Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mara Comini"'
Autor:
Vigilio Ballabeni, Marco Mor, Giovanni Morini, Fabrizio Bordi, Pier Vincenzo Plazzi, Simona Bertoni, Francesca Saccani, Mirko Rivara, Silvia Rivara, Lisa Flammini, Elisabetta Barocelli, Mara Comini
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:9911-9924
The combination of antagonism at histamine H 3 receptors and inhibition of acetylcholinesterase has been recently proposed as an approach to devise putative new therapeutic agents for cognitive diseases. The 4,4′-biphenyl fragment has been reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276bb749a3af437a3fc6188d8b462801
https://doi.org/10.1016/j.bmc.2008.10.029
https://doi.org/10.1016/j.bmc.2008.10.029
Autor:
Giovanni Morini, Vigilio Ballabeni, Simona Bertoni, Mara Comini, Elisabetta Barocelli, Giuseppe Domenichini, Mirko Rivara, Lisa Flammini, Francesca Saccani
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 378:335-343
The pharmacological profiling of potent histamine H(3)-ligands initiated in a previous study is completed here. In vitro functional and binding studies revealed that several derivatives were selective H(3)-antagonists with nanomolar potency at human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a23fa23e2593183fe1c84aef2c9f70
https://doi.org/10.1007/s00210-008-0299-2
https://doi.org/10.1007/s00210-008-0299-2
Autor:
Elisabetta Barocelli, Vigilio Ballabeni, Simona Bertoni, Veronica Manenti, Mara Comini, Giovanni Morini, Lisa Flammini
Publikováno v:
Pharmacological Research. 55:111-116
In this report, we describe the pharmacological profile of alkylpiperidine derivatives at human histamine H 3 receptors and their ability to access central histamine H 3 receptors in rodents. The three most attractive compounds exhibit high affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbd120c7d2fb86dcc187def91f6df6f
https://doi.org/10.1016/j.phrs.2006.10.011
https://doi.org/10.1016/j.phrs.2006.10.011
Autor:
Paola Vicini, Giovanni Morini, Ada Ricci, Matteo Incerti, Enrico Rolli, Camillo Branca, Mara Comini
Publikováno v:
Plant Growth Regulation. 50:201-209
The present research investigates the biological profile of eight symmetrical diheteroarylureas and phenylheteroarylureas, testing their hypothetical cytokinin-like activity and rooting activity. Cytokinin-like activity was assayed by the betacyanin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b95c26608a2169d902ee052b007a24a
https://doi.org/10.1007/s10725-006-9119-1
https://doi.org/10.1007/s10725-006-9119-1
Autor:
Giuseppe Cocconcelli, Mara Comini, Vigilio Ballabeni, Giovanni Morini, Fabrizio Bordi, Marco Mor, Simona Bertoni, Mirko Rivara, Elisabetta Barocelli, Pier Vincenzo Plazzi, Silvia Rivara, Valentina Zuliani
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:1413-1424
A novel series of non-imidazole H(3)-receptor antagonists was developed, by chemical modification of a potent lead H(3)-antagonist composed by an imidazole ring connected through an alkyl spacer to a 2-aminobenzimidazole moiety (e.g., 2-[[3-[4(5)-imi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44797b06ce427d0a37b689998c53f06c
https://doi.org/10.1016/j.bmc.2005.09.063
https://doi.org/10.1016/j.bmc.2005.09.063
Publikováno v:
Il Farmaco. 60:810-817
The synthesis of 3-methoxy-1,2-benzisothiazole derivatives, substituted in position 5- (compounds 1-7) or 7- (compounds 8-14), with oxypropanolaminic side chains and the pharmacological investigation on their activity at beta-adrenoceptors are descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d324a0c9d147a816b319cfe30b2475
https://doi.org/10.1016/j.farmac.2005.07.008
https://doi.org/10.1016/j.farmac.2005.07.008
Autor:
Mara Comini, Vigilio Ballabeni, Lisa Flammini, Massimo Coruzzi, Francesca Saccani, Elisabetta Barocelli, Simona Bertoni, Matteo Incerti, Giovanni Morini
Publikováno v:
ChemMedChem. 5(7)
Dual-acting compounds that combine H 3 antagonism with anticholinesterase properties are currently emerging as a novel and promising therapeutic approach in the treatment of multi-factorial disorders primarily characterized by cholinergic deficits su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b02d001586b2feb138925740f5a83f
https://pubmed.ncbi.nlm.nih.gov/20512794
https://pubmed.ncbi.nlm.nih.gov/20512794
Autor:
Matteo Incerti, Mara Comini, Cristina Pozzoli, Ornella Azzolina, Enzo Poli, Simona Collina, Elena Di Vittorio, Giovanni Morini, Daniela Rossi
Publikováno v:
Chirality. 21(2)
We performed the asymmetric synthesis of four enantiopure benzo[d] isothiazo-3-or 5-yloxypropanolamine derivatives, previously described as competitive antagonists at beta-adrenoceptors. The chemical characterization of each enantiomer was accomplish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0895ef8b3c988ba8e40eba1caa9ddcf
https://pubmed.ncbi.nlm.nih.gov/18537163
https://pubmed.ncbi.nlm.nih.gov/18537163
Autor:
Marco Mor, Mara Comini, Lisa Flammini, Simona Bertoni, Vigilio Ballabeni, Simone Lorenzi, Silvia Rivara, Mirko Rivara, Giovanni Morini, Fabrizio Bordi, Pier Vincenzo Plazzi, Elisabetta Barocelli
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(15)
A class of rigid, dibasic, non-imidazole H 3 antagonists was developed, starting from a series of previously described flexible compounds. The original polymethylene chain between two tertiary amine groups was replaced by a rigid scaffold, composed b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9046444ce3dc68fadaa4b6209ff94761
https://pubmed.ncbi.nlm.nih.gov/16713264
https://pubmed.ncbi.nlm.nih.gov/16713264
Autor:
Veronica Manenti, Mariannina Impicciatore, Giovanni Morini, Simona Bertoni, Elisabetta Barocelli, Mara Comini, Vigilio Ballabeni, Lisa Flammini
Publikováno v:
Pharmacological research. 53(3)
The histamine H3 receptor subtype negatively modulates the release of various neurotransmitters such as histamine, glutamate, norepinephrine, acetylcholine and many others mainly in the CNS and H3 antagonists have been developed to treat central dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f636980e7cfd28f0906656d8dac17459
https://pubmed.ncbi.nlm.nih.gov/16364652
https://pubmed.ncbi.nlm.nih.gov/16364652