Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction model.

Autor: Melania Kurdián, Inmaculada Herrero-Fresneda, Nuria Lloberas, Pepita Gimenez-Bonafe, Virginia Coria, María T Grande, José Boggia, Leonel Malacrida, Joan Torras, Miguel A Arévalo, Francisco González-Martínez, José M López-Novoa, Josep Grinyó, Oscar Noboa

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e32516 (2012)

BackgroundThe immunosuppressive mammalian target of rapamycin (mTOR) inhibitors are widely used in solid organ transplantation, but their effect on kidney disease progression is controversial. mTOR has emerged as one of the main pathways regulating c

Externí odkaz: https://doaj.org/article/af232cd236874a11ba395d91515663ac

Anti-inflammatory agents for smoking cessation? Focus on cognitive deficits associated with nicotine withdrawal in male mice

Autor: Fernando Berrendero, Rafael Maldonado, María T. Grande, Marc Ten-Blanco, Rocio Saravia

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
DDFV: Repositorio Institucional de la Universidad Francisco de Vitoria
Universidad Francisco de Vitoria
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria

Nicotine withdrawal is associated with cognitive deficits including attention, working memory, and episodic memory impairments. These cognitive deficits are a hallmark of nicotine abstinence which could be targeted in order to prevent smoking relapse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcace9684e0afcf2d47b63f0b41f7f75
https://doi.org/10.1016/j.bbi.2018.11.003

Effect of Angiotensin II and Small GTPase Ras Signaling Pathway Inhibition on Early Renal Changes in a Murine Model of Obstructive Nephropathy

Autor: María T. Grande, Isabel Fuentes-Calvo, José M. López-Novoa, Ana B. Rodríguez-Peña, Fernando Pérez-Barriocanal, Neil G. Docherty, Nélida Eleno, Miguel Arévalo

Publikováno v: BioMed Research International
DDFV: Repositorio Institucional de la Universidad Francisco de Vitoria
Universidad Francisco de Vitoria
BioMed Research International, Vol 2014 (2014)
GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
Digital.CSIC. Repositorio Institucional del CSIC

This is an open access article distributed under the Creative Commons Attribution License.
Tubulointerstitial fibrosis is a major feature of chronic kidney disease. Unilateral ureteral obstruction (UUO) in rodents leads to the development of ren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce85cc8b164ae0783536d7f335f8e6ec
http://europepmc.org/articles/PMC4101960

Role of inflammation in túbulo-interstitial damage associated to obstructive nephropathy

Autor: María T. Grande, Fernando Pérez-Barriocanal, José M. López-Novoa

Publikováno v: Journal of Inflammation, Vol 7, Iss 1, p 19 (2010)
Journal of Inflammation (London, England)

Obstructive nephropathy is characterized by an inflammatory state in the kidney, that is promoted by cytokines and growth factors produced by damaged tubular cells, infiltrated macrophages and accumulated myofibroblasts. This inflammatory state contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316ec0500b441196c2ec4d0a24e21962
http://www.journal-inflammation.com/content/7/1/19

Fibroblast activation and myofibroblast generation in obstructive nephropathy

Autor: José M. López-Novoa, María T. Grande

Publikováno v: Nature reviews. Nephrology. 5(6)

Obstructive nephropathy is a major cause of renal failure, particularly in newborn babies and children. After urinary tract obstruction, and under the influence of mechanical forces and cytokines produced by tubular cells and cells that have infiltra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ca03d784619fa5b8d6c5a939aa6479
https://pubmed.ncbi.nlm.nih.gov/19474827