Výsledky vyhledávání - "Maran J.W. Berends"

Toward new strategies to select young endometrial cancer patients for mismatch repair gene mutation analysis

Autor: Marian J.E. Mourits, Tineke van der Sluis, Rolf H. Sijmons, Neeltje Arts, Ying Wu, Harry Hollema, Wietske Boersmavan Ek, Charles H.C.M. Buys, Marjolijn J. L. Ligtenberg, Maran J.W. Berends, Klaske A. ten Hoor, Ate G.J. van der Zee, Elisabeth G.E. de Vries, Jan H. Kleibeuker, Robert M.W. Hofstra

Publikováno v: Journal of Clinical Oncology, 21, 4364-70
Journal of Clinical Oncology, 21(23), 4364-4370. AMER SOC CLINICAL ONCOLOGY
Journal of Clinical Oncology, 21, 23, pp. 4364-70

Purpose: To determine the frequency of mismatch repair (MMR) gene germline mutations in endometrial cancer patients who were diagnosed at less than 50 years of age; to relate the presence of mutations to family history, histopathologic data, presence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3803a2b5fef27c853589ad562f07604a
https://doi.org/10.1200/JCO.2003.04.094

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Germline mutations of EXO1 gene in patients with hereditary nonpolyposis colorectal cancer (HNPCC) and atypical HNPCC forms

Autor: Robert M.W. Hofstra, Ying Wu, Rolf H. Sijmons, Tineke van der Sluis, Maran J.W. Berends, Harry Hollema, E Verlind, Claudia Kempinga, Rob G.J. Mensink, Ate G.J. van der Zee, Jan G. Post, Jan H. Kleibeuker, Charles H.C.M. Buys

Publikováno v: Gastroenterology, 120(7), 1580-1587. W B SAUNDERS CO-ELSEVIER INC

Background & Aims: Germline mutations in one of four mismatch repair genes have been found in the majority of families with hereditary nonpolyposis colorectal cancer (HNPCC), but only in a small part of families with atypical HNPCC. The recently clon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480c8e139cccbf3231eb0d5a53f52134
https://doi.org/10.1053/gast.2001.25117

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Adrenocortical adenocarcinoma in an MSH2 carrier: Coincidence or causal relation?

Autor: Rene C.J. Verschueren, John A. M. Beentjes, Rob G.J. Mensink, Harry Hollema, Arend Karrenbeld, Rolf H. Sijmons, Jan H. Kleibeuker, Maran J.W. Berends, Annemieke Cats, Robert M.W. Hofstra

Publikováno v: Human Pathology, 31(12), 1522-1527. W B SAUNDERS CO-ELSEVIER INC

A woman is described who developed an ovarian adenocarcinoma, 3 metachronous colorectal adenocarcinomas, and a primary adrenocortical adenocarcinoma. Genetic investigation of the mismatch repair genes MLH1 and MSH2 showed a germline mutation in MSH2.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d188c7cbd825f61252cea3521ae5c274
https://doi.org/10.1053/hupa.2000.20409

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Association of Hereditary Nonpolyposis Colorectal Cancer–Related Tumors Displaying Low Microsatellite Instability with MSH6 Germline Mutations

Autor: Rob G.J. Mensink, Rolf H. Sijmons, Ate G.J. van der Zee, Ying Wu, Robert M. W. Hofstra, Harry Hollema, Claudia Kempinga, Jan H. Kleibeuker, Maran J.W. Berends, Charles H.C.M. Buys

Publikováno v: The American Journal of Human Genetics. 65(5):1291-1298

SummaryHereditary nonpolyposis colorectal cancer (HNPCC) (Amsterdam criteria) is often caused by mutations in mismatch repair (MMR) genes, and tumors of patients with HNPCC show microsatellite instability (MSI-high phenotype). Germline mutations of M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4294e770c229e34a251caa67521ba8

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The importance of family history in young patients with endometrial cancer

Autor: Marian J.E. Mourits, Ate G.J. van der Zee, Harry Hollema, Elisabeth Pras, Maran J.W. Berends, Jan H. Kleibeuker, Elisabeth G.E. de Vries

Publikováno v: European Journal of Obstetrics & Gynecology and Reproductive Biology. 82:139-141

Endometrial cancer occurs primarily in postmenopausal women older than 60 years of age. Especially in young patients with endometrial cancer, a positive family history with respect to cancer and/or development of synchronous or metachronous tumors ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd23ff3671a1695e1f7ba44c81d7f8a0
https://doi.org/10.1016/s0301-2115(98)00215-2

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Colorectal cancer and the CHEK2 1100delC mutation

Autor: Gerrit van der Steege, Renee C. Niessen, Elisabeth G.E. de Vries, Gerard J. te Meerman, Jan H. Kleibeuker, Rolf H. Sijmons, Maran J.W. Berends, Robert M.W. Hofstra, Mirjam M. de Jong, Marcel Bruinenberg, Winette T. A. van der Graaf, Michael Schaapveld, Ilja M. Nolte, Marcel Mulder

Publikováno v: GENES CHROMOSOMES & CANCER, 43(4), 377-382. Wiley

The CHEK2 1100delC mutation was recently identified as a low-penetrance breast cancer susceptibility allele. The mutation occurred more frequently in families with clustering of breast and colorectal cancers (CRCs) than in families with clustering of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085dc8f944afdce8e0848667ed6edbad
https://research.rug.nl/en/publications/5c554f3a-96c9-4871-9651-e23efe0f9373

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MLH1 and MSH2 protein expression as a pre-screening marker in hereditary and non-hereditary endometrial hyperplasia and cancer

Autor: Robert M.W. Hofstra, Harry Hollema, Rob G.J. Mensink, Elisabeth G.E. de Vries, Marian J.E. Mourits, Tineke van der Sluis, Rolf H. Sijmons, Ate G.J. van der Zee, Klaske A. ten Hoor, Charles H.C.M. Buys, Elisabeth Pras, Ying Wu, Maran J.W. Berends, Jan H. Kleibeuker

Publikováno v: International journal of cancer. 92(3)

The predictive value of MLH1 or MSH2 protein expression for the presence of truncating germline mutations was examined in benign and (pre)malignant endometrial samples from 3 patient groups: (I) 10 endometrial cancer patients from hereditary non-poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb237fe082b86a886f5c6601fa9bfa6
https://pubmed.ncbi.nlm.nih.gov/11291077

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No association between two MLH3 variants (S845G and P844L) and colorectal cancer risk

Autor: Ying Wu, Elisabeth G.E. de Vries, Winette T. A. van der Graaf, Michael Schaapveld, Jantine L. Westra, Harry Hollema, Krista Kooi, Jan H. Kleibeuker, Maran J.W. Berends, Rolf H. Sijmons, Tineke van der Sluis, Robert M.W. Hofstra, Mirjam M. de Jong, Gerard J. te Meerman

Publikováno v: Cancer Genetics and Cytogenetics, 152(1), 70-71. ELSEVIER SCIENCE INC

Recently we identified a new variant, S845G, in the MLH3 gene in 7 out of 327 patients suspected of hereditary nonpolyposis colorectal cancer but not fulfilling the Amsterdam criteria and in I out of 188 control subjects. As this variant might play a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696a81692d26a132c9892d55053b5c64
https://doi.org/10.1016/j.cancergencyto.2003.10.008

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Identification of germline mismatch repair gene mutation carriers among paitents with multiple Hnpcc-related tumors

Autor: Elisabeth G.E. de Vries, Maran J.W. Berends, Jan H. Kleibeuker, Ate G.J. van der Zee, Harry Hollema, Robert H. Sijmons, Robert M.W. Hofstra, Charles H.C.M. Buys

Publikováno v: Gastroenterology. 124:A550

Hel~ditary nonpolyposis colorectal cancer (HNPCC) results from germline mutations in the rn~nstch repair (MMR) genas, in particular MLHI, MSH2 and MSH6. HNPCC is suspected if a patient has multiple HNPCC-related cancers. Methods: 82 patients with at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::493b6cb0c78053d4fdf02f246945c15d
https://doi.org/10.1016/s0016-5085(03)82780-4

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