Ludovic Sauguet
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Replication Protein A (RPA) is a heterotrimeric single stranded DNA-binding protein with essential roles in DNA replication, recombination and repair. Little is known about the structure of RPA in Archaea, the third domain of life. By using
Externí odkaz:
https://doaj.org/article/8ae48732a3044f69b9e87147a45794c9
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The cyanophage S-2L incorporates 2-aminoadenine (Z) instead of adenine into its DNA, which still pairs with thymine forming a triple hydrogen bond. Here, the authors identify a third gene mazZ located between purZ and datZ that is required for 2-amin
Externí odkaz:
https://doaj.org/article/2c5f8be15bf64c02b05de1d016baf972
Publikováno v:
Viruses, Vol 15, Iss 6, p 1366 (2023)
The current SARS-CoV-2 pandemic highlights our fragility when we are exposed to emergent viruses either directly or through zoonotic diseases. Fortunately, our knowledge of the biology of those viruses is improving. In particular, we have more and mo
Externí odkaz:
https://doaj.org/article/0f683c51a2ac4240afe5f442faadb01a
Autor:
Dariusz Czernecki, Pierre Legrand, Mustafa Tekpinar, Sandrine Rosario, Pierre-Alexandre Kaminski, Marc Delarue
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The cyanophage S-2L incorporates 2-aminoadenine (Z) instead of adenine (A) in its genome. Here, the authors provide an explanation for the absence of A in S-2L genome by identifying and characterising functionally and structurally both the HD phospho
Externí odkaz:
https://doaj.org/article/abe6a0fc434445db8149e9dae08610a3
Publikováno v:
Algorithms, Vol 16, Iss 3, p 131 (2023)
The Gromov-Wasserstein (GW) formalism can be seen as a generalization of the optimal transport (OT) formalism for comparing two distributions associated with different metric spaces. It is a quadratic optimization problem and solving it usually has c
Externí odkaz:
https://doaj.org/article/e56ddd45039b48349f11a06a7d9d1152
Autor:
Clément Madru, Ghislaine Henneke, Pierre Raia, Inès Hugonneau-Beaufet, Gérard Pehau-Arnaudet, Patrick England, Erik Lindahl, Marc Delarue, Marta Carroni, Ludovic Sauguet
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Replicative DNA polymerases (DNAPs) have evolved the ability to copy the genome with high processivity and fidelity. Here, the authors present a cryo-EM structure of the DNA-bound PolD–PCNA complex from Pyrococcus abyssi to reveal the molecular bas
Externí odkaz:
https://doaj.org/article/d0e3b6dc33ce4f07adff0554f5e474a0
Autor:
Clément Madru, Ayten Dizkirici Tekpinar, Sandrine Rosario, Dariusz Czernecki, Sébastien Brûlé, Ludovic Sauguet, Marc Delarue
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250610 (2021)
To stop the COVID-19 pandemic due to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which caused more than 2.5 million deaths to date, new antiviral molecules are urgently needed. The replication of SARS-CoV-2 requires the RNA-depe
Externí odkaz:
https://doaj.org/article/420e08afabc54742ac1f3b295bdff275
Autor:
Zaineb Fourati, Rebecca J. Howard, Stephanie A. Heusser, Haidai Hu, Reinis R. Ruza, Ludovic Sauguet, Erik Lindahl, Marc Delarue
Publikováno v:
Cell Reports, Vol 23, Iss 4, Pp 993-1004 (2018)
Summary: Ion channel modulation by general anesthetics is a vital pharmacological process with implications for receptor biophysics and drug development. Functional studies have implicated conserved sites of both potentiation and inhibition in pentam
Externí odkaz:
https://doaj.org/article/bdbb904308384d8ba7ddb81e8effab34
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 2023, 51 (9), pp.4488-4507. ⟨10.1093/nar/gkad242⟩
Nucleic Acids Research, 2023, 51 (9), pp.4488-4507. ⟨10.1093/nar/gkad242⟩
Family A DNA polymerases (PolAs) form an important and well-studied class of extant polymerases participating in DNA replication and repair. Nonetheless, despite the characterization of multiple subfamilies in independent, dedicated works, their comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5def6b89d0911d738971d52ee174e69a
https://hal-pasteur.archives-ouvertes.fr/pasteur-04112612/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-04112612/document