Human oocytes harboring damaged DNA can complete meiosis I

Autor: Rémillard-Labrosse, Gaudeline, Dean, Nicola L., Allais, Adélaïde, Mihajlović, Aleksandar I., Jin, Shao Guang, Son, Weon-Young, Chung, Jin-Tae, Pansera, Melissa, Henderson, Sara, Mahfoudh, Alina, Steiner, Naama, Agapitou, Kristy, Marangos, Petros, Buckett, William, Ligeti-Ruiter, Jacob, FitzHarris, Greg

Publikováno v: In Fertility and Sterility May 2020 113(5):1080-1089

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Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration:explants for the study of neural crest cell delamination and migration

Autor: Gonzalez Malagon, Sandra Guadalupe, Dobson, Lisa, Lopez Munoz, Anna M, Dawson, Marcus, Barrell, William, Marangos, Petros, Krause, Matthias, Liu, Karen J

Publikováno v: Gonzalez Malagon, S G, Dobson, L, Lopez Munoz, A M, Dawson, M, Barrell, W, Marangos, P, Krause, M & Liu, K J 2019, ' Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration : explants for the study of neural crest cell delamination and migration ', Journal of Visualized Experiments, no. 152, e60051 . https://doi.org/10.3791/60051

Over the past several decades there has been an increased availability of genetically modified mouse models used to mimic human pathologies. However, the ability to study cell movements and differentiation in vivo is still very difficult. Neurocristo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2761::dbbb25ede5908f43ebbc15373be4e880
https://kclpure.kcl.ac.uk/en/publications/31da2ef0-112d-4c58-a4d2-86beb21ccd98

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DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age

Autor: Marangos, Petros, Stevense, Michelle, Niaka, Konstantina, Lagoudaki, Michaela, Nabti, Ibtissem, Jessberger, Rolf, Carroll, John

Publikováno v: Nature Communications

In mammalian oocytes DNA damage can cause chromosomal abnormalities that potentially lead to infertility and developmental disorders. However, there is little known about the response of oocytes to DNA damage. Here we find that oocytes with DNA damag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6b5075dc81722488c13668e08d5fe612
http://europepmc.org/articles/PMC4667640