Výsledky vyhledávání - "Mara P. Berzins"

Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tolerability, protective efficacy and humoral immunogenicity

Publikováno v: Malaria Journal

Background In this phase 1 clinical trial, healthy adult, malaria-naïve subjects were immunized with radiation-attenuated Plasmodium falciparum sporozoites (PfRAS) by mosquito bite and then underwent controlled human malaria infection (CHMI). The Pf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406e762eaba567d96b5aeccb46ecc571
http://europepmc.org/articles/PMC4957371

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Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA

Publikováno v: Human Vaccines & Immunotherapeutics

When introduced in the 1990s, immunization with DNA plasmids was considered potentially revolutionary for vaccine development, particularly for vaccines intended to induce protective CD8 T cell responses against multiple antigens. We conducted, in 19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3349b913bc019d182aeda4a155241fa
http://europepmc.org/articles/PMC3601132

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The US Capitol Bioterrorism Anthrax Exposures: Clinical Epidemiological and Immunological Characteristics

Autor: Lori L. Shatney, Lolita Bebris, Daniel Freilich, Norma L. Graber, Gregory J. Martin, Robert L. Bull, Maria F. Malone, Denise L. Doolan, Jason Dabbs, Mara P. Berzins, John F. Eisold, Alfred J. Mateczun, David L. Blazes, Timothy Burgess, Gary T. Brice

Publikováno v: The Journal of Infectious Diseases. 195:174-184

Background: Bioterrorism-related anthrax exposures occurred at the US Capitol in 2001. Exposed individuals received antibiotics and anthrax vaccine adsorbed immunization. Methods: A prospective longitudinal study of 124 subjects—stratified on the b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eedeaafa74a7ae0e080566d711a913f
https://doi.org/10.1086/510312

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Safety, tolerability, and antibody responses in humans after sequential immunization with a PfCSP DNA vaccine followed by the recombinant protein vaccine RTS,S/AS02A

Publikováno v: Vaccine. 22:1592-1603

Optimal protection against malaria may require induction of high levels of protective antibody and CD8(+) and CD4(+) T cell responses. In humans, malaria DNA vaccines elicit CD8(+) cytotoxic T cells (CTL) and IFNgamma responses as measured by short-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5ebe16a8ba265566fd9def92b53410
https://doi.org/10.1016/j.vaccine.2004.01.031

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HBOC-201 vasoactivity in a phase III clinical trial in orthopedic surgery subjects--extrapolation of potential risk for acute trauma trials

Autor: Daniel Freilich, Mara P. Berzins, L. Bruce Pearce, Arkadiy Pitman, Richard M. McCarron, Gerson Greenburg, Steven Ahlers, Lolita Bebris

Publikováno v: The Journal of trauma. 66(2)

BACKGROUND Vasoactivity has hampered progress of hemoglobin-based oxygen carriers (HBOCs) due to concern for adverse blood pressure responses and secondary complications. A recent formulation, highly polymerized HBOC-201 (Biopure, Cambridge, MA), has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f393bad93455df002a145be2418701
https://pubmed.ncbi.nlm.nih.gov/19204509

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