Zobrazeno 1 - 10
of 24
pro vyhledávání: '"María T. Dours-Zimmermann"'
Autor:
Sumeda Nandadasa, Cyril Burin des Roziers, Christopher Koch, Karin Tran-Lundmark, María T. Dours-Zimmermann, Dieter R. Zimmermann, Sophie Valleix, Suneel S. Apte
Publikováno v:
Matrix Biology Plus, Vol 10, Iss , Pp 100064- (2021)
Two inherent challenges in the mechanistic interpretation of protease-deficient phenotypes are defining the specific substrate cleavages whose reduction generates the phenotypes and determining whether the phenotypes result from loss of substrate fun
Externí odkaz:
https://doaj.org/article/05b26508a52446369487b95a2ee971df
Autor:
Cyril Burin des Roziers, Sophie Valleix, Dieter R. Zimmermann, Sumeda Nandadasa, Christopher D. Koch, María T. Dours-Zimmermann, Karin Tran-Lundmark, Suneel S. Apte
Publikováno v:
Matrix Biology Plus, Vol 10, Iss, Pp 100064-(2021)
Matrix Biology Plus
Matrix Biology Plus
Highlights • • A novel Vcan mouse allele, VcanAA, has ADAMTS protease-resistant versican. • • VcanAA/AA mice are viable and develop soft tissue-syndactyly (STS) • • VcanAA/AA STS is rendered more severe in combination with Adamts20Bt/Bt.
Autor:
Suneel S. Apte, Courtney M. Nelson, María T. Dours-Zimmermann, J. Larkin, Maritza V. Quintero, Simon J. Foulcer, Dieter R. Zimmermann, Balagurunathan Kuberan
Publikováno v:
Journal of Biological Chemistry. 289:27859-27873
Proteolysis of the Glu(441)-Ala(442) bond in the glycosaminoglycan (GAG) β domain of the versican-V1 variant by a disintegrin-like and metalloproteinase domain with thrombospondin type 1 motif (ADAMTS) proteases is required for proper embryo morphog
Autor:
Dieter R. Zimmermann, Stephan Sickinger, Sarah C. Borrie, María T. Dours-Zimmermann, Antje Kurz, Christine E. Bandtlow, Bastian E. Bäumer
Publikováno v:
The Journal of Neuroscience. 34:1633-1646
Primary sensory afferents of the dorsal root ganglion (DRG) that innervate the skin detect a wide range of stimuli, such as touch, temperature, pain, and itch. Different functional classes of nociceptors project their axons to distinct target zones w
Autor:
Klaus Rüther, María T. Dours-Zimmermann, Barbara Kloeckener-Gruissem, Wolfgang Berger, Sergej Skosyrski, Dieter R. Zimmermann, Corey H. Mjaatvedt, Sandra Brunner
Publikováno v:
Matters.
Patients with the very rare eye pathology Wagner disease (OMIM #143200) present with an abnormal (empty) vitreous, retinal detachment and altered electroretinogram (ERG). The disease is progressive and can eventually lead to blindness. No therapy can
Autor:
David A. Carrino, Arnold I. Caplan, Vincent C. Hascall, Aniq B. Darr, J. Michael Sorrell, Anthony Calabro, John D. Sandy, María T. Dours-Zimmermann, Dieter R. Zimmermann
Publikováno v:
Glycobiology. 21:257-268
Previous work has shown that versican, decorin and a catabolic fragment of decorin, termed decorunt, are the most abundant proteoglycans in human skin. Further analysis of versican indicates that four major core protein species are present in human s
Autor:
Kaspar H. Winterhalter, Michael Schmalfeldt, Dieter R. Zimmermann, María T. Dours-Zimmermann, Christine E. Bandtlow
Publikováno v:
Journal of Cell Science. 113:807-816
In this paper, we identify the chondroitin sulfate proteoglycan versican V2 as a major inhibitor of axonal growth in the extracellular matrix of the mature central nervous system. In immunohistochemical and in situ hybridization experiments we show t
Publikováno v:
Journal of Neuropathology and Experimental Neurology. 55:528-533
Versican is a member of the family of large aggregating chondroitin sulfate proteoglycans which are one of the major constituents of brain extracellular matrix (ECM). We examined the expression of versican splice variants at mRNA and protein levels i
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 836
The complete knockout of genes that give rise to alternative splice products can often provide only an integral view of the dominant function(s) of all the isoforms they encode. If one of these isoforms is indispensable for life, a constitutive and c
Publikováno v:
Journal of Biological Chemistry. 269:32992-32998
We have cloned an alternatively spliced glycosaminoglycan attachment domain (GAG-alpha) of human versican from cDNA libraries derived from U251MG glioma cells. Inserted carboxyl-terminal of the hyaluronan-binding region, this domain adds another 987