Výsledky vyhledávání - "Marı́a Luisa C. Vale"

Modeling of ultra-small lipid nanoparticle surface charge for targeting glioblastoma

Autor: Tânia F.G.G. Cova, João Sousa, Carla Vitorino, Marı́a Luisa C. Vale, Lídia Gonçalves, Ana Miranda, Alberto A. C. C. Pais, António J. Almeida, Eduardo F. Marques, Maria Mendes

Publikováno v: European Journal of Pharmaceutical Sciences. 117:255-269

Surface modification of ultra-small nanostructured lipid carriers (usNLC) via introduction of a positive charge is hypothesized to prompt site-specific drug delivery for glioblastoma multiforme (GBM) treatment. A more effective interaction with negat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c651adcdc79edd95879aef0102f52ee
https://doi.org/10.1016/j.ejps.2018.02.024

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Enhancing glioblastoma cell sensitivity to chemotherapeutics: A strategy involving survivin gene silencing mediated by gemini surfactant-based complexes

Autor: Eduardo F. Marques, Catarina M. Morais, Marı́a Luisa C. Vale, Maria C. Pedroso de Lima, A. Rita Cruz, Sandra G. Silva, Amália S. Jurado, Ana M. Cardoso

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics. 104:7-18

Glioblastoma (GBM), the highest grade astrocytoma, is one of the most aggressive and challenging cancers to treat. The standard treatment is usually limited due to the intrinsic resistance of GBM to chemotherapy and drug non-specific effects. Therefo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886bae8d2ec8757159438f22a94bd900
https://doi.org/10.1016/j.ejpb.2016.04.014

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Synthesis of Polyhydroxylated Pyrrolidines and Aziridinopyrrolidines from [4π+2π] Cycloadducts of Cyclopentadiene and Imines/2H-Azirines

Autor: Maria J. Alves, Marı́a Luisa C. Vale, Fabio Rizzo Aguiar, Xerardo García-Mera, José E. Rodríguez-Borges

Publikováno v: Synthesis. 2008:971-977

The synthesis of 2-functionalized 3,5-bis(hydroxymethyl)pyrrolidines from readily available polycyclic Diels-Alder adducts by a reaction sequence involving three steps is described. The same methodology has been applied to obtain the aziridine counte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04c9e9bb606f99304314ff8d8a675887
https://doi.org/10.1055/s-2008-1032196

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The use of (−)-8-phenylisoneomenthol and (−)-8-phenylmenthol in the enantioselective synthesis of 3-functionalized 2-azabicyclo[2.2.1]heptane derivatives via aza-Diels–Alder reaction

Autor: Franco Fernández, Xerardo García-Mera, José E. Rodríguez-Borges, Olga Caamaño, Marı́a Luisa C. Vale

Publikováno v: Tetrahedron. 62:9475-9482

The asymmetric aza-Diels–Alder reaction of the (1R)-8-phenylmenthyl or (1R)-8-phenylisoneomenthyl glyoxylate-derived N-benzylimine with cyclopentadiene resulted in the enantioselective synthesis of the corresponding pure [(1S,3-exo)-2-benzyl-2-azab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c37d2692b4da923891be0ffad8507ae
https://doi.org/10.1016/j.tet.2006.06.118

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Enantioselective Synthesis of [(1R,3-exo)-2-Benzyl-2-azabicyclo[2.2.1]hept-5-en-3-yl]methanol via Aza-Diels-Alder Reaction

Autor: Marı́a Luisa C. Vale, Xerardo García-Mera, Franco Fernández, José E. Rodríguez-Borges

Publikováno v: Synlett. :319-321

The asymmetric aza-Diels-Alder reaction of the 8-phenylneomenthyl (or 8-phenylisomenthyl) glyoxylate-derived N-benzylimine with cyclopentadiene resulted in the enantioselective synthesis of the corresponding [(1R,3-exo))-2-benzyl-2-azabicyclo[2.2.1]h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cdcdb0231adf0901bc267a2178b3d56c
https://doi.org/10.1055/s-2004-836068

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The exo-selectivity of the new non-natural chiral auxiliary (+)-(1R,endo)-2-benzonorbornenol in an asymmetric aza-Diels–Alder reaction

Autor: José E. Rodríguez-Borges, Xerardo García-Mera, Marı́a Luisa C. Vale, Franco Fernández

Publikováno v: Tetrahedron Letters. 44:431-433

The recently reported compound (+)-(1 R , endo )-2-benzonorbornenol ( 2 ) proved to be an efficient chiral auxiliary in the asymmetric aza-Diels–Alder reaction between cyclopentadiene and the N -benzyl imine of its glyoxylate, which afforded a virt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b74f5139e7cc89005e567c79654295dd
https://doi.org/10.1016/s0040-4039(02)02599-6

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Enhanced interfacial properties of novel amino acid-derived surfactants: Effects of headgroup chemistry and of alkyl chain length and unsaturation

Autor: José Enrique-Borges, Eduardo F. Marques, Rodrigo O. Brito, Sandra G. Silva, Marı́a Luisa C. Vale, Ricardo M.F. Fernandes

Publikováno v: Colloids and surfaces. B, Biointerfaces. 86(1)

Amino acid-derived surfactants have increasingly become a viable biofriendly alternative to petrochemically based amphiphiles as speciality surfactants. Herein, the Krafft temperatures and critical micelle concentrations (cmc) of three series of nove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb181354e55f3ea007301ad739fcfab
https://pubmed.ncbi.nlm.nih.gov/21493048

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Methyl 2-diphenylphosphoryloxy-2-azabicyclo[2.2.1]hept-5-ene-3-exo-carboxylate

Autor: José E. Rodríguez-Borges, Xerardo García-Mera, Carlos Sousa, Marı́a Luisa C. Vale

Publikováno v: Acta Crystallographica Section E, Vol 65, Iss 1, Pp o188-o188 (2009)
Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela
Universidad de Santiago de Compostela (USC)
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname
Acta Crystallographica Section E: Structure Reports

In the title compound, C20H20NO4P, the dihedral angle between the phenyl rings is 68.52 (7) . In the crystal structure, the molecules are linked by a weak C—H(arene) interaction along [010] involving the phenyl CH group and the phenyl rings. There

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3638c619cc281202d5f89b90dfabb53
http://scripts.iucr.org/cgi-bin/paper?S160053680804292X

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(1RS,4RS,5RS)-Methyl 2-(3,5-dinitrobenzoyl)-2-oxa-3-azabicyclo[3.3.0]oct-7-ene-4-carboxylate

Autor: Marı́a Luisa C. Vale, Xerardo García-Mera, Carlos Sousa, José E. Rodríguez-Borges

Publikováno v: Acta Crystallographica Section E, Vol 65, Iss 5, Pp o992-o993 (2009)
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname
Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela
Universidad de Santiago de Compostela (USC)
Acta Crystallographica Section E: Structure Reports

In organic synthesis, the usual techniques as NMR, mass or infra-red spectrometry and elemental analysis are often not enough for the unequivocally determination of a structure of a compound. When it is possible to crystallize desired compound, the X

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920d13d837398285446e16cb4b2ce465
https://doi.org/10.1107/s160053680901246x

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