Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Marat, Yusupov"'
Autor:
Alexander Golubev, Luc Negroni, Filipp Krasnovid, Shamil Validov, Gulnara Yusupova, Marat Yusupov, Konstantin Usachev
Publikováno v:
FEBS Open Bio, Vol 10, Iss 7, Pp 1342-1347 (2020)
Antibiotic‐resistant Staphylococcus aureus is becoming a major burden on health care systems in many countries, necessitating the identification of new targets for antibiotic development. Elongation Factor P (EF‐P) is a highly conserved elongatio
Externí odkaz:
https://doaj.org/article/97e37172150348cf879427859a337414
Autor:
Iskander Khusainov, Bulat Fatkhullin, Simone Pellegrino, Aydar Bikmullin, Wen-ti Liu, Azat Gabdulkhakov, Amr Al Shebel, Alexander Golubev, Denis Zeyer, Natalie Trachtmann, Georg A. Sprenger, Shamil Validov, Konstantin Usachev, Gulnara Yusupova, Marat Yusupov
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Upon transition to stationary phase or upon stress, bacteria limit protein synthesis through small inhibitory proteins that bind the ribosome. Here the authors decipher the interaction mode of the bacterial ribosome silencing factor (RsfS) at atomic
Externí odkaz:
https://doaj.org/article/1ad738db839640ba9241f8a79ce45330
Autor:
Margarita Belinite, Iskander Khusainov, Heddy Soufari, Stefano Marzi, Pascale Romby, Marat Yusupov, Yaser Hashem
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Cryo-electron microscopy is now used as a method of choice in structural biology for studying protein synthesis, a process mediated by the ribosome machinery. In order to achieve high-resolution structures using this approach, one needs to obtain hom
Externí odkaz:
https://doaj.org/article/23d21fc50ef041a88dc7a44daa03a6f9
Autor:
Alexey Rozov, Iskander Khusainov, Kamel El Omari, Ramona Duman, Vitaliy Mykhaylyk, Marat Yusupov, Eric Westhof, Armin Wagner, Gulnara Yusupova
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Metal ions play essential roles in myriads of biological processes, from catalytic co-factors to supporting protein and nucleic acid structures. Here the authors use long-wavelength X-ray diffraction to locate hundreds of potassium ions taking part i
Externí odkaz:
https://doaj.org/article/9be87daf909449729d1006985b3020d8
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
During stress conditions bacterial ribosomes dimerize and form inactive but stable hibernating 100S particles, a process that is facilitated by the hibernation-promoting factor (HPF). Here the authors analyze 100S dimer formation as a function of HPF
Externí odkaz:
https://doaj.org/article/5cc48ee25d5f4ef09112efa40bc3bd60
Autor:
Alexander Golubev, Bulat Fatkhullin, Iskander Khusainov, Shamil Validov, Marat Yusupov, Konstantin Usachev
Publikováno v:
International Journal of Biomedicine, Vol 11, Iss Suppl_1, Pp 22-23 (2021)
Background: Antibiotic resistance is a growing worldwide problem. One of the major resistant bacterial pathogens is Staphylococcus aureus, which became a burden of healthcare systems around the world. To overcome the issue, more drug discovery studie
Externí odkaz:
https://doaj.org/article/f9d073d4a59f48179945523b8ee4f99a
Publikováno v:
International Journal of Biomedicine, Vol 9, Iss Suppl_1, Pp S11-S12 (2019)
Background: In bacteria, diminishing of protein synthesis is often accompanied with the formation of ribosomal dimers (or disomes). This process might be particularly important for pathogenic bacteria whose successful survival is a key factor for suc
Externí odkaz:
https://doaj.org/article/e9a5b601c25f4988ba229a787fc8807c
Autor:
Evelina Klochkova, Aydar Bikmullin, Shamil Validov, Natalia Garaeva, Marat Yusupov, Konstantin Usachev
Publikováno v:
International Journal of Biomedicine, Vol 11, Iss Suppl_1, Pp 23-23 (2021)
Background: An essential in bacteria GTPase Era is a multifunctional protein that is involved in cell cycle regulation and appears to play a significant role in ribosome biogenesis. It is required for the maturation of the 30S ribosomal subunit. Era
Externí odkaz:
https://doaj.org/article/5b60659cbbc94e21b220ba5d99848e3a
Autor:
Yuriy Zgadzay, Olga Kolosova, Artem Stetsenko, Konstantin Usachev, Shamil Validov, Albert Guskov, Marat Yusupov
Publikováno v:
International Journal of Biomedicine, Vol 11, Iss Suppl_1, Pp 25-25 (2021)
Background: The fungus Candida albicans is one of the most common fungal human pathogens, causing numerous mucocutaneous infections. About 80% of the world population is colonized with this pathogen, and in many cases, it does not reveal its pathogen
Externí odkaz:
https://doaj.org/article/4cb4f4426c584dce98d90333a6c80e95
Autor:
Natalia Garaeva, Aydar Bikmullin, Evelina Klochkova, Shamil Validov, Marat Yusupov, Konstantin Usachev
Publikováno v:
International Journal of Biomedicine, Vol 11, Iss Suppl_1, Pp 25-25 (2021)
Background: Staphylococcus aureus (S. aureus) is one of the main human pathogens causing numerous nosocomial soft tissue infections and is among the best-known causes of bacterial infections. The bacterial 70S ribosome consists of two subunits, desig
Externí odkaz:
https://doaj.org/article/5a52d678311e49eb9a20abfac4682758