HIV and mature dendritic cells: Trojan exosomes riding the Trojan horse?

Autor: Nuria Izquierdo-Useros, Mar Naranjo-Gómez, Itziar Erkizia, Maria Carmen Puertas, Francesc E Borràs, Julià Blanco, Javier Martinez-Picado

Publikováno v: PLoS Pathogens, Vol 6, Iss 3, p e1000740 (2010)

Exosomes are secreted cellular vesicles that can induce specific CD4(+) T cell responses in vivo when they interact with competent antigen-presenting cells like mature dendritic cells (mDCs). The Trojan exosome hypothesis proposes that retroviruses c

Externí odkaz: https://doaj.org/article/44b7853429764e1390f264bef1ff14e5

Comparative transcriptomic profile of tolerogenic dendritic cells differentiated with vitamin D3, dexamethasone and rapamycin

Autor: Alex Sánchez-Pla, Eva Martínez-Cáceres, Cristina Ramo-Tello, Aina Teniente-Serra, Juan Navarro-Barriuso, María José Mansilla, Bibiana Quirant-Sánchez, Mar Naranjo-Gómez

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Scientific Reports
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)

Tolerogenic dendritic cell (tolDC)-based therapies have become a promising approach for the treatment of autoimmune diseases by their potential ability to restore immune tolerance in an antigen-specific manner. However, the broad variety of protocols

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0276d9afb303eba5291c3741ae9fc732
https://ddd.uab.cat/record/253670

Capture of cell-derived microvesicles (exosomes and apoptotic bodies) by human plasmacytoid dendritic cells

Autor: Mar Naranjo-Gómez, Ricardo Pujol-Borrell, Patricia Bastos-Amador, Nuria Izquierdo-Useros, Maria C. Puertas, Begoña Pérez-Cabezas, Javier Martinez-Picado, Francesc E. Borràs

Publikováno v: Journal of Leukocyte Biology. 91:751-758

cDCs and pDCs differ in multiple aspects. Among those, antigen capture is a recognized feature of cDCs, whereas pDCs display poor capacity to capture cell-derived antigens. However, animal models of organ transplantation suggested a role for pDCs in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eda2c16658d761b53f46dab728d93f8
https://doi.org/10.1189/jlb.0111054

Ligation of Notch Receptors in Human Conventional and Plasmacytoid Dendritic Cells Differentially Regulates Cytokine and Chemokine Secretion and Modulates Th Cell Polarization

Autor: Mar Naranjo-Gómez, Francesc E. Borràs, Ricardo Pujol-Borrell, Gerard Requena-Fernández, Begoña Pérez-Cabezas, Patricia Bastos-Amador

Publikováno v: Universitat Autònoma de Barcelona

Notch signaling is involved in multiple cellular processes. Recent data also support the prominent role of Notch signaling in the regulation of the immune response. In this study, we analyzed the expression and function of Notch receptors and ligands

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba39ed0e7fa2408e8f2385569f3adde1
https://doi.org/10.4049/jimmunol.1100203

Maturation of Blood-Derived Dendritic Cells Enhances Human Immunodeficiency Virus Type 1 Capture and Transmission

Autor: Lidia Ruiz, María Teresa Fernández-Figueras, Mar Naranjo-Gómez, Bonaventura Clotet, Julià Blanco, Margarita Bofill, Nuria Izquierdo-Useros, Francesc E. Borràs, Javier Martinez-Picado, Itziar Erkizia

Publikováno v: Journal of Virology. 81:7559-7570

Dendritic cells (DCs) are specialized antigen-presenting cells. However, DCs exposed to human immunodeficiency virus type 1 (HIV-1) are also able to transmit a vigorous cytopathic infection to CD4 + T cells, a process that has been frequently related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c3e0050a694a01efd2e1affe596684
https://doi.org/10.1128/jvi.02572-06