Data from ERK1/2 Signaling Induces Upregulation of ANGPT2 and CXCR4 to Mediate Liver Metastasis in Colon Cancer

Autor: Roger R. Gomis, Angel R. Nebreda, Eduard Batlle, Cristina Figueras-Puig, Mireia Cartanà, Maria Clapés, Ivan Burkov, Esther Fernandez, Adrià Cañellas, Marc Guiu, Antoni Berenguer-Llergo, Anna Bellmunt, Alicia Llorente, María Teresa Blasco, Jelena Urosevic

Carcinoma development in colorectal cancer is driven by genetic alterations in numerous signaling pathways. Alterations in the RAS-ERK1/2 pathway are associated with the shortest overall survival for patients after diagnosis of colorectal cancer meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2c2ce4811e29dc58a2d796b0829bd2b
https://doi.org/10.1158/0008-5472.c.6512596.v1

Supplementary Figures and Tables from ERK1/2 Signaling Induces Upregulation of ANGPT2 and CXCR4 to Mediate Liver Metastasis in Colon Cancer

Autor: Roger R. Gomis, Angel R. Nebreda, Eduard Batlle, Cristina Figueras-Puig, Mireia Cartanà, Maria Clapés, Ivan Burkov, Esther Fernandez, Adrià Cañellas, Marc Guiu, Antoni Berenguer-Llergo, Anna Bellmunt, Alicia Llorente, María Teresa Blasco, Jelena Urosevic

SF1: The expression of ANGPT2 and CXCR4 in CRC; SF2: Expression levels of ANGPT2, CXCR4, CXCL12, TEK and VEGFA in SW620_P and SW620_LiM2 cells; SF3: Expression levels of ANGPT2 and CXCR4 upon downregulation and upregulation.; SF4: CXCL1 and IL10 expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f78226b7e0fbb2572dabcd993be89e2
https://doi.org/10.1158/0008-5472.22427224.v1

PD-L1 controls cancer pyroptosis

Autor: María Teresa Blasco, Roger R. Gomis

Publikováno v: Nature Cell Biology. 22:1157-1159

Programmed death ligand-1 (PD-L1) is well known for its role as an immune checkpoint regulator, but little is known about its function in other cellular processes. A study now shows that in tumour cells PD-L1 mediates pyroptosis, an inflammatory form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce896b7179214a70fd217e3bed37fc82
https://doi.org/10.1038/s41556-020-00582-w

Impact of donor-recipient age on cardiac transplant survival. Subanalysis of the Spanish Heart Transplant Registry

Autor: José María Arizón del Prado, Juan Delgado-Jiménez, José Manuel Sobrino Márquez, Félix Pérez-Villa, Gregorio Rábago-Aracil, José González-Costello, Luis Almenar-Bonet, Manuel Martínez-Sellés, Raquel López-Vilella, María G. Crespo-Leiro, Luis de la Fuente-Galán, José Luis Lambert-Rodríguez, María Teresa Blasco-Peiró, Déborah Otero, Iris P. Garrido-Bravo, Manuel Cobo, Sonia Mirabet-Pérez, Francisco González-Vílchez, Javier Segovia-Cubero

Publikováno v: Revista espanola de cardiologia (English ed.)
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
REVISTA ESPANOLA DE CARDIOLOGIA
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
RUC. Repositorio da Universidade da Coruña
RUC: Repositorio da Universidade da Coruña
Universidade da Coruña (UDC)

[Abstract] Introduction and objectives. The age of heart transplant recipients and donors is progressively increasing. It is likely that not all donor-recipient age combinations have the same impact on mortality. The objective of this work was to com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a2616079e0f4ee7cd91a558b3773e78
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=13278

H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences

Autor: Isabel Hernández-Porras, Harrys K.C. Jacob, Matthias Drosten, Xosé R. Bustelo, Carmen G. Lechuga, Carmen Guerra, Salvatore Fabbiano, Nicoletta Potenza, Mariano Barbacid, María Teresa Blasco, Lucía Simón-Carrasco

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Genetic studies in mice have provided evidence that H-Ras and K-Ras proteins are bioequivalent. However, human tumors display marked differences in the association of RAS oncogenes with tumor type. Thus, to further assess the bioequivalence of oncoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbb8967ecc1bbdfff4c62c34180598b
https://doi.org/10.1158/0008-5472.can-16-2925