Výsledky vyhledávání - "María V. Ruiz-Armenta"

Inflammatory and fibrotic processes are involved in the cardiotoxic effect of sunitinib: Protective role of l -carnitine

Autor: Sonia Zambrano, Carmen Vázquez, José L. Miguel-Carrasco, José L. Arias, Oscar Aramburu, Alfonso Mate, Miguel Arévalo, Antonio J. Blanca, María V. Ruiz-Armenta

Publikováno v: Toxicology Letters. 241:9-18

Sunitinib (Su) is currently approved for treatment of several malignances. However, along with the benefits of disease stabilization, cardiovascular toxicities have also been increasingly recognized. The aim of this study was to analyze which mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac39806618d2daa05977f67ec442fb1
https://doi.org/10.1016/j.toxlet.2015.11.007

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The renoprotective effect of l-carnitine in hypertensive rats is mediated by modulation of oxidative stress-related gene expression

Autor: Elisa Revilla, Sonia Zambrano, María V. Ruiz-Armenta, Carmen Vázquez, Antonio J. Blanca, José L. Miguel-Carrasco, Alfonso Mate, Consuelo Santa-María

Publikováno v: European Journal of Nutrition. 52:1649-1659

Arterial hypertension is associated with a high production of reactive oxygen species and a decrease in the antioxidant defense systems. Based on the lack of toxicity of L-carnitine (LC) and previous studies reporting beneficial effects of this compo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2bef0d3d1d052b438f030a3327277d
https://doi.org/10.1007/s00394-012-0470-x

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l-Carnitine ameliorates the oxidative stress response to angiotensin II by modulating NADPH oxidase through a reduction in protein kinase c activity and NF-κB translocation to the nucleus

Autor: Sonia Zambrano, Ana Fortuño, Francisco M. González-Roncero, José L. Miguel-Carrasco, Alfonso Mate, Carmen Vázquez, Elisa Revilla, María V. Ruiz-Armenta, Antonio J. Blanca

Publikováno v: Food chemistry. 228

l-Carnitine (LC) exerts beneficial effects in arterial hypertension due, in part, to its antioxidant capacity. We investigated the signalling pathways involved in the effect of LC on angiotensin II (Ang II)-induced NADPH oxidase activation in NRK-52E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4751a2798525e245c10ee9ce85b25f5e
https://pubmed.ncbi.nlm.nih.gov/28317735

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L-carnitine attenuates the development of kidney fibrosis in hypertensive rats by upregulating PPAR-γ

Autor: José L. Miguel-Carrasco, Miguel Arévalo, Alfonso Mate, Carmen Vázquez, María V. Ruiz-Armenta, Sonia Zambrano, Antonio J. Blanca

Publikováno v: American journal of hypertension. 27(3)

Background The development of renal fibrosis is a consequence of arterial hypertension. L-carnitine plays an essential role in the β-oxidation of fatty acids, and we have previously demonstrated hypotensive, antioxidant, and anti-inflammatory effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8dee49da4fd2cb901ed556eb5e32925
https://pubmed.ncbi.nlm.nih.gov/24413708

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L-Carnitine protects against arterial hypertension-related cardiac fibrosis through modulation of PPAR-γ expression

Autor: Antonio J. Blanca, María V. Ruiz-Armenta, Alfonso Mate, Carmen Vázquez, Sonia Zambrano, María J. Vázquez, José L. Miguel-Carrasco, Miguel Arévalo

Publikováno v: Biochemical pharmacology. 85(7)

Cardiac fibrosis is a pathogenic factor in a variety of cardiovascular diseases and is characterized by an abnormal accumulation of extracellular matrix protein that leads to cardiac dysfunction. l-Carnitine (LC) plays an essential role in the β-oxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3504cb437a3a98ba859718387e5d818
https://pubmed.ncbi.nlm.nih.gov/23295156

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Reduced L-Carnitine Transport in Aortic Endothelial Cells from Spontaneously Hypertensive Rats

Autor: Luis Sobrevia, Carmen Vázquez, Fabián Pardo, María V. Ruiz-Armenta, Sonia Zambrano, Andrea Leiva, Carlos Salomon, Enrique Guzmán-Gutiérrez, Alfonso Mate, Pablo Arroyo, Rocío Salsoso, Antonio J. Blanca

Publikováno v: idUS. Depósito de Investigación de la Universidad de Sevilla
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PLoS ONE, Vol 9, Iss 2, p e90339 (2014)
PLoS ONE
PLOS ONE
Artículos CONICYT
CONICYT Chile
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Impaired L-carnitine uptake correlates with higher blood pressure in adult men, and L-carnitine restores endothelial function in aortic rings from spontaneously hypertensive rat (SHR). Thus, endothelial dysfunction in hypertension could result from l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa65904cfdc842256c290de1fed896b
https://doi.org/10.1371/journal.pone.0090339

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