Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Mara, Caputo"'
Autor:
Ying Xia, Emma Andersson, Mara Caputo, Emmelie Cansby, Francesca Sedda, Ferran Font-Gironès, Johan Ruud, Yeshwant Kurhe, Bengt Hallberg, Hanns-Ulrich Marschall, Ingrid Wernstedt Asterholm, Stefano Romeo, Matthias Blüher, Margit Mahlapuu
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-17 (2023)
Abstract Objective Non-alcoholic fatty liver disease (NAFLD), the primary hepatic consequence of obesity, is affecting about 25% of the global adult population. The aim of this study was to examine the in vivo role of STE20-type protein kinase TAOK3,
Externí odkaz:
https://doaj.org/article/ed27c68085444033bd938c6b5b7e6d15
Publikováno v:
Hepatology Communications, Vol 6, Iss 10, Pp 2613-2622 (2022)
Abstract Nonalcoholic fatty liver disease (NAFLD) is defined by excessive accumulation of lipid droplets within hepatocytes. The STE20‐type kinases comprising the germinal center kinase III (GCKIII) subfamily – MST3, MST4, and STK25 – decorate
Externí odkaz:
https://doaj.org/article/709232327dc04334af041bb3bed1eb27
Autor:
Mara Caputo, Emma Andersson, Ying Xia, Wei Hou, Emmelie Cansby, Max Erikson, Dan Emil Lind, Bengt Hallberg, Manoj Amrutkar, Margit Mahlapuu
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2446 (2024)
Metabolic dysfunction-associated steatotic liver disease (MASLD) and its advanced subtype, metabolic dysfunction-associated steatohepatitis (MASH), have emerged as the most common chronic liver disease worldwide, yet there is no targeted pharmacother
Externí odkaz:
https://doaj.org/article/952f87d58f5d4c178014238e0af78fc8
Autor:
Emmelie Cansby, Sima Kumari, Mara Caputo, Ying Xia, Rando Porosk, Jonathan Robinson, Hao Wang, Britt-Marie Olsson, Josefine Vallin, Julie Grantham, Ursel Soomets, L. Thomas Svensson, Carina Sihlbom, Hanns-Ulrich Marschall, Andreas Edsfeldt, Isabel Goncalves, Margit Mahlapuu
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Silencing of STK25, an STE20-type kinase, in human aortic endothelial and smooth muscle cells reduces lipid accumulation and suppresses inflammation and fibrotic pathways, ultimately exerting atheroprotective effects.
Externí odkaz:
https://doaj.org/article/c671ada46a694cea94aa6e66b65dc4a6
Autor:
Yeshwant Kurhe, Mara Caputo, Emmelie Cansby, Ying Xia, Sima Kumari, Sumit Kumar Anand, Brian W. Howell, Hanns-Ulrich Marschall, Margit Mahlapuu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 405-423 (2022)
Background & Aims: Hepatocellular carcinoma (HCC) is one of the most fatal and fastest-growing cancers. Recently, nonalcoholic steatohepatitis (NASH) has been recognized as a major catalyst for HCC. Thus, additional research is critically needed to i
Externí odkaz:
https://doaj.org/article/2aae9a7a51ed423ebe5176502440c120
Autor:
Mara Caputo, Emmelie Cansby, Sima Kumari, Yeshwant Kurhe, Syam Nair, Marcus Ståhlman, Nagaraj M. Kulkarni, Jan Borén, Hanns‐Ulrich Marschall, Matthias Blüher, Margit Mahlapuu
Publikováno v:
Hepatology Communications, Vol 5, Iss 7, Pp 1183-1200 (2021)
Nonalcoholic fatty liver disease (NAFLD) has emerged as a leading cause of chronic liver disease worldwide, primarily because of the massive global increase in obesity. Despite intense research efforts in this field, the factors that govern the initi
Externí odkaz:
https://doaj.org/article/4e024d45939a4d848075e192c67e1a5a
Autor:
Sumit Kumar Anand, Mara Caputo, Ying Xia, Emma Andersson, Emmelie Cansby, Sima Kumari, Marcus Henricsson, Rando Porosk, Katharina Susanne Keuenhof, Johanna Louise Höög, Syam Nair, Hanns-Ulrich Marschall, Matthias Blüher, Margit Mahlapuu
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 7, Pp 100238- (2022)
The primary hepatic consequence of obesity is non-alcoholic fatty liver disease (NAFLD), affecting about 25% of the global adult population. Non-alcoholic steatohepatitis (NASH) is a severe form of NAFLD characterized by liver lipid accumulation, inf
Externí odkaz:
https://doaj.org/article/27fa9e174f6b494d9c0fcdb5a2bacb3c
Autor:
Annika Nerstedt, Yeshwant Kurhe, Emmelie Cansby, Mara Caputo, Lei Gao, Egor Vorontsov, Marcus Ståhlman, Esther Nuñez-Durán, Jan Borén, Hanns-Ulrich Marschall, Douglas G. Mashek, Darren N. Saunders, Carina Sihlbom, Andrew J. Hoy, Margit Mahlapuu
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 2, Pp 178-191 (2020)
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are emerging as leading causes of liver disease worldwide and have been recognized as one of the major unmet medical needs of the 21st century. Our recent translational
Externí odkaz:
https://doaj.org/article/5223ec8bf7604ecfadc7de925c7c5dab
Autor:
Ying Xia, Mara Caputo, Emmelie Cansby, Sumit Kumar Anand, Silva Sütt, Marcus Henricsson, Rando Porosk, Hanns-Ulrich Marschall, Matthias Blüher, Margit Mahlapuu
Publikováno v:
Molecular Metabolism, Vol 54, Iss , Pp 101353- (2021)
Objective: Nonalcoholic fatty liver disease (NAFLD), defined by excessive lipid storage in hepatocytes, has recently emerged as a leading global cause of chronic liver disease. The aim of this study was to examine the role of STE20-type protein kinas
Externí odkaz:
https://doaj.org/article/63503fb6b70f4a4db99a079b5a33ff2c
Autor:
Emmelie Cansby, Mara Caputo, Lei Gao, Nagaraj M. Kulkarni, Annika Nerstedt, Marcus Ståhlman, Jan Borén, Rando Porosk, Ursel Soomets, Matteo Pedrelli, Paolo Parini, Hanns-Ulrich Marschall, Jenny Nyström, Brian W. Howell, Margit Mahlapuu
Publikováno v:
JCI Insight, Vol 5, Iss 24 (2020)
Diabetic kidney disease (DKD) is the most common cause of severe renal disease worldwide and the single strongest predictor of mortality in diabetes patients. Kidney steatosis has emerged as a critical trigger in the pathogenesis of DKD; however, the
Externí odkaz:
https://doaj.org/article/76ee7c613d244adda29bbfe316fe4d15