Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Mar Rodríguez-Girondo"'
Autor:
Stephanie A. Schubert, Dina Ruano, Sebastien M. Joruiz, Jordy Stroosma, Nikolina Glavak, Anna Montali, Lia M. Pinto, Mar Rodríguez-Girondo, Daniela Q. C. M. Barge-Schaapveld, Maartje Nielsen, Bernadette P. M. van Nesselrooij, Arjen R. Mensenkamp, Monique E. van Leerdam, Thomas H. Sharp, Hans Morreau, Jean-Christophe Bourdon, Noel F. C. C. de Miranda, Tom van Wezel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Germline and somatic TP53 variants play a crucial role during tumorigenesis. However, genetic variations that solely affect the alternatively spliced p53 isoforms, p53β and p53γ, are not fully considered in the molecular diagnosis of Li-Fr
Externí odkaz:
https://doaj.org/article/56ab10ecaf2a481fbf606ffec4b57f89
Autor:
Marije H. Sluiskes, Jelle J. Goeman, Marian Beekman, P. Eline Slagboom, Hein Putter, Mar Rodríguez-Girondo
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background There is divergence in the rate at which people age. The concept of biological age is postulated to capture this variability, and hence to better represent an individual’s true global physiological state than chronological age.
Externí odkaz:
https://doaj.org/article/786492533f114367a8d0041a7311830a
Autor:
María Gallardo-Gómez, Mar Rodríguez-Girondo, Núria Planell, Sebastian Moran, Luis Bujanda, Ane Etxart, Antoni Castells, Francesc Balaguer, Rodrigo Jover, Manel Esteller, Joaquín Cubiella, David Gómez-Cabrero, Loretta De Chiara
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-17 (2023)
Abstract Background Early detection has proven to be the most effective strategy to reduce the incidence and mortality of colorectal cancer (CRC). Nevertheless, most current screening programs suffer from low participation rates. A blood test may imp
Externí odkaz:
https://doaj.org/article/30aa5504516a4b318ec2757d888d1389
Autor:
Niels van den Berg, Mar Rodríguez-Girondo, Ingrid K. van Dijk, P. Eline Slagboom, Marian Beekman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Globally, the lifespan of populations increases but the healthspan is lagging behind. Previous research showed that survival into extreme ages (longevity) clusters in families as illustrated by the increasing lifespan of study participants w
Externí odkaz:
https://doaj.org/article/766a9773f5514a0f9bf0ddc49e70d005
Publikováno v:
BMC Medical Research Methodology, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background Although human longevity tends to cluster within families, genetic studies on longevity have had limited success in identifying longevity loci. One of the main causes of this limited success is the selection of participants. Studi
Externí odkaz:
https://doaj.org/article/4830dee42cba4b55871e1f5e341e92f8
Autor:
Niels van den Berg, Mar Rodríguez-Girondo, Ingrid K. van Dijk, Rick J. Mourits, Kees Mandemakers, Angelique A. P. O. Janssens, Marian Beekman, Ken R. Smith, P. Eline Slagboom
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
While human lifespan is only moderately heritable, “getting old” runs in families. Here, van den Berg et al. study mortality data from three-generation cohorts to define a threshold for longevity and find that individuals have an increasing survi
Externí odkaz:
https://doaj.org/article/44642dfb9cb94830b8332d5e5db86fc0
Autor:
María Gallardo-Gómez, Sebastian Moran, María Páez de la Cadena, Vicenta Soledad Martínez-Zorzano, Francisco Javier Rodríguez-Berrocal, Mar Rodríguez-Girondo, Manel Esteller, Joaquín Cubiella, Luis Bujanda, Antoni Castells, Francesc Balaguer, Rodrigo Jover, Loretta De Chiara
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-10 (2018)
Abstract Background Colorectal cancer is the fourth cause of cancer-related deaths worldwide, though detection at early stages associates with good prognosis. Thus, there is a clear demand for novel non-invasive tests for the early detection of color
Externí odkaz:
https://doaj.org/article/91b0328e34974e03be11e529d81848f6
Autor:
Loretta De Chiara, Virginia Leiro-Fernandez, Mar Rodríguez-Girondo, Diana Valverde, María Isabel Botana-Rial, Alberto Fernández-Villar
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9242 (2020)
Different methodological approaches are available to assess DNA methylation biomarkers. In this study, we evaluated two sodium bisulfite conversion-dependent methods, namely pyrosequencing and methylation-specific qPCR (MS-qPCR), with the aim of meas
Externí odkaz:
https://doaj.org/article/ec2ba2cabbaf47fa9f4a3137f963df0e
Improving stability of prediction models based on correlated omics data by using network approaches.
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192853 (2018)
Building prediction models based on complex omics datasets such as transcriptomics, proteomics, metabolomics remains a challenge in bioinformatics and biostatistics. Regularized regression techniques are typically used to deal with the high dimension
Externí odkaz:
https://doaj.org/article/42f50a69fe984d24b08304eab5fec140
Autor:
Sonia Blanco-Prieto, Lorena Vázquez-Iglesias, Mar Rodríguez-Girondo, Leticia Barcia-Castro, Alberto Fernández-Villar, María Isabel Botana-Rial, Francisco Javier Rodríguez-Berrocal, María Páez de la Cadena
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127318 (2015)
Lung cancer is the most lethal neoplasia, and an early diagnosis is the best way for improving survival. Symptomatic patients attending Pulmonary Services could be diagnosed with lung cancer earlier if high-risk individuals are promptly separated fro
Externí odkaz:
https://doaj.org/article/c3f3642c891b44c2adef3b2400b8d09e