D- and N-Methyl Amino Acids for Modulating the Therapeutic Properties of Antimicrobial Peptides and Lipopeptides

Autor: Maria Veronica Humpola, Roque Spinelli, Melina Erben, Virginia Perdomo, Georgina Guadalupe Tonarelli, Fernando Albericio, Alvaro Sebastian Siano

Publikováno v: Antibiotics, Vol 12, Iss 5, p 821 (2023)

Here we designed and synthesized analogs of two antimicrobial peptides, namely C10:0-A2, a lipopeptide, and TA4, a cationic α-helical amphipathic peptide, and used non-proteinogenic amino acids to improve their therapeutic properties. The physicoche

Externí odkaz: https://doaj.org/article/376bac28dc784c9d94650948d48f9dbd

A Comparative Study of the Antimicrobial and Structural Properties of Short Peptides and Lipopeptides Containing a Repetitive Motif KLFK

Autor: Georgina Tonarelli, María Verónica Húmpola, Arturo Carlos Simonetta, María Carolina Rey, Pablo Gabriel Spontón

Publikováno v: Protein & Peptide Letters. 26:192-203

Background:In the last years, Antimicrobial Peptides (AMPs) and lipopeptides have received attention as promising candidates to treat infections caused by resistant microorganisms. Objective: The main objective of this study was to investigate the ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faeea1c16136100fbddf7c03e3ac3831
https://doi.org/10.2174/0929866526666181208144629

Leptodactylus latrans Amphibian Skin Secretions as a Novel Source for the Isolation of Antibacterial Peptides

Autor: Georgina Tonarelli, Fernando Albericio, Eliandre de Oliveira, María Verónica Húmpola, Rafael Carlos Lajmanovich, Alvaro Sebastían Siano, Arturo Carlos Simonetta

Publikováno v: Molecules
Volume 23
Issue 11
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Molecules, Vol 23, Iss 11, p 2943 (2018)

Amphibians´
skin produces a diverse array of antimicrobial peptides that play a crucial role as the first line of defense against microbial invasion. Despite the immense richness of wild amphibians in Argentina, current knowledge about the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569633d2d6a9009358c327acf51355d7
http://europepmc.org/articles/PMC6278411

Interaction of Acylated and Substituted Antimicrobial Peptide Analogs with Phospholipid-Polydiacetylene Vesicles. Correlation with their Biological Properties

Autor: María Carolina Rey, Arturo Carlos Simonetta, Georgina Tonarelli, María Verónica Húmpola, Alvaro Sebastían Siano

Publikováno v: Chemical Biology & Drug Design. 78:85-93

A series of peptide analogs based on region 6-22 of Plantaricin 149 sequence were synthesized. The interaction between these analogs and phospholipid-polydiacetylene vesicles was investigated to evaluate the ability of the bioassay to detect differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab38190658183c0f2c56c9ba27d18b24
https://doi.org/10.1111/j.1747-0285.2011.01099.x

Antimicrobial Peptides from Skin Secretions of Hypsiboas pulchellus (Anura: Hylidae)

Autor: Georgina Tonarelli, Fernando Albericio, Alvaro Sebastían Siano, Eliandre de Oliveira, Arturo Carlos Simonetta, María Verónica Húmpola, Rafael Carlos Lajmanovich

The skin of many amphibians produces a large repertoire of antimicrobial peptides that are crucial in the first line of defense against microbial invasion. Despite the immense richness of wild amphibians in Argentina, knowledge about peptides with an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154e07bbd9645c5674d67f6237eab2a0
http://pubs.acs.org/doi/abs/10.1021/np4009317