DNMT3B supports meso-endoderm differentiation from mouse embryonic stem cells

Autor: Andrea Lauria, Guohua Meng, Valentina Proserpio, Stefania Rapelli, Mara Maldotti, Isabelle Laurence Polignano, Francesca Anselmi, Danny Incarnato, Anna Krepelova, Daniela Donna, Chiara Levra Levron, Giacomo Donati, Ivan Molineris, Francesco Neri, Salvatore Oliviero

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

DNMT3B-dependent DNA methylation provides epigenetic priming at epiblast stage by methylating enhancers of ectodermal genes to ensure proper differentiation toward mesoendoderm tissues.

Externí odkaz: https://doaj.org/article/cb450db784f44688b9d5f729065610a8

Myc and max genome-wide binding sites analysis links the Myc regulatory network with the polycomb and the core pluripotency networks in mouse embryonic stem cells.

Autor: Anna Krepelova, Francesco Neri, Mara Maldotti, Stefania Rapelli, Salvatore Oliviero

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e88933 (2014)

Myc is a master transcription factor that has been demonstrated to be required for embryonic stem cell (ESC) pluripotency, self-renewal, and inhibition of differentiation. Although recent works have identified several Myc-targets in ESCs, the list of

Externí odkaz: https://doaj.org/article/95ef5c7e72b54ffdab9f00496f497130

The acetyltransferase p300 is recruited in trans to multiple enhancer sites by lncSmad7

Autor: Mara Maldotti, Andrea Lauria, Francesca Anselmi, Ivan Molineris, Annalaura Tamburrini, Guohua Meng, Isabelle Laurence Polignano, Mirko Giuseppe Scrivano, Fabiola Campestre, Lisa Marie Simon, Stefania Rapelli, Edoardo Morandi, Danny Incarnato, Salvatore Oliviero

Publikováno v: Nucleic Acids Research, 50(5):gkac083, 2587-2602. Oxford University Press

The histone acetyltransferase p300 (also known as KAT3B) is a general transcriptional coactivator that introduces the H3K27ac mark on enhancers triggering their activation and gene transcription. Genome-wide screenings demonstrated that a large fract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c0b947a4eb0e6609c0421e4a1f0dcf
https://research.rug.nl/en/publications/b53bf097-bee2-40e7-b52d-11729392e38d

Genome-wide analysis of smad7-mediated transcription in mouse embryonic stem cells

Autor: Guohua Meng, Andrea Lauria, Mara Maldotti, Francesca Anselmi, Isabelle Laurence Polignano, Stefania Rapelli, Daniela Donna, Salvatore Oliviero

Publikováno v: International Journal of Molecular Sciences; Volume 22; Issue 24; Pages: 13598
International Journal of Molecular Sciences, Vol 22, Iss 13598, p 13598 (2021)
International Journal of Molecular Sciences

Smad7 has been identified as a negative regulator of the transforming growth factor TGF-β pathway by direct interaction with the TGF-β type I receptor (TβR-I). Although Smad7 has also been shown to play TGF-β unrelated functions in the cytoplasm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44fb6ae37ca4f2f2ca21415c433f1f5
http://hdl.handle.net/2318/1834543

High-throughput single-base resolution mapping of RNA 2-O-methylated residues

Autor: Danny Incarnato, Salvatore Oliviero, Giulia Basile, Francesco Neri, Edoardo Morandi, Caterina Parlato, Stefania Rapelli, Mara Maldotti, Francesca Anselmi

Publikováno v: Nucleic acids research, 45(3):1433–1441
Nucleic Acids Research, 45(3), 1433-1441. Oxford University Press
Nucleic Acids Research

Functional characterization of the transcriptome requires tools for the systematic investigation of RNA post-transcriptional modifications. 2΄-O-methylation (2΄-OMe) of the ribose moiety is one of the most abundant post-transcriptional modification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da2a6752452a62fec72e75fbd46039c1
http://hdl.handle.net/2318/1764075