Výsledky vyhledávání - "María S. Domínguez-Sánchez"

Akademický článek

Genome instability and transcription elongation impairment in human cells depleted of THO/TREX.

Autor: María S Domínguez-Sánchez, Sonia Barroso, Belén Gómez-González, Rosa Luna, Andrés Aguilera

Publikováno v: PLoS Genetics, Vol 7, Iss 12, p e1002386 (2011)

THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian THO in these processes is uncertain, which suggests a differential implication of mRNP biogenesis factors in genome integrity in yeast and humans. We show that hu

Externí odkaz: https://doaj.org/article/89827ce515b94bea8bfcd6281c483cd5

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Methylation of the central transcriptional regulator KLF4 by PRMT5 is required for DNA end resection and recombination

Autor: Javier Ramón, Daniel Gómez-Cabello, Cristina Cepeda-García, María S. Domínguez-Sánchez, Cintia Checa-Rodríguez, Ana López-Saavedra, Fernando R. Balestra, Pablo Huertas

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Cell fitness and survival upon exposure to DNA damage depends on the repair of DNA lesions. Interestingly, cellular identity does affect and finetunes such response, although the molecular basis of such differences between tissues and cell types is n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546c3b380d24bc7b21a9be2841b61e38
http://hdl.handle.net/10261/221253

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A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection

Autor: Fernando Mejías-Navarro, María Isabel Martínez-Macías, Pablo Huertas, Daniel Gómez-Cabello, Ana López-Saavedra, María S. Domínguez-Sánchez, Jiri Bartek, María Jesús Fernández-Ávila, Christoffel Dinant

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

There are two major and alternative pathways to repair DNA double-strand breaks: non-homologous end-joining and homologous recombination. Here we identify and characterize novel factors involved in choosing between these pathways; in this study we to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edbb6b0be1cb66fa03b6808ef58eaac4

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Cytoplasmic interaction of the tumour suppressor protein hSNF5 with dynamin-2 controls endocytosis

Autor: Mario García-Domínguez, José C. Reyes, Tatiana Alfonso-Pérez, María S. Domínguez-Sánchez

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Human SNF5 (hSNF5; INI1, SMARCB1 or BAF47) is a component of the human SWI/SNF chromatin remodelling complex and a tumour suppressor mutated in rhabdoid tumours. It also associates with the integrase of the human immunodeficiency virus (HIV)-1. We sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575e073675dd5ea5a310c1622f3727cf
http://hdl.handle.net/10261/123202

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Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX

Autor: Rosa Luna, Sonia Barroso, María S. Domínguez-Sánchez, Belén Gómez-González, Andrés Aguilera

Publikováno v: idUS. Depósito de Investigación de la Universidad de Sevilla
instname
PLoS Genetics, Vol 7, Iss 12, p e1002386 (2011)
Digital.CSIC. Repositorio Institucional del CSIC
PLoS Genetics

This is an open-access article distributed under the terms of the Creative Commons Attribution License.
THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian THO in these processes is uncertain, which suggests a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55734b34817f9ada440bb8425759a066
https://idus.us.es/handle/11441/55832

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Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers

Autor: Miguel A. Japón, Carmen Sáez, Rosa Luna, Andrés Aguilera, María S. Domínguez-Sánchez

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Scopus-Elsevier
BMC Cancer, Vol 11, Iss 1, p 77 (2011)
BMC Cancer
idUS. Depósito de Investigación de la Universidad de Sevilla

[Background]: One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts physically and func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2713ef3e9c70328e1f3bd55003fe83
http://hdl.handle.net/10261/48949

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