Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Mar Jimenez Quesada"'
Autor:
Mar Jimenez Quesada, Ellen Catherine Macdonald, Allan M. Jordan, Caroline Foxton, Huib Ovaa, Pritom Shah, Elisabeth Trivier, Aurore Lejeune, Tony Raynham, Wouter H. Moolenaar, Muddasar Farooq, Martin Stockley, P.J. Owen, James R. Hitchin, Jana Skeete, Michelle Pritchard, Irene Farre Gutierrez, Hamish Ryder, Niall M. Hamilton, Andrew P. Turnbull, Anne Cheasty, Leon Pang, Alexandra Stowell, Susan M. Boyd
Publikováno v:
Bioorganic and Medicinal Chemistry Letters, 26(22), 5403-5410
The autotaxin-lysophosphatidic acid (ATX-LPA) axis has been implicated in several disease conditions including inflammation, fibrosis and cancer. This makes ATX an attractive drug target and its inhibition may lead to useful therapeutic agents. Throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7b70a8962d8c311e0ac46deffdc0f8
https://hdl.handle.net/1887/111844
https://hdl.handle.net/1887/111844
Autor:
Stephanie Maine, Niall M. B. Martin, Marc Geoffrey Hummersone, Carrie-Anne Molyneaux, Christine Bailey, Sharon Maguire, Frederic Georges Marie Leroux, Hermann Gesine Johanna, Graeme C. M. Smith, Ian Hickson, Mar Jimenez Quesada, James R. Pullen, Heather Mary Ellen Duggan, Keith Allan Menear, Peter D. Edwards, Martin Pass, Sylvie Gomez, Lisa Smith, Jan Drzewiecki, Karine Malagu, Armelle Le Gall
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(20)
We describe a novel series of potent inhibitors of the kinase activity of mTOR. The compounds display good selectivity relative to other PI3K-related kinase family members and, in cellular assays, inhibit both mTORC1 and mTORC2 complexes and exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e97b020323b939309b4dfc7c6e5fdc
https://pubmed.ncbi.nlm.nih.gov/19762236
https://pubmed.ncbi.nlm.nih.gov/19762236
