A new triphenylphosphonium-conjugated amphipathic cationic peptide with improved cell-penetrating and ROS-targeting properties

Autor: Rezeda A. Ishkaeva, Diana V. Salakhieva, Ruslan Garifullin, Raghad Alshadidi, Alexander V. Laikov, Abdulla A. Yergeshov, Marat I. Kamalov, Timur I. Abdullin

Publikováno v: Current Research in Pharmacology and Drug Discovery, Vol 4, Iss , Pp 100148- (2023)

We study for the first time whether triphenylphosphonium (TPP) moiety can improve cellular delivery and redox properties of amphipathic cationic peptides based on YRFK/YrFK cell-penetrating and cytoprotective motif. TPP moiety was found to increase r

Externí odkaz: https://doaj.org/article/5811afde72d640808a5b23cee016092a

Triphenylphosphonium Moiety Modulates Proteolytic Stability and Potentiates Neuroprotective Activity of Antioxidant Tetrapeptides in Vitro

Autor: Rezeda A. Akhmadishina, Ruslan Garifullin, Natalia V. Petrova, Marat I. Kamalov, Timur I. Abdullin

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Although delocalized lipophilic cations have been identified as effective cellular and mitochondrial carriers for a range of natural and synthetic drug molecules, little is known about their effects on pharmacological properties of peptides. The effe

Externí odkaz: https://doaj.org/article/39a62a04fd8d4fe1ad995f08d969a2fa

List of contributors

Autor: Ana Beatriz Afonso, Robson Amaral, Luciana N. Andrade, Heloisa Balan Assalin, Reinaldo Gaspar Bastos, Catherine Baugé, Sarwar Beg, Gabriel Gaspar Bíscaro, S. Bonde, Lorena Bonilla-Vidal, P. Boonme, Karim Boumediene, Carolina Caliari-Oliveira, Amanda Cano, Raffaele Capasso, Claudia Carbone, Juliana C. Cardoso (J.C. Cardoso), Marco Vinicius Chaud (Marco V. Chaud), Beatriz Clares, Maria C. Costa, Tiago E. Coutinho, Ana T. Cruz, Classius F. da Silva, Ricardo L.C. de Albuquerque-Júnior, Luciana M. de Hollanda, Bruna Alice G. de Melo (B.A.G. de Melo), Alexandre Leite Rodrigues de Oliveira, Alexandro Barbosa de Souza, J. Dias-Ferreira, Andrey dos Santos, Nelson Durán, Alessandra Durazzo, Piotr Eder, Marta Espina, Gerard Esteruelas, Wagner J. Fávaro, Fabio Rocha Formiga, Inês Formoso, Carla G. França, Patricia Gálvez, María Luisa García, María T. Garrido, Mira Hammad, Mayank Handa, Stephany C. Huber, J. Jovanovic, Marat I. Kamalov, Anðelka Kovačevi, José Fabio S.D. Lana, Krissia Caroline Leme, Daniele M. Lima, Massimo Lucarini, Ângela Cristina Malheiros Luzo (Ângela Cristina M. Luzo), Adriana Oliveira Manfiolli, Patrick Masson, Luis Fernando Mercier Franco, Kailas Kalicharan Moravkar, Joana Nobre, Chandrakantsing Vijaysing Pardeshi, Tatiana N. Pashirova, M. Patel, R. Patel, Jaywant Pawar, Pedro de Alcântara Pessoa Filho, M. Rai, Manuel Ríos, Elena Sánchez López, Elena López, Maria Helena A. Santana (Maria H. Santana), Antonello Santini, Patrícia Severino (P. Severino), Ranjita Shegokar, Andrea A.M. Shimojo, Dilip Waman Shingare, Rahul Shukla, Amélia M. Silva, K.K. Singh, Mukesh Soni, José L. Soriano, Eliana B. Souto, Claudia Herrera Tambeli, M.C. Teixeira, Natalia V. Terekhova, Aleksandra Zielinska (A. Zielińska)

Publikováno v: Nanotechnology and Regenerative Medicine ISBN: 9780323904711

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::572ddcd232bc1cc3089d6091ffbba4f4
https://doi.org/10.1016/b978-0-323-90471-1.00027-x

Cell-Modulating Effect of Poly(Aspartic Acid) and Its Complex with Cationic Polyaspartamide

Autor: Marat I Kamalov, Timur I. Abdullin, Diana V. Salakhieva, A. M. Pavlyuk, Andrey V. Nemtarev

Publikováno v: BioNanoScience. 10:625-632

In this communication, poly(aspartic acid) (pAsp), its fluorescently labeled conjugate with lucifer yellow ethylenediamine (pAsp–LY), and 2,2-dimethyl-1,3-propanediamine-derived cationic polyaspartamide (pDmpa) were synthesized by liquid-phase meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae4d338ec24dce96b758443cd93676bb
https://doi.org/10.1007/s12668-020-00744-y

Comparison of systemic and localized carrier-mediated delivery of methylprednisolone succinate for treatment of acute spinal cord injury

Autor: Maxim E, Baltin, Diana E, Sabirova, Elvira I, Kiseleva, Marat I, Kamalov, Timur I, Abdullin, Natalia V, Petrova, Nafis F, Ahmetov, Oscar A, Sachenkov, Tatiana V, Baltina, Igor A, Lavrov

Publikováno v: Experimental brain research. 239(2)

Localized carrier-mediated administration of drugs is a promising approach to treatment of acute phase of spinal cord injury (SCI) as it allows enhanced and/or sustained drug delivery to damaged tissues along with minimization of systemic side effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2446bec1e94cac1fb85c149fbaa76b6
https://pubmed.ncbi.nlm.nih.gov/33388811