Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Mara Schvarzstein"'
Publikováno v:
Journal of Developmental Biology, Vol 11, Iss 2, p 26 (2023)
Whole genome duplication (WGD) or polyploidization can occur at the cellular, tissue, and organismal levels. At the cellular level, tetraploidization has been proposed as a driver of aneuploidy and genome instability and correlates strongly with canc
Externí odkaz:
https://doaj.org/article/7e5bbe89ea5d4e8cbf0a5437fc6fd9a9
Publikováno v:
Cell Cycle
Centrosomes are organelles that function as hubs of microtubule nucleation and organization, with key roles in organelle positioning, asymmetric cell division, ciliogenesis, and signaling. Aberrant centrosome number, structure or function is linked t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2322fb175bc4af3397b109f49c229a63
Autor:
Erlyana K, Clarke, Katherine A, Rivera Gomez, Zaki, Mustachi, Mikaela C, Murph, Mara, Schvarzstein
Publikováno v:
Journal of Visualized Experiments : JoVE
Mechanisms that involve whole genome polyploidy play important roles in development and evolution; also, an abnormal generation of tetraploid cells has been associated with both the progression of cancer and the development of drug resistance. Until
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bbf3e696eb7064b226afd6edc7be3580
https://pubmed.ncbi.nlm.nih.gov/29608173
https://pubmed.ncbi.nlm.nih.gov/29608173
Publikováno v:
Genetics. 201:1363-1379
Meiotic chromosome segregation requires pairwise association between homologs, stabilized by the synaptonemal complex (SC). Here, we investigate factors contributing to pairwise synapsis by investigating meiosis in polyploid worms. We devised a strat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6ad111a08900853a8be7c76abca0e8
https://doi.org/10.1534/genetics.115.182279
https://doi.org/10.1534/genetics.115.182279
Publikováno v:
Genes & Development. 24:219-228
Organisms that reproduce sexually must reduce their chromosome number by half during meiosis to generate haploid gametes. To achieve this reduction in ploidy, organisms must devise strategies to couple sister chromatids so that they stay together dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93ee888125cc85ab05f548e82c9cc73
https://doi.org/10.1101/gad.1863610
https://doi.org/10.1101/gad.1863610
Autor:
Andrew M. Spence, Mara Schvarzstein
Publikováno v:
Developmental Cell. 11(5):733-740
SummaryTRA-1A is the sole representative in Caenorhabditis elegans of the Gli transcription factor family. Its activity is required to specify all somatic female cell fates in XX hermaphrodites. We have found that TRA-1 protein levels are much higher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52436254152038612611c777f6adbf6
Autor:
Mara Schvarzstein, Yuko Chigira, Kiyoji Nishiwaki, Naoki Hisamoto, Yoshifumi Jigami, Maho Suzuki, Kunihiro Matsumoto, Samir Kumar Roy, Yukihiko Kubota
Publikováno v:
Nature Cell Biology. 6:31-37
In the nematode Caenorhabditis elegans, the gonad acquires two U-shaped arms through the directed migration of its distal tip cells (DTCs), which are located at the tip of the growing gonad arms. A member of the ADAM (a disintegrin and metalloproteas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b61111662f789edaa5f12dd54c16af
https://doi.org/10.1038/ncb1079
https://doi.org/10.1038/ncb1079
Autor:
Angela Tam, Enrique Martinez-Perez, Simona Rosu, Baptiste Roelens, Divya Pattabiraman, Mara Schvarzstein, Kentaro Nabeshima, Ajit Ramadugu, Karl A. Zawadzki, Anne M. Villeneuve, Rayka Yokoo, Barbara J Meyer, Aaron F. Severson, Diana E. Libuda
Publikováno v:
Schvarzstein, M; Pattabiraman, D; Libuda, DE; Ramadugu, A; Tam, A; Martinez-Perez, E; et al.(2014). DNA helicase HIM-6/BLM both promotes mutSγ-dependent crossovers and antagonizes mutSγ-independent interhomolog associations during Caenorhabditis elegans meiosis. Genetics, 198(1), 193-207. doi: 10.1534/genetics.114.161513. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/8628h4tq
Meiotic recombination is initiated by the programmed induction of double-strand DNA breaks (DSBs), lesions that pose a potential threat to the genome. A subset of the DSBs induced during meiotic prophase become designated to be repaired by a pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de2381c0d44c89ee8ea89353e6c0e4b
https://europepmc.org/articles/PMC4174932/
https://europepmc.org/articles/PMC4174932/
Publikováno v:
Mechanisms of Development. 80(2):223-226
We have identified Zkrml2, a novel homologue of the segmentation gene Krml/val in zebrafish (Danio rerio). Zkrml2 shows 72% and 92% identity in its basic leucine zipper domain with mouse Krml1 and zebrafish val, respectively. Zkrml2 is expressed coin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531366b0580fdbfaeac552faeeb3840f
Publikováno v:
Proceedings of the National Academy of Sciences. 110
In many species where oocytes lack centrosomes, sperm contribute both genetic material and centriole(s) to the zygote. Correct centriole organization during male meiosis is critical to guarantee a normal bipolar mitotic spindle in the zygote. During
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6646bb382124c2cebaeafd6e4492a4
https://doi.org/10.1073/pnas.1213888110
https://doi.org/10.1073/pnas.1213888110