Divergent CPEB prion-like domains reveal different assembly mechanisms for a generic amyloid-like fold

Autor: Rubén Hervás, María del Carmen Fernández-Ramírez, Albert Galera-Prat, Mari Suzuki, Yoshitaka Nagai, Marta Bruix, Margarita Menéndez, Douglas V. Laurents, Mariano Carrión-Vázquez

Publikováno v: BMC Biology, Vol 19, Iss 1, Pp 1-14 (2021)

Abstract Background Amyloids are ordered, insoluble protein aggregates, characterized by a cross-β sheet quaternary structure in which molecules in a β-strand conformation are stacked along the filament axis via intermolecular interactions. While a

Externí odkaz: https://doaj.org/article/424f921c44eb4d14bf0ae0e29dc08050

Expanded Conformations of Monomeric Tau Initiate Its Amyloidogenesis

Autor: María del Carmen Fernández‐Ramírez, Kevin Kan‐Shing Ng, Margarita Menéndez, Douglas V. Laurents, Rubén Hervás, Mariano Carrión‐Vázquez

Publikováno v: Angewandte Chemie (International ed. in English).

11 pags., 5 figs.
Understanding early amyloidogenesis is key to rationally develop therapeutic strategies. Tau protein forms well-characterized pathological deposits but its aggregation mechanism is still poorly understood. Using single-molecule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec41f38ddd764f706719f308e941755
https://pubmed.ncbi.nlm.nih.gov/36542681

Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy

Autor: Binh An Nguyen, Virender Singh, Shumaila Afrin, Anna Yakubovska, Lanie Wang, Yasmin Ahmed, Rose Pedretti, Maria del Carmen Fernandez-Ramirez, Preeti Singh, Maja Pękała, Luis O. Cabrera Hernandez, Siddharth Kumar, Andrew Lemoff, Roman Gonzalez-Prieto, Michael R. Sawaya, David S. Eisenberg, Merrill Douglas Benson, Lorena Saelices

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract ATTR amyloidosis is caused by the deposition of transthyretin in the form of amyloid fibrils in virtually every organ of the body, including the heart. This systemic deposition leads to a phenotypic variability that has not been molecularly

Externí odkaz: https://doaj.org/article/60a20b40007f4acdaf11442427648360

Molecular mechanism of the inhibition of TDP-43 amyloidogenesis by QBP1

Autor: Daniel Ramírez de Mingo, Douglas V. Laurents, María del Carmen Fernández-Ramírez, Rubén Hervás, Mariano Carrión-Vázquez, Miguel Mompeán

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Transactive Response DNA-Binding Protein of 43 kDa (TDP-43) is an essential human protein implicated in Amyotrophic Lateral Sclerosis (ALS) and common dementias. Its C-terminal disordered region, composed of residues 264–414 includes a hydrophobic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540aebb92fcbe1aaa1f4fc5e56954568
http://hdl.handle.net/10261/206121

Contributors

Autor: Marie-Isabel Aguilar, Maria Andreasen, Neil R. Anthony, Fernando Teran Arce, Florian Arnhold, Shruti Arya, Aida Attar, Silvia Barbosa, Manja A. Behrens, Innocent B. Bekard, Georges Belfort, Martin L. Bennink, Magdalena Bereza, Keith M. Berland, Gal Bitan, Mischa Bonn, Hugo M. Botelho, Joana Branco dos Santos, Leonid Breydo, Yi Cao, Roberto Cappai, Isabel Cardoso, Mariano Carrión-Vázquez, Sofia B. Carvalho, John A. Carver, Fiona T.S. Chan, W. Seth Childers, Jason C. Collins, Laura Connelly, Cyril Curtain, Vijit Dalal, Alfonso De Simone, Athene M. Donald, Dave E. Dunstan, Heath Ecroyd, Jan Johannes Enghild, Laura Esther Abelleira, Marcus Fändrich, María del Carmen Fernández-Ramírez, Vito Foderà, Günter Fritz, Yoshiaki Furukawa, Shirin D. Ghodke, Stefano Gianni, Armin Giese, Cláudio M. Gomes, Susana Gonçalves, Lesley H. Greene, Michael D.W. Griffin, Amy M. Griggs, Christian Haass, Per Hammarström, J. Robin Harris, Federico Herrera, Rubén Hervás, Shannon E. Hill, Xu Hou, Geoffrey J. Howlett, Tsuneya Ikezu, Hyunbum Jang, Grethe V. Jensen, Bruce L. Kagan, Clemens F. Kaminski, Shigeko Kawai-Noma, Alexei Klechikov, Gijsje H. Koenderink, Ratnesh Lal, Douglas V. Laurents, Chi Le Lan Pham, Harry LeVine, Dusan Losic, David G. Lynn, Kirsten G. Malmos, Lisandra L. Martin, Adam I. Mechler, Anil K. Mehta, Derya Meral, Nathaniel G.N. Milton, Yee-Foong Mok, Ludmilla A. Morozova-Roche, Víctor Mosquera, Samrat Mukhopadhyay, Mentor Mulaj, Martin Muschol, Niels Chr Nielsen, R. Nilsson, Georg Nübling, Ruth Nussinov, Daniel E. Otzen, Tiago Fleming Outeiro, Jan Skov Pedersen, Jesper Søndergaard Pedersen, K. Peter, Dorothea Pinotsi, Meng Qin, Srinivasan Ramachandran, Agata Rekas, Annalisa Relini, Jean-Christophe Rochet, Sophie Rothhämel, Nikita Rudinskiy, Markus Sauer, Gabriele S. Kaminski Schierle, Michael Schleeger, Bettina Schmid, David H. Small, Anne Søndergaard, Mirco Sorci, Tara L. Spires-Jones, Marcel Stenvang, Martin Stöckl, Katrin Strecker, Vinod Subramaniam, Anna S.P. Svane, Kim K.M. Sweers, Pablo Taboada, Hideki Taguchi, Chai Lean Teoh, David C. Thorn, Kiyotaka Tokuraku, Robert Tycko, Brigita Urbanc, Vladimir N. Uversky, Corianne C. van den Akker, Michele Vendruscolo, Anna von Mikecz, Vladana Vukojević, Wei Wang, Katrin Weise, Roland Winter, Jessica W. Wu, Wei-Feng Xue, Kiran Yanamandra, Daniel Ysselstein, Eva Žerovnik, Dawei Zou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c175a1f0ef43b7e6a7630800263015e
https://doi.org/10.1016/b978-0-12-394431-3.01002-6