Efficacy of ceftazidime-avibactam in solid organ transplant recipients with bloodstream infections caused by carbapenemase-producing Klebsiella pneumoniae.

Autor: Pérez-Nadales E; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Spanish Network for Research in Infectious Diseases (REIPI), Instituto de Salud Carlos III, Madrid, Spain; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Reina Sofía University Hospital, Cordoba, Spain; Department of Agricultural Chemistry, Soil Science and Microbiology, University of Cordoba, Cordoba, Spain. Electronic address: elena.pereznadales@imibic.org., Fernández-Ruiz M; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Spanish Network for Research in Infectious Diseases (REIPI), Instituto de Salud Carlos III, Madrid, Spain; Unit of Infectious Diseases, '12 de Octubre' University Hospital, Instituto de Investigación Hospital '12 de Octubre' (imas12), Universidad Complutense, Madrid, Spain., Natera AM; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Spanish Network for Research in Infectious Diseases (REIPI), Instituto de Salud Carlos III, Madrid, Spain; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Reina Sofía University Hospital, Cordoba, Spain., Gutiérrez-Gutiérrez B; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Spanish Network for Research in Infectious Diseases (REIPI), Instituto de Salud Carlos III, Madrid, Spain; Clinical Unit of Infectious Diseases and Microbiology, University Hospital Virgen Macarena, and Department of Medicine and Microbiology, University of Seville, Institute of Biomedicine of Seville (University Hospital Virgen Macarena/CSIC/University of Seville), Seville, Spain., Mularoni A; Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione (IRCCS-ISMETT), Palermo, Italy., Russelli G; Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione (IRCCS-ISMETT), Palermo, Italy., Pierrotti LC; Department of Infectious Diseases, University of São Paulo School of Medicine Hospital das Clínicas, São Paulo, Brazil., Pinheiro Freire M; Working Committee for Hospital Epidemiology and Infection Control, University of São Paulo School of Medicine Hospital das Clínicas, São Paulo, Brazil., Falcone M; Department of Clinical and Experimental Medicine, Infectious Diseases Unit, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Italy., Tiseo G; Department of Clinical and Experimental Medicine, Infectious Diseases Unit, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Italy., Tumbarello M; Dipartimento Biotecnologie Mediche, Università di Siena, Siena, Italy., Raffaelli F; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Abdala E; Faculdade de Medicina da Universidade de Sao Paulo, Instituto do Cancer do Estado de Sao Paulo, Brazil., Bodro M; Department of Infectious Diseases, Hospital Clinic - IDIBAPS, University of Barcelona, Barcelona, Spain., Gervasi E; Infectious Diseases Unit, Papa Giovanni XXIII Hospital, Bergamo, Italy., Fariñas MC; Department of Infectious Diseases, Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain., Seminari EM; Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Castón JJ; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Spanish Network for Research in Infectious Diseases (REIPI), Instituto de Salud Carlos III, Madrid, Spain; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Reina Sofía University Hospital, Cordoba, Spain; Clinical Unit of Infectious Diseases, Reina Sofía University Hospital, Cordoba, Spain., Marín-Sanz JA; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Reina Sofía University Hospital, Cordoba, Spain., Gálvez-Soto V; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Reina Sofía University Hospital, Cordoba, Spain., Rana MM; Icahn School of Medicine at Mount Sinai, New York, New York, USA., Loeches B; Clinical Unit of Infectious Diseases, La Paz University Hospital, Madrid, Spain., Martín-Dávila P; Department of Infectious Diseases, Ramón y Cajal University Hospital, Madrid, Spain., Pascual Á; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Spanish Network for Research in Infectious Diseases (REIPI), Instituto de Salud Carlos III, Madrid, Spain; Clinical Unit of Infectious Diseases and Microbiology, University Hospital Virgen Macarena, and Department of Medicine and Microbiology, University of Seville, Institute of Biomedicine of Seville (University Hospital Virgen Macarena/CSIC/University of Seville), Seville, Spain., Rodríguez-Baño J; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Spanish Network for Research in Infectious Diseases (REIPI), Instituto de Salud Carlos III, Madrid, Spain; Clinical Unit of Infectious Diseases and Microbiology, University Hospital Virgen Macarena, and Department of Medicine and Microbiology, University of Seville, Institute of Biomedicine of Seville (University Hospital Virgen Macarena/CSIC/University of Seville), Seville, Spain., Aguado JM; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Spanish Network for Research in Infectious Diseases (REIPI), Instituto de Salud Carlos III, Madrid, Spain; Unit of Infectious Diseases, '12 de Octubre' University Hospital, Instituto de Investigación Hospital '12 de Octubre' (imas12), Universidad Complutense, Madrid, Spain., Martínez-Martínez L; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Spanish Network for Research in Infectious Diseases (REIPI), Instituto de Salud Carlos III, Madrid, Spain; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Reina Sofía University Hospital, Cordoba, Spain; Department of Agricultural Chemistry, Soil Science and Microbiology, University of Cordoba, Cordoba, Spain; Clinical Unit of Microbiology, Reina Sofía University Hospital, Cordoba, Spain., Torre-Cisneros J; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Spanish Network for Research in Infectious Diseases (REIPI), Instituto de Salud Carlos III, Madrid, Spain; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Reina Sofía University Hospital, Cordoba, Spain; Department of Medical and Surgical Sciences, University of Cordoba, Cordoba, Spain; Clinical Unit of Infectious Diseases, Reina Sofía University Hospital, Cordoba, Spain.

Publikováno v: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2023 Jul; Vol. 23 (7), pp. 1022-1034. Date of Electronic Publication: 2023 Apr 05.

Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug.

Autor: Alors-Perez E; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Córdoba, Spain.; Reina Sofia University Hospital, Córdoba, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Avenida Menéndez Pidal s/n, Edificio IMIBIC, 14004, Córdoba, Spain., Blázquez-Encinas R; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Córdoba, Spain.; Reina Sofia University Hospital, Córdoba, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Avenida Menéndez Pidal s/n, Edificio IMIBIC, 14004, Córdoba, Spain., Alcalá S; Department of Biochemistry, Universidad Autónoma de Madrid (UAM) and Department of Cancer Biology, Instituto de Investigaciones Biomédicas Alberto Sols (IIBM), CSIC-UAM, Madrid, Spain.; Department of Cancer Biology, Chronic Diseases and Cancer Area 3-Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain., Viyuela-García C; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain.; Reina Sofia University Hospital, Córdoba, Spain.; Surgery Service, Reina Sofia University Hospital, Córdoba, Spain., Pedraza-Arevalo S; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Córdoba, Spain.; Reina Sofia University Hospital, Córdoba, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Avenida Menéndez Pidal s/n, Edificio IMIBIC, 14004, Córdoba, Spain., Herrero-Aguayo V; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Córdoba, Spain.; Reina Sofia University Hospital, Córdoba, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Avenida Menéndez Pidal s/n, Edificio IMIBIC, 14004, Córdoba, Spain., Jiménez-Vacas JM; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Córdoba, Spain.; Reina Sofia University Hospital, Córdoba, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Avenida Menéndez Pidal s/n, Edificio IMIBIC, 14004, Córdoba, Spain., Mafficini A; ARC-Net Research Centre, University and Hospital Trust of Verona, Verona, Italy., Sánchez-Frías ME; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain.; Reina Sofia University Hospital, Córdoba, Spain.; Pathology Service, Reina Sofia University Hospital, Córdoba, Spain., Cano MT; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain.; Reina Sofia University Hospital, Córdoba, Spain.; Medical Oncology Service, Reina Sofia University Hospital, Córdoba, Spain., Abollo-Jiménez F; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain.; Department of Computer Sciences, University of Cordoba, Córdoba, Spain., Marín-Sanz JA; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain.; Department of Computer Sciences, University of Cordoba, Córdoba, Spain., Cabezas-Sainz P; Department of Zoology, Genetics and Physical Anthropology, University of Santiago de Compostela, Lugo, Spain., Lawlor RT; ARC-Net Research Centre, University and Hospital Trust of Verona, Verona, Italy., Luchini C; ARC-Net Research Centre, University and Hospital Trust of Verona, Verona, Italy.; Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy., Sánchez L; Department of Zoology, Genetics and Physical Anthropology, University of Santiago de Compostela, Lugo, Spain., Sánchez-Hidalgo JM; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain.; Reina Sofia University Hospital, Córdoba, Spain.; Surgery Service, Reina Sofia University Hospital, Córdoba, Spain., Ventura S; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain.; Department of Computer Sciences, University of Cordoba, Córdoba, Spain., Martin-Hijano L; Department of Biochemistry, Universidad Autónoma de Madrid (UAM) and Department of Cancer Biology, Instituto de Investigaciones Biomédicas Alberto Sols (IIBM), CSIC-UAM, Madrid, Spain.; Department of Cancer Biology, Chronic Diseases and Cancer Area 3-Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain., Gahete MD; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Córdoba, Spain.; Reina Sofia University Hospital, Córdoba, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Avenida Menéndez Pidal s/n, Edificio IMIBIC, 14004, Córdoba, Spain., Scarpa A; ARC-Net Research Centre, University and Hospital Trust of Verona, Verona, Italy.; Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy., Arjona-Sánchez Á; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain.; Reina Sofia University Hospital, Córdoba, Spain.; Surgery Service, Reina Sofia University Hospital, Córdoba, Spain., Ibáñez-Costa A; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Córdoba, Spain.; Reina Sofia University Hospital, Córdoba, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Avenida Menéndez Pidal s/n, Edificio IMIBIC, 14004, Córdoba, Spain., Sainz B Jr; Department of Biochemistry, Universidad Autónoma de Madrid (UAM) and Department of Cancer Biology, Instituto de Investigaciones Biomédicas Alberto Sols (IIBM), CSIC-UAM, Madrid, Spain. bsainz@iib.uam.es.; Centro de Investigación Biomédica en Red, Área Cáncer, CIBERONC, ISCIII, Madrid, Spain. bsainz@iib.uam.es., Luque RM; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain. raul.luque@uco.es.; Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Córdoba, Spain. raul.luque@uco.es.; Reina Sofia University Hospital, Córdoba, Spain. raul.luque@uco.es.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Avenida Menéndez Pidal s/n, Edificio IMIBIC, 14004, Córdoba, Spain. raul.luque@uco.es., Castaño JP; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain. justo@uco.es.; Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Córdoba, Spain. justo@uco.es.; Reina Sofia University Hospital, Córdoba, Spain. justo@uco.es.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Avenida Menéndez Pidal s/n, Edificio IMIBIC, 14004, Córdoba, Spain. justo@uco.es.

Publikováno v: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2021 Dec 02; Vol. 40 (1), pp. 382. Date of Electronic Publication: 2021 Dec 02.