Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Marah C Runtsch"'
Autor:
Marah C Runtsch, Morgan C Nelson, Soh-Hyun Lee, Warren Voth, Margaret Alexander, Ruozhen Hu, Jared Wallace, Charisse Petersen, Vanja Panic, Claudio J Villanueva, Kimberley J Evason, Kaylyn M Bauer, Timothy Mosbruger, Sihem Boudina, Mary Bronner, June L Round, Micah J Drummond, Ryan M O'Connell
Publikováno v:
PLoS Genetics, Vol 15, Iss 2, p e1007970 (2019)
Identifying regulatory mechanisms that influence inflammation in metabolic tissues is critical for developing novel metabolic disease treatments. Here, we investigated the role of microRNA-146a (miR-146a) during diet-induced obesity in mice. miR-146a
Externí odkaz:
https://doaj.org/article/0b801b0c45b84c1488fd88a3d64a9028
Publikováno v:
Frontiers in Genetics, Vol 5 (2014)
The mammalian intestinal tract is a unique site in which a large portion of our immune system and the 10^14 commensal organisms that make up the microbiota reside in intimate contact with each other. Despite the potential for inflammatory immune resp
Externí odkaz:
https://doaj.org/article/ee8a259b05f241b4b8cea8cfac7ee724
Autor:
Nejra Cosic-Mujkanovic, Paulina Valadez-Cosmes, Kathrin Maitz, Anna Lueger, Zala N. Mihalic, Marah C. Runtsch, Melanie Kienzl, Michael J. Davies, Christine Y. Chuang, Akos Heinemann, Rudolf Schicho, Gunther Marsche, Julia Kargl
Publikováno v:
Antioxidants, Vol 12, Iss 8, p 1587 (2023)
Myeloperoxidase (MPO) is a neutrophil-derived enzyme that has been recently associated with tumour development. However, the mechanisms by which this enzyme exerts its functions remain unclear. In this study, we investigated whether myeloperoxidase c
Externí odkaz:
https://doaj.org/article/682bfad2e156490f964323c66d5ae8f4
Publikováno v:
Journal of neurochemistryREFERENCES. 158(1)
Neuroinflammatory and neurodegenerative diseases are characterized by the recruitment of circulating blood-borne innate and adaptive immune cells into the central nervous system (CNS). These leukocytes sustain the detrimental response in the CNS by r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436533fb80393e36bf97d8f603a7411b
https://pubmed.ncbi.nlm.nih.gov/32880969
https://pubmed.ncbi.nlm.nih.gov/32880969
Autor:
Luke A. J. O'Neill, Marah C. Runtsch
Publikováno v:
Cell Metab
Cell Metabolism
Cell Metabolism
The bacterium Pseudomonas aeruginosa is especially pathogenic, often being associated with intractable pneumonia and high mortality. How P. aeruginosa avoids immune clearance and persists in the inflamed human airway remains poorly understood. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ea3e28d86a5fd8af7969a98f898447
https://pubmed.ncbi.nlm.nih.gov/32428444
https://pubmed.ncbi.nlm.nih.gov/32428444
Autor:
Marah C. Runtsch, Soh-Hyun Lee, H. Atakan Ekiz, Ryan M. O'Connell, Thomas B. Huffaker, Timothy L. Mosbruger, Kaylyn M. Bauer, Warren P. Voth, Morgan C. Nelson, June L. Round, Cindy Barba, William W. Tang, James E. Cox
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Tumor associated macrophage responses are regulated by distinct metabolic states that affect their function. However, the ability of specific signals in the local tumor microenvironment to program macrophage metabolism remains under investigation. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cefb49672322d5c2aa94107b0824f78c
https://pubmed.ncbi.nlm.nih.gov/33976173
https://pubmed.ncbi.nlm.nih.gov/33976173
Autor:
Margaret Alexander, Michael W. Deininger, Soh Hyun Lee, Anna M. Eiring, Rodney R. Miles, Jared Wallace, Thomas B. Huffaker, Timothy L. Mosbruger, Ruozhen Hu, Ami B. Patel, Dominique Kagele, Ryan M. O'Connell, Dinesh S. Rao, Warren P. Voth, Marah C. Runtsch, Carissa N. Kim, June L. Round
Publikováno v:
Blood, vol 129, iss 23
FLT3-ITD+ acute myeloid leukemia (AML) accounts for ∼25% of all AML cases and is a subtype that carries a poor prognosis. microRNA-155 (miR-155) is specifically overexpressed in FLT3-ITD+ AML compared with FLT3 wild-type (FLT3-WT) AML and is critic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd961e2607e411d294793cb995da15a
https://doi.org/10.1182/blood-2016-09-740209
https://doi.org/10.1182/blood-2016-09-740209
Autor:
Erika L. Pearce, Kingston H. G. Mills, Gina Papadopoulou, Harry Kane, Marah C. Runtsch, Eva M. Palsson-McDermott, Stefano Angiari, Nisha Rana, Luke A. J. O'Neill, Caroline E. Sutton, Beth Kelly
Publikováno v:
Cell Metabolism
Summary Pyruvate kinase (PK) catalyzes the conversion of phosphoenolpyruvate to pyruvate during glycolysis. The PK isoform PKM2 has additional roles in regulation of gene transcription and protein phosphorylation. PKM2 has been shown to control macro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cef3028fd34cbb1a275a72792b3559d
http://europepmc.org/articles/PMC7001035
http://europepmc.org/articles/PMC7001035
Autor:
Ryan M. O'Connell, Charisse Petersen, Marah C. Runtsch, Vanja Panic, Warren P. Voth, Micah J. Drummond, Claudio J. Villanueva, Ruozhen Hu, Margaret Alexander, Soh-Hyun Lee, Morgan C. Nelson, Kimberley J. Evason, June L. Round, Jared Wallace, Kaylyn M. Bauer, Mary P. Bronner, Sihem Boudina, Timothy L. Mosbruger
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 15, Iss 2, p e1007970 (2019)
PLoS Genetics, Vol 15, Iss 2, p e1007970 (2019)
Identifying regulatory mechanisms that influence inflammation in metabolic tissues is critical for developing novel metabolic disease treatments. Here, we investigated the role of microRNA-146a (miR-146a) during diet-induced obesity in mice. miR-146a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7973ecd06c1f695a4af4e7708224feb
https://pubmed.ncbi.nlm.nih.gov/30768595
https://pubmed.ncbi.nlm.nih.gov/30768595
Autor:
Evanna L. Mills, Dylan G. Ryan, Deepthi Menon, Michael P. Murphy, Anne F. McGettrick, Richard C. Hartley, Elena V. Knatko, Edward T. Chouchani, Marah C. Runtsch, Paul J. Meakin, Mark M. Hughes, Maureen Higgins, Richard G. Carroll, Lee M. Booty, Dina Dikovskaya, Padraic G. Fallon, Daniel C. Sévin, Mark P. Jedrychowski, Christian Frezza, Gino Brunori, Joanna F. McGouran, Roman Fischer, Michael L.J. Ashford, Emily Hams, Louise K. Modis, Martin S. King, Hiran A. Prag, John Szpyt, Stuart T. Caldwell, Edmund R.S. Kunji, Benedikt M. Kessler, Ana S. H. Costa, Albena T. Dinkova-Kostova, Zbigniew Zaslona, Luke A. J. O'Neill
Publikováno v:
Nature. 556(7699)
The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function, but its precise mechanism of action remains poorly understood1,2,3. Here we show that itaconate is required for the activation of the anti-inflammatory tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a845963587a3e1de2e622af776d8af
http://ora.ox.ac.uk/objects/uuid:
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