Výsledky vyhledávání - "María Sánchez-Flores"

Akademický článek

Low Vitamin D Levels and Frailty Status in Older Adults: A Systematic Review and Meta-Analysis

Autor: Diego Marcos-Pérez, María Sánchez-Flores, Stefania Proietti, Stefano Bonassi, Solange Costa, Joao Paulo Teixeira, Juan Fernández-Tajes, Eduardo Pásaro, Vanessa Valdiglesias, Blanca Laffon

Publikováno v: Nutrients, Vol 12, Iss 8, p 2286 (2020)

Serum vitamin D deficiency is widespread among older adults and is a potential modifiable risk factor for frailty. Moreover, frailty has been suggested as an intermediate step in the association between low levels of vitamin D and mortality. Hence, w

Externí odkaz: https://doaj.org/article/9c6fbdb58ed9484c91c2be66c92299b5

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Akademický článek

Frailty in Older Adults Is Associated With Plasma Concentrations of Inflammatory Mediators but Not With Lymphocyte Subpopulations

Autor: Diego Marcos-Pérez, María Sánchez-Flores, Ana Maseda, Laura Lorenzo-López, José C. Millán-Calenti, Johanna M. Gostner, Dietmar Fuchs, Eduardo Pásaro, Blanca Laffon, Vanessa Valdiglesias

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Frailty denotes a multidimensional syndrome that gives rise to vulnerability to stressors and leads to an increase of the age-related decline of different physiological systems and cognitive abilities. Aging-related alterations of the immune system m

Externí odkaz: https://doaj.org/article/18e744417b6b4c4e9aaffc50fdc32e2a

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Expanded usage of the Challenge-Comet assay as a DNA repair biomarker in human populations: protocols for fresh and cryopreserved blood samples, and for different challenge agents

Autor: Blanca Laffon, William W. Au, Vanessa Valdiglesias, Eduardo Pásaro, María Sánchez-Flores, Natalia Fernández-Bertólez

Publikováno v: Archives of Toxicology. 94:4219-4228

Deficiencies in DNA damage response and repair (DDRR) can cause serious pathological outcomes; therefore, having an ability to determine individual DDRR would enhance specificities in health risk assessment and in determining individual's response to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3343c0f6fd61773b9ac80cccaac8b924
https://doi.org/10.1007/s00204-020-02881-5

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Elevated serum neopterin concentration increases mortality risk in patients with acute pancreatitis

Autor: Blanca Laffon, Laura Lorenzo-López, Eduardo Pásaro, Johanna M. Gostner, Diego Marcos-Pérez, Vanessa Valdiglesias, Ana Maseda, María Sánchez-Flores, Dietmar Fuchs, José Carlos Millán-Calenti

Publikováno v: Pteridines, Vol 30, Iss 1, Pp 16-20 (2019)

Background The aim of this study was to investigate serum neopterin levels in patients with acute pancreatitis (AP) and its predictive value for mortality in cases of severe acute pancreatitis (SAP). Methods Eighty-two patients with confirmed acute p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6e4f0685dde1488804611c06683770
https://doaj.org/article/4f1dbf7083de46f3bc6376c81c31f57d

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Applicability of flow cytometry γH2AX assay in population studies: suitability of fresh and frozen whole blood samples

Autor: María Sánchez-Flores, Blanca Laffon, Eduardo Pásaro, Vanessa Valdiglesias, Natalia Fernández-Bertólez

Publikováno v: Archives of toxicology. 95(5)

Phosphorylation of H2AX histone (γH2AX) represents an early event in the DNA damage response against double-strand breaks (DSB); hence, its measurement provides a surrogate biomarker of DSB. Recently, we reported initial steps in the standardization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfefd6b4f0ab90fcc04581d4c1af3cda
https://pubmed.ncbi.nlm.nih.gov/33624155

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Association of inflammatory mediators with frailty status in older adults: results from a systematic review and meta-analysis

Autor: Stefano Bonassi, Eduardo Pásaro, Juan Fernández-Tajes, João Paulo Teixeira, Vanessa Valdiglesias, María Sánchez-Flores, Blanca Laffon, Stefania Proietti, Diego Marcos-Pérez, Solange Costa

Publikováno v: GeroScience

Frailty is a geriatric syndrome defined as a status of extreme vulnerability to stressors, leading to a higher risk of negative health-related outcomes. "Inflammaging", an age-related state of low-grade chronic inflammation, is characterized by an in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0543612ad342511f81236595e23bc25
https://europepmc.org/articles/PMC7732924/

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Expanded usage of the Challenge-Comet assay as a DNA repair biomarker in human populations: protocols for fresh and cryopreserved blood samples, and for different challenge agents

Autor: Vanessa, Valdiglesias, María, Sánchez-Flores, Natalia, Fernández-Bertólez, William, Au, Eduardo, Pásaro, Blanca, Laffon

Publikováno v: Archives of toxicology. 94(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59ac335dd931fe5b0950c7c3844546c1
https://pubmed.ncbi.nlm.nih.gov/33000292

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The impact of comet assay data normalization in human biomonitoring studies outcomes

Autor: María Sánchez-Flores, João Paulo Teixeira, Susana Silva, Raquel Amaro, Carla Costa, Filipa Esteves

The comet assay has been extensively used in biomonitoring studies. To avoid intra-experimental variability, the incorporation of assay controls in each work session for data normalization has been suggested by some authors but has never been thoroug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41328e771313753fdeb1f0a6877ebfd8
https://hdl.handle.net/10216/143350

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Oxidative stress, genomic features and DNA repair in frail elderly: A systematic review

Autor: María Sánchez-Flores, Blanca Laffon, Solange Costa, João Paulo Teixeira, Diego Marcos-Pérez, Vanessa Valdiglesias, Eduardo Pásaro, Stefano Bonassi

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Frailty is an emerging geriatric syndrome characterized by higher vulnerability to stressors, with an increased risk of adverse health outcomes such as mortality, morbidity, disability, hospitalization, and institutionalization. Although it is genera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0468e51eef11a5a24a579348830742
https://doi.org/10.1016/j.arr.2017.05.001

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Serum cortisol but not oxidative stress biomarkers are related to frailty: results of a cross-sectional study in Spanish older adults

Autor: Vanessa Valdiglesias, Blanca Laffon, Diego Marcos-Pérez, José Carlos Millán-Calenti, Laura Lorenzo-López, Eduardo Pásaro, María Sánchez-Flores, Ana Maseda

Publikováno v: RUC: Repositorio da Universidade da Coruña
Universidade da Coruña (UDC)
RUC. Repositorio da Universidade da Coruña
Universitat Oberta de Catalunya (UOC)

[Abstract] Frailty is a multidimensional geriatric syndrome of loss of reserves and increased vulnerability to negative health outcomes. Cortisol, the major hormone of the hypothalamic pituitary adrenal (HPA) axis, and oxidative stress may be influen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd441cb85ffc682fd941f11f073444e4
http://hdl.handle.net/2183/26182

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