Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Mara Mazzola"'
1
Akademický článek
ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish
Autor: Alessia Brix, Laura Belleri, Alex Pezzotta, Emanuela Pettinato, Mara Mazzola, Matteo Zoccolillo, Anna Marozzi, Rui Monteiro, Filippo Del Bene, Alessandra Mortellaro, Anna Pistocchi
Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Deficiency of adenosine deaminase 2 (DADA2) is an inborn error of immunity caused by loss-of-function mutations in the adenosine deaminase 2 (ADA2) gene. Clinical manifestations of DADA2 include vasculopathy and immuno-hematological abnormal
Externí odkaz: https://doaj.org/article/b91819917852418395db5a72ed44b50e
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2
Akademický článek
Extracellular vesicles mediate the communication between multiple myeloma and bone marrow microenvironment in a NOTCH dependent way
Autor: Domenica Giannandrea, Natalia Platonova, Michela Colombo, Mara Mazzola, Valentina Citro, Raffaella Adami, Filippo Maltoni, Silvia Ancona, Vincenza Dolo, Ilaria Giusti, Andrea Basile, Anna Pistocchi, Laura Cantone, Valentina Bollati, Lavinia Casati, Elisabetta Calzavara, Mauro Turrini, Elena Lesma, Raffaella Chiaramonte
Publikováno v: Haematologica, Vol 107, Iss 9 (2022)
Multiple myeloma (MM) is an incurable hematologic neoplasm, whose poor prognosis is deeply affected by the propensity of tumor cells to localize in the bone marrow (BM) and induce the protumorigenic activity of normal BM cells, leading to events asso
Externí odkaz: https://doaj.org/article/c195eedfb9354de7a10e37e74ad06210
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3
Akademický článek
HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia
Autor: Marco Spreafico, Alicja M. Gruszka, Debora Valli, Mara Mazzola, Gianluca Deflorian, Arianna Quintè, Maria Grazia Totaro, Cristina Battaglia, Myriam Alcalay, Anna Marozzi, Anna Pistocchi
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Histone deacetylase 8 (HDAC8), a class I HDAC that modifies non-histone proteins such as p53, is highly expressed in different hematological neoplasms including a subtype of acute myeloid leukemia (AML) bearing inversion of chromosome 16 [inv(16)]. T
Externí odkaz: https://doaj.org/article/9cdbd03a639740c7b6951f3d103b0f9c
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4
Akademický článek
Multiple myeloma exploits Jagged1 and Jagged2 to promote intrinsic and bone marrow-dependent drug resistance
Autor: Michela Colombo, Silvia Garavelli, Mara Mazzola, Natalia Platonova, Domenica Giannandrea, Raffaella Colella, Luana Apicella, Marialuigia Lancellotti, Elena Lesma, Silvia Ancona, Maria Teresa Palano, Marzia Barbieri, Elisa Taiana, Elisa Lazzari, Andrea Basile, Mauro Turrini, Anna Pistocchi, Antonino Neri, Raffaella Chiaramonte
Publikováno v: Haematologica, Vol 105, Iss 7 (2020)
Multiple myeloma is still incurable due to an intrinsic aggressiveness or, more frequently, to the interactions of malignant plasma cells with the bone marrow (BM) microenvironment. Myeloma cells educate BM cells to support neoplastic cell growth, su
Externí odkaz: https://doaj.org/article/85ae0254d5694b439cd66c63b07a3f34
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5
Akademický článek
NIPBL: a new player in myeloid cell differentiation
Autor: Mara Mazzola, Gianluca Deflorian, Alex Pezzotta, Laura Ferrari, Grazia Fazio, Erica Bresciani, Claudia Saitta, Luca Ferrari, Monica Fumagalli, Matteo Parma, Federica Marasca, Beatrice Bodega, Paola Riva, Franco Cotelli, Andrea Biondi, Anna Marozzi, Gianni Cazzaniga, Anna Pistocchi
Publikováno v: Haematologica, Vol 104, Iss 7 (2019)
The nucleophosmin 1 gene (NPM1) is the most frequently mutated gene in acute myeloid leukemia. Notably, NPM1 mutations are always accompanied by additional mutations such as those in cohesin genes RAD21, SMC1A, SMC3, and STAG2 but not in the cohesin
Externí odkaz: https://doaj.org/article/2a860a51750740278fb6788ba7cc49e3
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6
Akademický článek
Enigmatic Ladies of the Rings: How Cohesin Dysfunction Affects Myeloid Neoplasms Insurgence
Autor: Alex Pezzotta, Mara Mazzola, Marco Spreafico, Anna Marozzi, Anna Pistocchi
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 7 (2019)
The genes of the cohesin complex exert different functions, ranging from the adhesion of sister chromatids during the cell cycle, DNA repair, gene expression and chromatin architecture remodeling. In recent years, the improvement of DNA sequencing te
Externí odkaz: https://doaj.org/article/6ff740f75dc44da6ba33d2a7776e66de
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8
Dysregulation of NIPBL leads to impaired RUNX1 expression and haematopoietic defects
Autor: Alessandra Rigamonti, Matteo Parma, Mara Mazzola, Grazia Fazio, Luca Ferrari, Erica Bresciani, Anna Marozzi, Claudia Saitta, Germano Gaudenzi, Andrea Biondi, Giovanni Cazzaniga, Anna Pistocchi, Monica Fumagalli, Alex Pezzotta, Maria Chiara Pelleri
Publikováno v: Journal of Cellular and Molecular Medicine
The transcription factor RUNX1, a pivotal regulator of HSCs and haematopoiesis, is a frequent target of chromosomal translocations, point mutations or altered gene/protein dosage. These modifications lead or contribute to the development of myelodysp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94687ea07c3a66063b33cf7639b01b00
https://doi.org/10.1111/jcmm.15269
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9
The Genome-Wide Impact of
Autor: Marco, Spreafico, Eleonora, Mangano, Mara, Mazzola, Clarissa, Consolandi, Roberta, Bordoni, Cristina, Battaglia, Silvio, Bicciato, Anna, Marozzi, Anna, Pistocchi
Publikováno v: International Journal of Molecular Sciences
Transcriptional changes normally occur during development but also underlie differences between healthy and pathological conditions. Transcription factors or chromatin modifiers are involved in orchestrating gene activity, such as the cohesin genes a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::58eaf09c87126bdbbece98af49ff03b5
https://pubmed.ncbi.nlm.nih.gov/33352756
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10
The Genome-wide impact of Nipblb loss-of-function on Zebrafish gene expression
Autor: Roberta Bordoni, Eleonora Mangano, Anna Marozzi, Clarissa Consolandi, Mara Mazzola, Cristina Battaglia, Marco Spreafico, Anna Pistocchi, Silvio Bicciato
Publikováno v: International journal of molecular sciences
21 (2020): 1–12. doi:10.3390/ijms21249719
info:cnr-pdr/source/autori:Spreafico M.; Mangano E.; Mazzola M.; Consolandi C.; Bordoni R.; Battaglia C.; Bicciato S.; Marozzi A.; Pistocchi A./titolo:The Genome-wide impact of Nipblb loss-of-function on Zebrafish gene expression/doi:10.3390%2Fijms21249719/rivista:International journal of molecular sciences (Print)/anno:2020/pagina_da:1/pagina_a:12/intervallo_pagine:1–12/volume:21
International Journal of Molecular Sciences
Volume 21
Issue 24
International Journal of Molecular Sciences, Vol 21, Iss 9719, p 9719 (2020)
Transcriptional changes normally occur during development but also underlie differences between healthy and pathological conditions. Transcription factors or chromatin modifiers are involved in orchestrating gene activity, such as the cohesin genes a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78883717083b0d9dc2e8fddf5c33d597
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