Targeted therapy for pediatric diffuse intrinsic pontine glioma: a single-center experience

Autor: Giada Del Baldo, Andrea Carai, Rachid Abbas, Antonella Cacchione, Mara Vinci, Valentina Di Ruscio, Giovanna Stefania Colafati, Sabrina Rossi, Francesca Diomedi Camassei, Nicola Maestro, Sara Temelso, Giulia Pericoli, Emmanuel De Billy, Isabella Giovannoni, Alessia Carboni, Martina Rinelli, Emanuele Agolini, Alan Mackay, Chris Jones, Silvia Chiesa, Mario Balducci, Franco Locatelli, Angela Mastronuzzi

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 14 (2022)

Background: Diffuse intrinsic pontine glioma (DIPG) is a fatal disease with a median overall survival (OS) of less than 12 months after diagnosis. Radiotherapy (RT) still remains the mainstay treatment. Several other therapeutic strategies have been

Externí odkaz: https://doaj.org/article/6424a769c3b241c4b0d3dc614eda6a04

Droplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patients

Autor: Chris Jones, Natacha Entz-Werle, Paula Proszek, Angela Mastronuzzi, Alan Mackay, Daniel Rodriguez, Giulia Pericoli, Darren Hargrave, Sara Temelso, Matthew Clarke, Mike Hubank, Mara Vinci, Paul S. Morgan, Elisa Izquierdo, Fernando Carceller, Lynley V. Marshall, Tim Jaspan, Diana Carvalho, Simon Bailey, Gilles Vassal, Zdenek Pavelka, Birgitta Lannering, Jacques Grill

Publikováno v: Neuro-oncology Advances

Background The use of liquid biopsy is of potential high importance for children with high grade (HGG) and diffuse midline gliomas (DMG), particularly where surgical procedures are limited, and invasive biopsy sampling not without risk. To date, howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db39dc2df706f8cce7894ffb1219e71a
https://doi.org/10.1093/noajnl/vdab013

Functional diversity and co-operativity between subclonal populations of paediatric glioblastoma and diffuse intrinsic pontine glioma cells

Autor: Andrew J. Martin, Elizabeth Y. Qin, Ofelia Cruz, Leslie R. Bridges, Jaume Mora, Andrew S. Moore, Natacha Entz-Werle, Henry Mandeville, Carmen de Torres, Kathryn R. Taylor, Sucheta Vaidya, Christopher J. Lord, Angel M. Carcaboso, Lynley V. Marshall, Valeria Molinari, Ketty Kessler, Diana Carvalho, Mariona Suñol, Dorra H'mida-Ben Brahim, Anna Burford, Wendy J. Ingram, Tim Forshew, Mara Vinci, Michelle Monje, Alice Gutteridge, Christopher Chandler, Ho Keung Ng, Saoussen Trabelsi, Matthew Clarke, Sergey V. Popov, Helen Pemberton, Chris Jones, Safa Al-Sarraj, Stergios Zacharoulis, Alan Mackay

Publikováno v: Nature medicine
NATURE MEDICINE
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu

The failure to develop effective therapies for paediatric glioblastoma (pGBM) and diffuse intrinsic pontine glioma (DIPG) is in part due to their intrinsic heterogeneity. We aimed to quantitatively map assess the extent to which this was present in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c676260dd12a1b533e825e93c925fb5e
http://europepmc.org/articles/PMC6086334

Abstract 1932: Mutations in ATRX increase genetic instability and sensitivity to PARP inhibitors in paediatric glioblastoma cells

Autor: Christopher J. Lord, Diana Carvalho, Stephen J. Pettitt, Helen Pemberton, Chris Jones, Alan Mackay, Lynn Bjerke, Mara Vinci, Janat Fazal-Salom

Publikováno v: Cancer Research. 77:1932-1932

Paediatric glioblastomas (pGBM) are amongst the most common causes of cancer-related deaths in children, and are defined by highly recurrent mutations in H3 histones. Mutations affecting the chromatin remodeling protein ATRX have been reported in 30%

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87fb67f317634a4dd30b5e07b3f4c6e5
https://doi.org/10.1158/1538-7445.am2017-1932

Myoblast-mediated gene therapy via encephalomyosynangiosis – A novel strategy for local delivery of gene products to the brain surface

Autor: Nils Hecht, Johannes Woitzik, Pablo Peña-Tapia, Georges von Degenfeld, Mara Vinci, Peter Vajkoczy

Publikováno v: Journal of Neuroscience Methods. 201:61-66

An encephalomyosynangiosis (EMS) is a temporal muscle graft that is placed onto the surface of the brain to serve as a source for collateral vessel growth for brain revascularization in patients with Moyamoya Disease (MMD). To facilitate an EMS in pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae13e26f3ecc31031713625b82f3118
https://doi.org/10.1016/j.jneumeth.2011.07.011