AAV delivery of shRNA against IRS1 in GABAergic neurons in rat hippocampus impairs spatial memory in females and male rats

Autor: Ana María Sánchez-Pérez, Sandra Sánchez-Sarasúa, Alberto Ribes-Navarro, María Teresa Beltrán-Bretones

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Repositori Universitat Jaume I
Universitat Jaume I

Brain insulin resistance is a major factor leading to impaired cognitive function and it is considered as the onset of Alzheimer´s disease. Insulin resistance is intimately linked to inflammatory conditions, many studies have revealed how pro-inflam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0b21e90c892e7eb330f249135a5980
http://hdl.handle.net/10261/248442

Abscisic Acid Supplementation Rescues High Fat Diet-Induced Alterations in Hippocampal Inflammation and IRSs Expression

Autor: Alberto Ribes-Navarro, Mariam Atef, Francisco E. Olucha-Bordonau, Ana María Sánchez-Pérez, María Teresa Beltrán-Bretones, Sandra Sánchez-Sarasúa

Publikováno v: Repositori Universitat Jaume I
Universitat Jaume I

Accumulated evidence indicates that neuroinflammation induces insulin resistance in the brain. Moreover, both processes are intimately linked to neurodegenerative disorders, including Alzheimer's disease. Potential mechanisms underlying insulin resis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35337784808fd6bf3ec3de467a363158
http://hdl.handle.net/10234/175242