Zobrazeno 1 - 10
of 305
pro vyhledávání: '"Marc, Bissonnette"'
Autor:
Xiao-Long Cui, Ji Nie, Houxiang Zhu, Krissana Kowitwanich, Alana V. Beadell, Diana C. West-Szymanski, Zhou Zhang, Urszula Dougherty, Akushika Kwesi, Zifeng Deng, Yan Li, Danqing Meng, Kevin Roggin, Teresa Barry, Ryan Owyang, Ben Fefferman, Chang Zeng, Lu Gao, Carolyn W. T. Zhao, Yuri Malina, Jiangbo Wei, Melanie Weigert, Wenjun Kang, Ajay Goel, Brian C.-H. Chiu, Marc Bissonnette, Wei Zhang, Mengjie Chen, Chuan He
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Methylation-based liquid biopsies show promises in detecting cancer using circulating cell-free DNA; however, current limitations impede clinical application. Most assays necessitate substantial DNA inputs, posing challenges. Additionally, u
Externí odkaz:
https://doaj.org/article/5bb50822efdf457baaf29b14934cc113
Autor:
Lu Gao, Zhou Zhang, Xiao-Long Cui, Diana West-Szymanski, Chang Ye, Chuan He, Wei Zhang, Marc Bissonnette
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
ABSTRACTBackground: Elucidating epigenetic mechanisms could provide new biomarkers for disease diagnosis and prognosis. Technological advances allow genome-wide profiling of 5-hydroxymethylcytosines (5hmC) in liquid biopsies. 5hmC-Seal followed by NG
Externí odkaz:
https://doaj.org/article/0976d9c24d404580be02b96f64fabf41
Autor:
Alexei J. Stuckel, Shuai Zeng, Zhen Lyu, Wei Zhang, Xu Zhang, Urszula Dougherty, Reba Mustafi, Tripti Khare, Qiong Zhang, Trupti Joshi, Marc Bissonnette, Sharad Khare
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
Sprouty4 (SPRY4) has been frequently reported as a tumor suppressor and is therefore downregulated in various cancers. For the first time, we report that SPRY4 is epigenetically upregulated in colorectal cancer (CRC). In this study, we explored DNA m
Externí odkaz:
https://doaj.org/article/01f8717e29a94b0eaa5128dbd992adb5
Publikováno v:
Epigenetics, Vol 17, Iss 13, Pp 2318-2331 (2022)
CXCR4 is involved in many facets of cancer, including being a major player in establishing metastasis. This is in part due to the deregulation of CXCR4, which can be attributed to many genetic and epigenetic mechanisms, including aberrant microRNA–
Externí odkaz:
https://doaj.org/article/ee2dbae64af94adf8ad00e06d8e14eb6
Autor:
Muhammad G. Kibriya, Farzana Jasmine, Yuliia Khamkevych, Maruf Raza, Mohammed Kamal, Marc Bissonnette, Habibul Ahsan
Publikováno v:
Medicina, Vol 60, Iss 3, p 348 (2024)
Background and Objective: In sporadic colorectal carcinomas (CRC), microsatellite instability (MSI) pathways play important roles. Previously, we showed differences in DNA methylation patterns in microsatellite stable (MSS) colorectal carcinomas and
Externí odkaz:
https://doaj.org/article/f0301a9271d74a91a66e7efc82d180a3
Autor:
Urszula Dougherty, Reba Mustafi, Hongyan Zhu, Xiaorong Zhu, Dilip Deb, Stephen C. Meredith, Fatma Ayaloglu-Butun, Michelle Fletcher, Arantxa Sanchez, Joel Pekow, Zifeng Deng, Nader Amini, Vani J Konda, Vijaya L. Rao, Atsushi Sakuraba, Akushika Kwesi, Sonia S Kupfer, Alessandro Fichera, Loren Joseph, John Hart, Fang He, Tong-Chuan He, Diana West-Szymanski, Yan Chun Li, Marc Bissonnette
Publikováno v:
Epigenetics, Vol 16, Iss 12, Pp 1317-1334 (2021)
Because ADAM17 promotes colonic tumorigenesis, we investigated potential miRNAs regulating ADAM17; and examined effects of diet and tumorigenesis on these miRNAs. We also examined pre-miRNA processing and tumour suppressor roles of several of these m
Externí odkaz:
https://doaj.org/article/acd55d7ef57b4fb5860f8bbd146ae130
Autor:
Tijana Rajh, Tamara Koritarov, Ben Blaiszik, Syeda Fatima Z. Rizvi, Vani Konda, Marc Bissonnette
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Bioinspired photocatalysis has resulted in efficient solutions for many areas of science and technology spanning from solar cells to medicine. Here we show a new bioinspired semiconductor nanocomposite (nanoTiO2-DOPA-luciferase, TiDoL) capable of con
Externí odkaz:
https://doaj.org/article/b7ed2f2ef0b74aa187f6aad3b6565d31
Autor:
Xiaomin Jiang, Wenbo Han, Jianqiao Liu, Jianming Mao, Morten J. Lee, Megan Rodriguez, Youyou Li, Taokun Luo, Ziwan Xu, Kaiting Yang, Marc Bissonnette, Ralph R. Weichselbaum, Wenbin Lin
Publikováno v:
Advanced Science, Vol 9, Iss 24, Pp n/a-n/a (2022)
Abstract The binding of plasma proteins to nanomedicines is widely considered detrimental to their delivery to tumors. Here, the design of OxPt/SN38 nanoparticle containing a hydrophilic oxaliplatin (OxPt) prodrug in a coordination polymer core and a
Externí odkaz:
https://doaj.org/article/50066efeaa414d2cb1308b46e06314f1
Autor:
Xiao-Long Cui, Ji Nie, Jeremy Ku, Urszula Dougherty, Diana C. West-Szymanski, Francois Collin, Christopher K. Ellison, Laura Sieh, Yuhong Ning, Zifeng Deng, Carolyn W. T. Zhao, Anna Bergamaschi, Joel Pekow, Jiangbo Wei, Alana V. Beadell, Zhou Zhang, Geeta Sharma, Raman Talwar, Patrick Arensdorf, Jason Karpus, Ajay Goel, Marc Bissonnette, Wei Zhang, Samuel Levy, Chuan He
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
DNA 5-hydroxymethylcytosine (5hmC) modification is associated with gene transcription and used as a mark of mammalian development. Here the authors report a comprehensive 5hmC tissue map and analysis of 5hmC genomic distributions in 19 human tissues
Externí odkaz:
https://doaj.org/article/422a834f9ee54a78aa65900aafeb0d8b
Autor:
Jeffrey S. Souris, Lara Leoni, Hannah J. Zhang, Ariel Pan, Eve Tanios, Hsiu-Ming Tsai, Irina V. Balyasnikova, Marc Bissonnette, Chin-Tu Chen
Publikováno v:
Nanomaterials, Vol 13, Iss 4, p 673 (2023)
Photodynamic therapy (PDT), the use of light to excite photosensitive molecules whose electronic relaxation drives the production of highly cytotoxic reactive oxygen species (ROS), has proven an effective means of oncotherapy. However, its applicatio
Externí odkaz:
https://doaj.org/article/a72c74d1fa3a445982e75c854b77d986