Zobrazeno 1 - 10 of 11 pro vyhledávání: '"María Salomé Gachet"'
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Akademický článek
Elevated Levels of Endocannabinoids in Chronic Hepatitis C May Modulate Cellular Immune Response and Hepatic Stellate Cell Activation
Autor: Eleonora Patsenker, Philip Sachse, Andrea Chicca, María Salomé Gachet, Vreni Schneider, Johan Mattsson, Christian Lanz, Mathias Worni, Andrea de Gottardi, Mariam Semmo, Jochen Hampe, Clemens Schafmayer, Rudolf Brenneisen, Jürg Gertsch, Felix Stickel, Nasser Semmo
Publikováno v: International Journal of Molecular Sciences, Vol 16, Iss 4, Pp 7057-7076 (2015)
The endocannabinoid (EC) system is implicated in many chronic liver diseases, including hepatitis C viral (HCV) infection. Cannabis consumption is associated with fibrosis progression in patients with chronic hepatitis C (CHC), however, the role of E
Externí odkaz: https://doaj.org/article/ef6088cf5268434d8814fd7d69b3c5d0
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2
Pharmacokinetics and pharmacodynamics of γ-hydroxybutyrate in healthy subjects
Autor: Matthias E. Liechti, Evangelia Liakoni, Boris B. Quednow, Dario Dornbierer, Oliver G. Bosch, Erich Seifritz, Jürg Gertsch, Robin von Rotz, María Salomé Gachet
Publikováno v: British Journal of Clinical Pharmacology. 81:980-988
AIMS γ-Hydroxybutyrate (GHB) is used as a treatment for narcolepsy and alcohol withdrawal and as recreational substance. Nevertheless, there are limited data on the pharmacokinetics and pharmacokinetic-pharmacodynamic relationship of GHB in humans.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cdc46fa54a01e7dc91387bcc1fe916c
https://doi.org/10.1111/bcp.12863
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3
Elevated Levels of Endocannabinoids in Chronic Hepatitis C May Modulate Cellular Immune Response and Hepatic Stellate Cell Activation
Autor: Johan Mattsson, Felix Stickel, Jochen Hampe, Eleonora Patsenker, Rudolf Brenneisen, Christian Lanz, Mathias Worni, Mariam Semmo, Philip Sachse, Vreni Schneider, Nasser Semmo, Andrea Chicca, Jürg Gertsch, María Salomé Gachet, Andrea De Gottardi, Clemens Schafmayer
Publikováno v: International Journal of Molecular Sciences
Volume 16
Issue 4
Pages 7057-7076
Patsenker, Eleanora; Sachse, Philip; Chicca, Andrea; Gachet Otanez, Maria Salomé; Schneider, Vreni; Mattsson, Johan; Lanz, Christian; Worni, Mathias; De Gottardi, Andrea; Semmo, Mariam; Hampe, Jochen; Schafmayer, Clemens; Brenneisen, Rudolf Max; Gertsch, Jürg; Stickel, Felix; Semmo, Nasser (2015). Elevated levels of endocannabinoids in chronic hepatitis C may modulate cellular immune response and hepatic stellate cell activation. International journal of molecular sciences, 16(4), pp. 7057-7076. Molecular Diversity Preservation International MDPI 10.3390/ijms16047057
International Journal of Molecular Sciences, Vol 16, Iss 4, Pp 7057-7076 (2015)
The endocannabinoid (EC) system is implicated in many chronic liver diseases, including hepatitis C viral (HCV) infection. Cannabis consumption is associated with fibrosis progression in patients with chronic hepatitis C (CHC), however, the role of E
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281c41b44b21caddf7f3e2618c0a9b06
https://doi.org/10.3390/ijms16047057
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4
Targeted metabolomics shows plasticity in the evolution of signaling lipids and uncovers old and new endocannabinoids in the plant kingdom
Autor: Serafina Calarco, Jürg Gertsch, María Salomé Gachet, Julien Boccard, Alexandra Schubert
Publikováno v: Gachet Otanez, Maria Salomé; Schubert, Alexandra; Calarco, Serafina; Boccard, Julien; Gertsch, Jürg (2017). Targeted metabolomics shows plasticity in the evolution of signaling lipids and uncovers old and new endocannabinoids in the plant kingdom. Scientific Reports, 7, p. 41177. Nature Publishing Group 10.1038/srep41177
Scientific Reports
The remarkable absence of arachidonic acid (AA) in seed plants prompted us to systematically study the presence of C20 polyunsaturated fatty acids, stearic acid, oleic acid, jasmonic acid (JA), N-acylethanolamines (NAEs) and endocannabinoids (ECs) in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89b34b0fbdc0545f7cc404558d0b6ad
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5
A quantitiative LC-MS/MS method for the measurement of arachidonic acid, prostanoids, endocannabinoids, N-acylethanolamines and steroids in human plasma
Autor: María Salomé Gachet, Oliver G. Bosch, Boris B. Quednow, Peter Rhyn, Jürg Gertsch
Publikováno v: J Chromatogr B Analyt Technol Biomed Life Sci.
Free arachidonic acid is functionally interlinked with different lipid signaling networks including those involving prostanoid pathways, the endocannabinoid system, N-acylethanolamines, as well as steroids. A sensitive and specific LC-MS/MS method fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370efc13809cb1627c9ae47fe8621ef6
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6
4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation
Autor: Vanessa Petrucci, María Salomé Gachet, Andrea Chicca, Jürg Gertsch, Wolfgang Schuehly, Roch-Philippe Charles
Publikováno v: Journal of Neuroinflammation
Chicca, Andrea; Gachet Otanez, Maria Salomé; Petrucci, Vanessa; Schuehly, Wolfgang; Charles, Roch-Philippe; Gertsch, Jürg (2015). 4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation. Journal of neuroinflammation, 12, p. 89. BioMed Central 10.1186/s12974-015-0307-7
Background and purpose 4′-O-methylhonokiol (MH) is a natural product showing anti-inflammatory, anti-osteoclastogenic, and neuroprotective effects. MH was reported to modulate cannabinoid CB2 receptors as an inverse agonist for cAMP production and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b8682699a1609a96980b79f1e1f704
https://pubmed.ncbi.nlm.nih.gov/25962384
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7
Variation of the Detergent-Binding Capacity and Phospholipid Content of Membrane Proteins When Purified in Different Detergents
Autor: Dimitrios Fotiadis, Hüseyin Ilgü, Jean-Marc Jeckelmann, María Salomé Gachet, Rajendra Boggavarapu, Zöhre Ucurum, Jürg Gertsch
Publikováno v: Ilgü, Hüseyin; Jeckelmann, Jean-Marc; Gachet Otanez, Maria Salomé; Boggavarapu, Venkata Ravi Naga Rajendr; Ucurum Fotiadis, Zöhre; Gertsch, Jürg; Fotiadis, Dimitrios José (2014). Variation of the detergent-binding capacity and phospholipid content of membrane proteins when purified in different detergents. Biophysical journal, 106(8), pp. 1660-1670. Biophysical Society 10.1016/j.bpj.2014.02.024
Purified membrane proteins are ternary complexes consisting of protein, lipid, and detergent. Information about the amounts of detergent and endogenous phospholipid molecules bound to purified membrane proteins is largely lacking. In this systematic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91fee5e9ccfec2a21c3c52b88124478f
https://europepmc.org/articles/PMC4008799/
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8
Guineensine is a novel inhibitor of endocannabinoid uptake showing cannabimimetic behavioral effects in BALB/c mice
Autor: J Gertsch, Juan Manuel Viveros-Paredes, Martina Blunder, M.E. Flores-Soto, Mark Rau, Simon Nicolussi, María Salomé Gachet
Publikováno v: Pharmacological research. 80
High-content screening led to the identification of the N -isobutylamide guineensine from Piper nigrum as novel nanomolar inhibitor (EC 50 = 290 nM) of cellular uptake of the endocannabinoid anandamide (AEA). Noteworthy, guineensine did not inhibit e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be534d7843876680b7c7e469450f8167
https://pubmed.ncbi.nlm.nih.gov/24412246
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9
Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense
Autor: Martin Zehl, W. Keller, María Salomé Gachet, Wolfgang Schuehly, Marcel Kaiser, Reto Brun, Rudolf Bauer, Ricardo Muñoz, Olaf Kunert
Publikováno v: Journal of natural products. 74(4)
In a survey of plants from Ecuador with antiprotozoal activity, Cupania cinerea was found to show significant in vitro activity against the Plasmodium falciparum K1 strain and Trypanosoma brucei rhodesiense. Subsequently, activity-guided isolation of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1495340bacb9494d11a21fc1ff7ada
https://pubmed.ncbi.nlm.nih.gov/21438586
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10
Assessment of anti-protozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis
Autor: Wolfgang Schühly, Javier Salazar Lecaro, Rudolf Bauer, Hugo Navarrete, María Salomé Gachet, Marcel Kaiser, Ricardo Muñoz, Reto Brun
Publikováno v: Journal of ethnopharmacology. 128(1)
Aim of the Study For the assessment of the in vitro anti-protozoal potential of plants traditionally used in Ecuador in the treatment of leishmaniasis, a combined approach based on interviews with healers as well as a literature search was carried ou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a15b47f88fc6099f938c4b538c5248
https://pubmed.ncbi.nlm.nih.gov/20064594
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