Lipocalin-2 induces mitochondrial dysfunction in renal tubular cells via mTOR pathway activation

Autor: Eloïse Marques, Maraiza Alves Teixeira, Clément Nguyen, Fabiola Terzi, Morgan Gallazzini

Publikováno v: Cell Reports, Vol 42, Iss 9, Pp 113032- (2023)

Summary: Mitochondrial dysfunction is a critical process in renal epithelial cells upon kidney injury. While its implication in kidney disease progression is established, the mechanisms modulating it remain unclear. Here, we describe the role of Lipo

Externí odkaz: https://doaj.org/article/1965e843d698442e91e0bdf7f60ba2dc

Both ghrelin deletion and unacylated ghrelin overexpression preserve muscles in aging mice

Autor: Marilisa De Feudis, Roberta Belli, Maurilio Sampaolesi, Ivan Zaggia, Andrea Scircoli, Emanuela Agosti, Flavio Lorenzo Ronzoni, Simone Reano, Tommaso Raiteri, Elisabetta Ferraro, Andrea Graziani, Flavia Prodam, Maraiza Alves Teixeira, Elia Angelino, Edoardo Tamiso, Paola Costelli, Nicoletta Filigheddu, Maurizio Muscaritoli

Publikováno v: Università degli Studi del Piemonte Orientale-IRIS
Aging (Albany NY)

Sarcopenia, the decline in muscle mass and functionality during aging, might arise from age-associated endocrine dysfunction. Ghrelin is a hormone circulating in both acylated (AG) and unacylated (UnAG) forms with anti-atrophic activity on skeletal m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e91c3400262e7ebf4c2808ee326740
https://hdl.handle.net/11568/1053842

Opposing effects of 25-hydroxy- and 1α,25-dihydroxy-vitamin D

Autor: Hana, Sustova, Marilisa, De Feudis, Simone, Reano, Maraiza, Alves Teixeira, Ilaria, Valle, Ivan, Zaggia, Emanuela, Agosti, Flavia, Prodam, Nicoletta, Filigheddu

Publikováno v: Acta physiologica (Oxford, England). 226(3)

Loss of skeletal muscle is one of the main features of cancer cachexia. Vitamin D (VD) deficiency is associated with impairment of muscle mass and performance and is highly prevalent in cachectic patients; therefore, VD supplementation has been propo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::96e3a291b8d3a4a32cffe2065dbd7da1
https://pubmed.ncbi.nlm.nih.gov/30834670

The Adaptor Protein Myd88 Is a Key Signaling Molecule in the Pathogenesis of Irinotecan-Induced Intestinal Mucositis

Autor: Fernando Q. Cunha, Rangel L. Silva, Deysi Viviana Tenazoa Wong, Vanessa F. Borges, Gabriela Loiola Ponte Batista, Cibele Barreto Mano de Carvalho, Carlos W. S. Wanderley, Maraiza Alves Teixeira, Amanda X. Couto Bem, Gerly Anne de Castro Brito, Ronaldo A. Ribeiro, Paulo Roberto Carvalho Almeida, Roberto C. P. Lima-Júnior, Thiago M. Cunha, Caio Abner Leite

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 10, p e0139985 (2015)
Repositório Institucional da Universidade Federal do Ceará (UFC)
Universidade Federal do Ceará (UFC)
instacron:UFC
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Intestinal mucositis is a common side effect of irinotecan-based anticancer regimens. Mucositis causes cell damage, bacterial/endotoxin translocation and production of cytokines including IL–1 and IL–18. These molecules and toll-like receptors (T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38bf8bb2f8ac720e72bed5da4ddd72f
http://europepmc.org/articles/PMC4595146