Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Marat Alimzhanov"'
Autor:
Jacques Moisan, Chunxiao Xu, Amit Deshpande, Joern-Peter Halle, Neil Brewis, Lindsay Webb, Brain Rabinovich, Xueyuan Zhou, Frederic Christian Pipp, Rene Schweickhardt, Sireesha Yalavarthi, Clotilde Bourin, Payel Ghatak, Barroq Safi, Francisca Wollerton, Jose Munoz-Olaya, Natalya Belousova, Marat Alimzhanov, Martina Hubensack, Andree Blaukat
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/ac03000f810b45d7aff318ced96b4000
Autor:
Amit Deshpande, Barroq Safi, Martina Hubensack, Lindsay Webb, Rene Schweickhardt, Natalya Belousova, Payel Ghatak, Francisca Wollerton, Joern-Peter Halle, Marat Alimzhanov, Frederic Christian Pipp, Jacques Moisan, Brain Rabinovich, Neil Brewis, Xueyuan Zhou, Andree Blaukat, Chunxiao Xu, Jose Munoz-Olaya, Clotilde Bourin, Sireesha Yalavarthi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundThe costimulatory receptor CD137 (also known as 4-1BB and TNFRSF9) plays an important role in sustaining effective cytotoxic T cell immune responses and its agonism has been investigated as a cancer immunotherapy. In clinical trials, the sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73aa234bc3dcbc6a5231d8e56b5ec32b
https://doaj.org/article/ac03000f810b45d7aff318ced96b4000
https://doaj.org/article/ac03000f810b45d7aff318ced96b4000
Autor:
Haixia Wang, Marat Alimzhanov, Paul Lyne, Jason Grant Kettle, Jie Shi, Aarti Kawatkar, Linette Ruston, Geraldine Bebernitz, Richard Woessner, Dennis Huszar, Melissa Vasbinder, Michael Zinda, Weijia Zheng, Andrew D. Ferguson, Thomas Gero, Scott Throner, Patricia Schroeder, Kirsten Bell, Minwei Ye, Neil P. Grimster, Allan Wu, Caroline Rivard Costa, Qibin Su, Dorin Toader, Claudio Chuaqui, Jon Read, Andreas Harsch, Tracy L. Deegan, Erica Anderson
Publikováno v:
Journal of Medicinal Chemistry. 61:5235-5244
Janus kinases (JAKs) have been demonstrated to be critical in cytokine signaling and have thus been implicated in both cancer and inflammatory diseases. The JAK family consists of four highly homologous members: JAK1-3 and TYK2. The development of sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8f93ed398355884d7771aa4e28e3aa
https://doi.org/10.1021/acs.jmedchem.8b00076
https://doi.org/10.1021/acs.jmedchem.8b00076
Autor:
Emma Jenkins, Larry Bao, Christopher R. Denz, Andrew D. Ferguson, Geoff Holdgate, Marat Alimzhanov, Timothy Pontz, Nicholas A. Larsen, Paul Lyne, Claudio Chuaqui, Nichole O'Connell, James E. Dowling, Qing Ye, Lindsay Snow
Publikováno v:
ACS Medicinal Chemistry Letters. 7:300-305
The Wnt pathway is an evolutionarily conserved and tightly regulated signaling network with important roles in embryonic development and adult tissue regeneration. Impaired Wnt pathway regulation, arising from mutations in Wnt signaling components, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0081f51b8216eb78dbcb860f4495d721
https://doi.org/10.1021/acsmedchemlett.5b00452
https://doi.org/10.1021/acsmedchemlett.5b00452
Autor:
Jon Read, Haixia Wang, Dennis Huszar, Sameer Kawatkar, Kelly Goodwin, Martin Augustin, Stefan Steinbacher, Melissa Vasbinder, Andrew D. Ferguson, Qibin Su, Allan Wu, Tracy L. Deegan, Holger Steuber, Geraldine Bebernitz, Dorin Toader, Claudio Chuaqui, Kirsten Bell, Michael Zinda, Jie Shi, Minwei Ye, Marat Alimzhanov, Richard Woessner, Aarti Kawatkar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:60-67
We have identified a class of azabenzimidazoles as potent and selective JAK1 inhibitors. Investigations into the SAR are presented along with the structural features required to achieve selectivity for JAK1 versus other JAK family members. An example
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2032e7ccbbb67ca646276f7a6e7cd07
https://doi.org/10.1016/j.bmcl.2015.11.031
https://doi.org/10.1016/j.bmcl.2015.11.031
Autor:
Andree Blaukat, Marat Alimzhanov, Frank Zenke, Christiane Amendt, Patricia Soulard, Ashwin George, Joern-Peter Halle, Astrid Zimmerman, Parantu K. Shah, Andreas Schroeder, Martin H. Falk
Publikováno v:
Cancer Research. 80:964-964
Ataxia-telangiectasia mutated and Rad3-related kinase (ATR) is one of the key players in the DNA damage response (DDR) to replication stress. M6620 is a potent and selective ATR inhibitor which has been shown to sensitize cancer cells to the lethal e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7af4b48d8d643d40124cd69d316333ba
https://doi.org/10.1158/1538-7445.am2020-964
https://doi.org/10.1158/1538-7445.am2020-964
Autor:
Marat Alimzhanov, Patricia Soulard, Astrid Zimmermann, Andreas Schroeder, Keyvan Tadjalli Mehr, Christiane Amendt, Geok Choo Sim, Andree Blaukat, Joern-Peter Halle, Frank T. Zenke
Publikováno v:
Cancer Research. 79:2269-2269
Recently, combination of checkpoint inhibitors with chemotherapy demonstrated significant improvement of overall survival (OS) and progression-free survival (PFS) compared with chemotherapy alone in patients with metastatic non-squamous and squamous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14a6d6b46bdc17d2ea07c237eebf88ff
https://doi.org/10.1158/1538-7445.am2019-2269
https://doi.org/10.1158/1538-7445.am2019-2269
Autor:
Tina Howard, Jie Shi, Kirsten Bell, Jon Read, Dennis Huszar, Marat Alimzhanov, Claudio Chuaqui, Lynsie Almeida, Geraldine Bebernitz, Michael Zinda, Shan Huang, Qibin Su, Stephanos Ioannidis, Mei Su, Michael Howard Block, Minwei Ye, Caroline Rivard Costa
Publikováno v:
Journal of Medicinal Chemistry. 57:144-158
Structure based design, synthesis, and biological evaluation of a novel series of 1-methyl-1H-imidazole, as potent Jak2 inhibitors to modulate the Jak/STAT pathway, are described. Using the C-ring fragment from our first clinical candidate AZD1480 (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab13e0e0cd5b5d00f867f1419e01319
https://doi.org/10.1021/jm401546n
https://doi.org/10.1021/jm401546n
Autor:
Larry Bao, Jamal Carlos Saeh, Emma L. Cooke, Christopher R. Denz, Claudio Chuaqui, Bo Peng, James E. Dowling, Qing Ye, Caroline Rivard-Costa, Michael Howard Block, Marat Alimzhanov, Paul Lyne, Timothy Pontz, Shan Huang, Kumar Thakur, Alexander Hird, Nicholas A. Larsen, Tao Zhang
Publikováno v:
ACS Medicinal Chemistry Letters. 4:800-805
In this letter, we describe the design, synthesis, and structure-activity relationship of 5-anilinopyrazolo[1,5-a]pyrimidine inhibitors of CK2 kinase. Property-based optimization of early leads using the 7-oxetan-3-yl amino group led to a series of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91328c92e5f5b40f52e7ed4fcf60cf33
https://doi.org/10.1021/ml400197u
https://doi.org/10.1021/ml400197u
Autor:
Jiaquan Wu, Jon Read, Shan Huang, Geraldine Bebernitz, Michael Zinda, Syeed Hussain, Marat Alimzhanov, Kirsten Bell, Nancy DeGrace, Michelle Lamb, Guan Huiping, Caroline Rivard, Stephanos Ioannidis, Minwei Ye, Bo Peng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3105-3110
The discovery of the activating mutation V617F in the JH2 domain of Jak2 and the modulation of oncogenic Stat3 by Jak2 inhibitors have spurred a great interest in the inhibition of the Jak2/Stat pathway in oncology. In this Letter, we communicate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6a2791a8a3f7af3ef48c74521912bf
https://doi.org/10.1016/j.bmcl.2013.02.111
https://doi.org/10.1016/j.bmcl.2013.02.111